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Rotigotine transdermal patch for the treatment of neuropsychiatric symptoms in Parkinson's disease: A meta-analysis of randomized placebo-controlled trials.

Author: HeYi, WangHao-Tian, WangLi, YuGang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Rotigotine transdermal patch effectively improved neuropsychiatric symptoms and quality of life in patients with Parkinson's disease (PD). Significant improvements were observed in scores for the emotion/apathy, sleep/fatigue, and quality of life domains.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To systematically evaluate and quantify the effects of rotigotine treatment on neuropsychiatric symptoms in Parkinson's disease (PD). METHODS: We searched for articles involving randomized controlled trials (RCTs) that were published before September 1, 2017, in the PubMed, Clinical Tria...See full text at original site
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引用元：
https://doi.org/10.1016/j.jns.2018.08.003

データ提供：米国国立医学図書館（NLM）

Rotigotine: A Potential Treatment for Neuropsychiatric Symptoms in Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disorder that can affect various aspects of a person's life, including their mental health. This meta-analysis investigates the efficacy of rotigotine, a dopamine agonist, in treating neuropsychiatric symptoms in PD. The researchers analyzed data from eight randomized controlled trials (RCTs), examining the effects of rotigotine on mood, apathy, sleep, and quality of life in patients with PD. Their findings suggest that rotigotine could be a valuable tool in managing neuropsychiatric symptoms associated with PD.

Rotigotine: A Potential Solution for Neuropsychiatric Symptoms in Parkinson's Disease

The meta-analysis found that rotigotine significantly improved scores on various scales used to assess neuropsychiatric symptoms, including mood, apathy, and sleep disturbances. These findings are encouraging, suggesting that rotigotine could be a valuable treatment option for managing these challenging symptoms in patients with PD. This is akin to a desert traveler who discovers a refreshing oasis, offering respite and renewal from the harsh elements. Just as the oasis provides shelter and sustenance, rotigotine can provide relief from the neuropsychiatric symptoms associated with PD.

Understanding the Complexities of Parkinson's Disease

This meta-analysis underscores the importance of addressing neuropsychiatric symptoms in patients with PD. While rotigotine shows promise as a treatment option, it's important to recognize that PD is a complex disorder with a wide range of symptoms. Just as a desert traveler must adapt their journey based on the changing landscape, healthcare providers must tailor treatment plans to the individual patient's needs, considering the unique challenges posed by each case of PD.

Dr.Camel's Conclusion

This meta-analysis provides compelling evidence for the efficacy of rotigotine in treating neuropsychiatric symptoms in Parkinson's disease. While further research is needed to fully understand its long-term effects and optimal dosage, the findings offer a glimmer of hope for patients seeking relief from these debilitating symptoms.

Date :
  1. Date Completed 2019-07-23
  2. Date Revised 2019-07-23
Further Info :

Pubmed ID

30099246

DOI: Digital Object Identifier

10.1016/j.jns.2018.08.003

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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