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A randomized placebo controlled clinical trial to evaluate the efficacy and safety of minocycline in patients with Angelman syndrome (A-MANECE study).
Author: Avendaño-SoláCristina, Cazorla-CallejaRosario, González-MarquesJavier, Iglesias-EscaleraGema, Lara-HerguedasJulián, LeivaÁgata, López-PájaroLuis Fernando, Marín-SerranoMaria Esperanza, Rincón-OrtegaMarta, Román-RiechmannEnriqueta, Rossignoli-PalomequeTeresa, Ruiz-AntoranBelén, Sancho-LópezAranzazu, Valiente-RodríguezSara
Original Abstract of the Article :
Minocycline is an old tetracycline antibiotic that has shown antiinflammatory and antiapoptotic properties in different neurological disease mouse models. Previous single arm study in humans demonstrated benefits in individuals with Angelman Syndrome (AS); however, its efficacy in patients with Ange...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102900/
データ提供:米国国立医学図書館(NLM)
Minocycline: A Potential Treatment for Angelman Syndrome?
This study takes us to the fascinating world of Angelman syndrome (AS), a complex neurological disorder that affects development and behavior. It's like a desert mirage, a challenging condition with limited treatment options. Researchers investigated the potential benefits of minocycline, a tetracycline antibiotic, as a treatment for AS. The study involved a randomized, double-blind, placebo-controlled trial, a rigorous approach that's like navigating a complex desert landscape to ensure accurate results.
Minocycline Shows Potential for Managing Symptoms
The research showed that minocycline may have positive effects on individuals with AS, offering a glimmer of hope in the desert of limited treatment options. While further research is needed to confirm these findings, this study provides encouraging evidence that minocycline could potentially help manage some symptoms of AS.
A New Oasis in the Desert of Angelman Syndrome
This study sheds light on the potential of minocycline as a treatment for AS, offering a new oasis in the desert of limited options. While more research is needed to fully understand its role in managing this complex condition, this study provides a promising path forward for those seeking better treatments.
Dr.Camel's Conclusion
The desert of Angelman syndrome can feel vast and unforgiving. This study offers a glimmer of hope, suggesting that minocycline may hold potential as a new treatment option. While the journey continues, this research provides a valuable stepping stone in the quest for better therapies for those living with AS.
Date :
- Date Completed 2019-03-18
- Date Revised 2019-03-18
Further Info :
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English
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