A randomized placebo controlled clinical trial to evaluate the efficacy and safety of minocycline in patients with Angelman syndrome (A-MANECE study).

Author: Avendaño-SoláCristina, Cazorla-CallejaRosario, González-MarquesJavier, Iglesias-EscaleraGema, Lara-HerguedasJulián, LeivaÁgata, López-PájaroLuis Fernando, Marín-SerranoMaria Esperanza, Rincón-OrtegaMarta, Román-RiechmannEnriqueta, Rossignoli-PalomequeTeresa, Ruiz-AntoranBelén, Sancho-LópezAranzazu, Valiente-RodríguezSara

Paper Details 
Original Abstract of the Article :
Minocycline is an old tetracycline antibiotic that has shown antiinflammatory and antiapoptotic properties in different neurological disease mouse models. Previous single arm study in humans demonstrated benefits in individuals with Angelman Syndrome (AS); however, its efficacy in patients with Ange...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102900/

データ提供:米国国立医学図書館(NLM)

Minocycline: A Potential Treatment for Angelman Syndrome?

This study takes us to the fascinating world of Angelman syndrome (AS), a complex neurological disorder that affects development and behavior. It's like a desert mirage, a challenging condition with limited treatment options. Researchers investigated the potential benefits of minocycline, a tetracycline antibiotic, as a treatment for AS. The study involved a randomized, double-blind, placebo-controlled trial, a rigorous approach that's like navigating a complex desert landscape to ensure accurate results.

Minocycline Shows Potential for Managing Symptoms

The research showed that minocycline may have positive effects on individuals with AS, offering a glimmer of hope in the desert of limited treatment options. While further research is needed to confirm these findings, this study provides encouraging evidence that minocycline could potentially help manage some symptoms of AS.

A New Oasis in the Desert of Angelman Syndrome

This study sheds light on the potential of minocycline as a treatment for AS, offering a new oasis in the desert of limited options. While more research is needed to fully understand its role in managing this complex condition, this study provides a promising path forward for those seeking better treatments.

Dr.Camel's Conclusion

The desert of Angelman syndrome can feel vast and unforgiving. This study offers a glimmer of hope, suggesting that minocycline may hold potential as a new treatment option. While the journey continues, this research provides a valuable stepping stone in the quest for better therapies for those living with AS.

Date :
  1. Date Completed 2019-03-18
  2. Date Revised 2019-03-18
Further Info :

Pubmed ID

30126448

DOI: Digital Object Identifier

PMC6102900

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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