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Macular Morphology and Visual Acuity in Year Five of the Comparison of Age-related Macular Degeneration Treatments Trials.

Author: , DanielEbenezer, GrunwaldJuan E, JaffeGlenn J, MaguireMaureen G, MartinDaniel F, TothCynthia A, YingGui-Shuang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Subretinal hyper-reflective material (SHRM), thinner retina, greater choroidal neovascularization (CNV) lesion area, foveal center pathology, and intraretinal fluid (IRF) were independently associated with worse visual acuity (VA) in patients with age-related macular degeneration (AMD). VA was significantly lower in patients with geographic atrophy (GA) and fibrotic scars compared to those without. New foveal scar, CNV, IRF, SHRM, and retinal thinning, development or worsening of foveal GA, and increased lesion size were associated with greater VA loss.
Paper Details　
Original Abstract of the Article :
PURPOSE: To evaluate associations of morphologic features with 5-year visual acuity (VA) in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort study within a randomized clinical trial. PARTICIPANTS: Participants in CATT. METHODS: Eyes with age-related macu...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/30189282

データ提供：米国国立医学図書館（NLM）

Macular Morphology: A Guide Through the Sands of Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, affecting millions worldwide. This study focuses on the relationship between macular morphology and visual acuity in participants enrolled in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). The authors analyzed OCT and fundus photography data to identify specific morphologic features associated with visual acuity at five years.

Macular Morphology: A Road Map for Visual Acuity

The study revealed that several morphologic features were independently associated with worse visual acuity at five years, including the presence of subretinal hyper-reflective material (SHRM), retinal thinning, larger CNV lesion area, and foveal center pathology. These findings provide valuable insights into the progression of AMD and its impact on vision.

Navigating the Sands of Vision Loss: Understanding AMD

This research underscores the importance of understanding the underlying mechanisms of AMD and its impact on visual acuity. By identifying specific morphologic features associated with vision loss, researchers can develop more targeted therapies to address the progression of this debilitating disease.

Dr.Camel's Conclusion

Macular morphology, like a map guiding a camel across the desert, reveals clues to the progression of AMD. This study highlights the importance of understanding these visual markers for developing effective treatments and preserving vision in individuals with AMD.

Date :
  1. Date Completed 2019-12-06
  2. Date Revised 2020-03-09
Further Info :

Pubmed ID

30189282

DOI: Digital Object Identifier

NIHMS1506232

Related Literature

Article Analysis
・Effective treatment of macular degeneration
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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