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CYP3A Activation and Glutathione Depletion Aggravate Emodin-Induced Liver Injury.

Author: FanYa-Xi, JiangLi-Long, JiangYan, LiHui-Jun, LiPing, YuQiong, ZhaoDong-Sheng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Emodin, a natural product found in herbal medicines, can cause liver damage. Studies show that emodin's toxicity is increased when CYP3A is activated and glutathione (GSH) is depleted. This information can help to identify risk factors and understand the mechanism of emodin-induced hepatotoxicity.
Paper Details　
Original Abstract of the Article :
1,3,8-Trihydroxy-6-methylanthraquinone (emodin), a widely existing natural product in herbal medicines, has been reported to be hepatotoxic, but the exact underlying mechanism is still not fully understood. The objective of the present study was to evaluate the role of CYP3A and glutathione (GSH) in...See full text at original site
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引用元：
https://doi.org/10.1021/acs.chemrestox.8b00117

データ提供：米国国立医学図書館（NLM）

Emodin and Liver Toxicity: Uncovering the Mechanism

Emodin, a natural compound found in many herbal medicines, has been associated with hepatotoxicity. This study delves into the mechanisms by which emodin can induce liver injury, specifically focusing on the role of CYP3A and glutathione (GSH). This research is crucial for understanding the potential risks of emodin-containing herbal medicines and for informing safer use of these products.

CYP3A and GSH: Key Players in Emodin Toxicity

The study found that activation of CYP3A and depletion of GSH significantly increased emodin-mediated cytotoxicity in both primary human hepatocytes and rats. These findings suggest that CYP3A induction and GSH depletion may be critical factors in the development of emodin-induced liver injury.

Protecting the Liver: Understanding the Risks of Emodin

The findings highlight the importance of considering the potential hepatotoxicity of emodin, especially when CYP3A is activated or GSH is depleted. This research underscores the need for careful evaluation and management of emodin-containing herbal medicines to minimize the risk of liver injury.

Dr.Camel's Conclusion

Imagine the desert as a vast expanse of potential, with hidden dangers lurking beneath the surface. Just as a camel must be mindful of the treacherous terrain, so too must we be cautious about the potential risks of natural products. This study provides crucial insights into the mechanisms behind emodin-induced liver toxicity, guiding us toward safer and more responsible use of herbal medicines.
Date :
  1. Date Completed 2019-08-06
  2. Date Revised 2019-08-06
Further Info :

Pubmed ID

30203651

DOI: Digital Object Identifier

10.1021/acs.chemrestox.8b00117

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