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Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine's Analgesic Effect on Incisional Pain in Rats.

Author: AdlerMartin W, ChenXiaohong, CowanAlan, DouraMenahem, EisensteinToby K, GellerEllen B, InanSaadet, MeisslerJoseph J, RawlsScott M, TallaridaChristopher S, WatsonMia N

Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigated the effect of coadministration of chemokine receptor antagonists (CRAs) with morphine on incisional pain in rats. The results show that combining morphine with CRAs potentiates its analgesic effect, allowing for the same analgesic effect with lower doses of morphine. This could potentially reduce side effects and prevent tolerance and dependence development.
Paper Details　
Original Abstract of the Article :
Crossdesensitization between opioid and chemokine receptors and involvement of chemokines in pain modulation are well established. We investigated if coadministration of chemokine receptor antagonists (CRAs) with morphine would enhance the analgesic potency of morphine on incisional pain in rats. An...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226546/

データ提供：米国国立医学図書館（NLM）

Chemokine Receptor Antagonists: Enhancing Morphine’s Analgesic Effects

This study examines the synergistic effects of chemokine receptor antagonists (CRAs) in combination with morphine for pain management. The researchers used a [research methodology] to evaluate the analgesic effects of morphine, maraviroc (a CCR5 antagonist), AMD3100 (a CXCR4 antagonist), and their combinations in rats undergoing incisional surgery. The study's findings suggest that coadministering CRAs with morphine significantly potentiates the analgesic effects of morphine, implying a potential strategy for optimizing pain management.

A New Approach to Pain Management

The study's findings suggest a promising approach to managing pain effectively while minimizing the potential side effects associated with morphine. By combining CRAs with morphine, clinicians can achieve the same analgesic effects with lower doses of morphine, potentially reducing the risk of opioid tolerance and dependence. This synergistic approach to pain management could offer a more personalized and effective treatment strategy for patients.

Navigating the Challenges of Pain Management

The desert of pain can be a daunting landscape, often difficult to navigate. This research offers a new oasis of knowledge, highlighting the potential of combining chemokine receptor antagonists with morphine to enhance pain management. This approach could lead to more effective and safer pain management strategies, offering hope for a more comfortable journey through the desert of pain.

Dr.Camel's Conclusion

Just as a caravan relies on the collective strength of its members to traverse the desert, this research reveals the power of combining different medications to achieve optimal results. The synergy between CRAs and morphine holds exciting possibilities for pain management, offering a more effective and potentially safer approach for alleviating suffering and restoring comfort.

Date :
  1. Date Completed 2019-10-04
  2. Date Revised 2019-12-01
Further Info :

Pubmed ID

30249618

DOI: Digital Object Identifier

PMC6226546

Related Literature

Article Analysis
・Side Effects of maraviroc
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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