Paper Details

  1. Home
  2. Paper Details

Predicting the outcome of corticoid therapy for acute ulcerative colitis. Results of a prospective, randomized, double-blind clinical trial.

Author: FeuerE J, JanowitzH D, JohnsonJ W, LererP K, MeyersS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study examined factors predicting the success of corticosteroid treatment for 66 patients with severe ulcerative colitis. 42% of patients achieved remission within 10 days of treatment. Factors associated with successful treatment included less severe disease activity, such as the absence of fulminant colitis, limited disease extent, shorter duration of symptoms, fewer stools, lower erythrocyte sedimentation rate, and higher hemoglobin. Early remission was also associated with a more favorable long-term outcome. Prolonging treatment beyond 10 days did not improve remission rates and may have increased the risk of needing surgery. The study concludes that early remission during the initial 10-day treatment period is the most important factor predicting a positive outcome for patients with severe ulcerative colitis.
Paper Details　
Original Abstract of the Article :
We looked for factors predicting the therapeutic outcome in 66 patients with severe ulcerative colitis treated with intravenous hydrocortisone or corticotropin (ACTH) for 10 days. Patients were randomized before therapy within strata defined by whether they had received oral corticosteroids continuo...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/00004836-198702000-00013

データ提供：米国国立医学図書館（NLM）

Acute Ulcerative Colitis: Predicting the Course of Corticoid Therapy

This study investigates factors predicting the therapeutic outcome in patients with severe ulcerative colitis treated with intravenous hydrocortisone or corticotropin (ACTH). The researchers conducted a prospective, randomized, double-blind clinical trial involving patients with severe ulcerative colitis, aiming to identify predictors of therapeutic success and understand the role of prolonged corticoid therapy in achieving remission.

Ulcerative Colitis: A Tale of Two Treatment Approaches

The study found that patients with less severe colitis activity, as indicated by factors such as limited disease extent, shorter duration of the attack, and fewer stools, were more likely to achieve therapeutic success. Interestingly, patients with more severe colitis, including those with bloody stools and a shorter total disease duration, were more likely to respond early to corticoid therapy if they were ultimately to achieve remission. However, prolonging therapy beyond 10 days did not significantly improve remission rates.

Ulcerative Colitis: A Multifaceted Journey

This study highlights the complex nature of ulcerative colitis and the importance of early intervention to optimize treatment outcomes. The findings suggest that personalized treatment strategies, tailored to the severity of the disease, may be essential for achieving long-term remission. The researchers emphasize the need for further research to identify more effective and targeted therapies for this debilitating condition.

Dr. Camel's Conclusion

This research provides valuable insights into the factors influencing the therapeutic outcome in patients with severe ulcerative colitis. The study underscores the importance of considering individual patient characteristics and disease severity when determining treatment strategies. Furthermore, it emphasizes the need for continued research to develop more effective and targeted therapies for this challenging condition.
Date :
  1. Date Completed 1987-05-21
  2. Date Revised 2019-08-17
Further Info :

Pubmed ID

3031150

DOI: Digital Object Identifier

10.1097/00004836-198702000-00013

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.