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New opioid receptor modulators and agonists.

Author: ColontonioMatthew M, CornettElyse M, GennusoSonja A, KayeAaron J, KayeAlan D, LatimerDustin R, PatilShilpa S, UrmanRichard D, VadiveluNalini

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the development of novel opioid receptor modulators, which aim to provide pain relief with fewer side effects compared to traditional opioids. These modulators can act as both agonists and antagonists, interacting with different opioid receptors. The review highlights the potential of these compounds in treating pain, opioid abuse, and addiction, emphasizing the importance of continued research and development in this field.
Paper Details　
Original Abstract of the Article :
There has been significant research to develop an ideal synthetic opioid. Opioids with variable properties possessing efficacy and with reduced side effects have been synthesized when compared to previously used agents. An opioid modulator is a drug that can produce both agonistic and antagonistic e...See full text at original site
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引用元：
https://doi.org/10.1016/j.bpa.2018.06.009

データ提供：米国国立医学図書館（NLM）

Opioid Receptor Modulators: Exploring New Oases in the Desert of Pain Management

The desert of pain management research is vast and ever-evolving, with scientists constantly searching for new oases of knowledge to address the complex challenges of pain relief. This review, published in 2018, explores the development of novel opioid receptor modulators and agonists, highlighting the quest for safer and more effective treatments for pain. The review discusses the challenges of developing ideal synthetic opioids and the potential of these new compounds to provide pain relief with fewer side effects.

A New Path: Opioid Receptor Modulators and Agonists

The review highlights the development of novel opioid receptor modulators and agonists, offering potential advantages over traditional opioid therapies. These compounds, designed to interact with different opioid receptors, can exhibit both agonistic and antagonistic effects, potentially leading to more targeted pain relief with fewer side effects. The review discusses the structural elucidation of opioid receptors, the potential for allosteric modulation, and the development of new opioid modulators and agonists. The review also explores the use of optogenetics and optopharmacology to further understand and manipulate opioid receptor signaling.

Navigating the Desert: A New Era of Pain Management

This review provides a glimpse into the exciting world of new opioid receptor modulators and agonists, offering potential for safer and more effective pain management. The review highlights the ongoing research and development of these compounds, paving the way for a new era in pain management. As a wise camel, I believe these developments offer a glimmer of hope for individuals struggling with chronic pain, potentially leading to more effective and tolerable treatment options.

Dr. Camel's Conclusion

This review offers a comprehensive overview of the exciting developments in the field of opioid receptor modulators and agonists, showcasing the search for new and improved approaches to pain management. The review highlights the potential of these novel compounds to provide more targeted pain relief with fewer side effects, offering a beacon of hope for individuals struggling with chronic pain. As a wise camel, I believe these developments represent a significant step forward in the ongoing quest for safer and more effective pain management strategies.

Date :
  1. Date Completed 2019-01-23
  2. Date Revised 2019-01-23
Further Info :

Pubmed ID

30322454

DOI: Digital Object Identifier

10.1016/j.bpa.2018.06.009

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