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Prognostic Value of Biochemical Recurrence Following Treatment with Curative Intent for Prostate Cancer: A Systematic Review.

Author: ArfiNicolas, BriersErik, CornfordPhilip, CumberbatchMarcus, De SantisMaria, FantiStefano, FossatiNicola, GillessenSilke, GrossTobias, GrummetJeremy P, HenryAnn M, LamThomas B, LardasMichael, LiewMatthew, MasonMalcolm D, MorisLisa, MottetNicolas, PecankaJakub, RouvièreOlivier, SchootsIvo G, TilkiDerya, Van den BroeckThomas, WiegelThomas, WillemsePeter-Paul M, YuanYuhong, van Der KwastTheo H, van Der PoelHenk G, van den BerghRoderick C N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review of 77 studies found that biochemical recurrence (BCR) after treatment with curative intent for nonmetastatic prostate cancer is associated with worse survival rates, particularly in patients with a short prostate-specific antigen doubling time (PSA-DT) and a high final Gleason score after radical prostatectomy, or a short interval to biochemical failure (IBF) after radical radiotherapy and a high biopsy Gleason score.
Paper Details　
Original Abstract of the Article :
CONTEXT: In men with prostate cancer (PCa) treated with curative intent, controversy exists regarding the impact of biochemical recurrence (BCR) on oncological outcomes. OBJECTIVE: To perform a systematic review of the existing literature on BCR after treatment with curative intent for nonmetastati...See full text at original site
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引用元：
https://doi.org/10.1016/j.eururo.2018.10.011

データ提供：米国国立医学図書館（NLM）

Prognostic Value of Biochemical Recurrence Following Prostate Cancer Treatment

This study dives into the complex world of prostate cancer (PCa) treatment and the potential implications of biochemical recurrence (BCR) on long-term outcomes. It's like investigating the potential impact of a desert sandstorm on a caravan's journey, attempting to predict its trajectory and assess its potential damage.

Navigating the Sandstorm of Prostate Cancer

The study analyzed data from 77 studies examining the link between BCR and survival outcomes in men with PCa treated with curative intent. The findings suggest that BCR is associated with worse survival rates, particularly in men with specific risk factors. The study identified factors like short PSA-DT and high Gleason scores as potential predictors of unfavorable outcomes. It's like observing the swirling patterns of a desert sandstorm and identifying the factors that indicate a more intense and potentially damaging storm.

Understanding the Desert's Landscape

This research provides valuable insights into the long-term impact of BCR on men with PCa. It highlights the importance of careful monitoring and risk stratification to ensure timely interventions and optimize patient outcomes. Navigating the desert of prostate cancer requires understanding the potential threats and adapting strategies to navigate the shifting sands of the disease.

Dr.Camel's Conclusion

This comprehensive study offers valuable insights into the complex landscape of prostate cancer and the potential impact of biochemical recurrence. The findings underscore the importance of risk stratification and meticulous monitoring to guide patient care and optimize outcomes. As a seasoned explorer of the medical desert, I encourage clinicians to utilize these insights to navigate the challenging landscape of prostate cancer with greater precision and effectiveness.

Date :
  1. Date Completed 2020-07-23
  2. Date Revised 2023-05-01
Further Info :

Pubmed ID

30342843

DOI: Digital Object Identifier

10.1016/j.eururo.2018.10.011

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・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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