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Differential inhibitory effects of auranofin on leukotriene B4 and leukotriene C4 formation by human polymorphonuclear leukocytes.

Author: HondaZ, IizasaT, MatsutaK, MiyamotoT, MoritaY, NishidaY

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Auranofin (AF) is an oral gold compound that inhibits leukotriene (LT) formation by human polymorphonuclear leukocytes (PMNs). AF inhibited LTC4 formation more effectively than LTB4 formation, and this differential inhibitory effect may play a role in the efficacy of this drug.
Paper Details　
Original Abstract of the Article :
Auranofin (AF) is a newly introduced oral gold compound having antirheumatic properties, and its efficacy in the treatment of bronchial asthma is now under investigation. In this study, we examined the effects of AF on leukotriene (LT) formation by human polymorphonuclear leukocytes (PMNs) stimulate...See full text at original site
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引用元：
https://doi.org/10.1016/0006-2952(87)90113-4

データ提供：米国国立医学図書館（NLM）

Auranofin: A Gold Standard in Asthma Treatment?

Auranofin, a gold-containing drug used to treat rheumatoid arthritis, shows potential benefits in asthma treatment. This study explores the fascinating effects of Auranofin on leukotriene (LT) formation, crucial inflammatory molecules involved in asthma. This research sheds light on the mechanisms of Auranofin's action and suggests its potential role in asthma treatment.

Auranofin's Selective Inhibition

The study unveils the intriguing selective inhibitory effects of Auranofin on LT formation. While it effectively suppresses LTC4 synthesis, it exhibits a much weaker effect on LTB4 formation. This selective inhibition suggests a targeted approach to treating asthma, potentially mitigating the side effects associated with broader-acting anti-inflammatory medications.

Balancing the Scales of Inflammation

This research suggests a potential new avenue for treating asthma. By selectively targeting LT production, Auranofin could provide relief from asthma symptoms with fewer side effects than traditional treatments. This research is like a shimmering mirage in the desert of asthma research.

Dr.Camel's Conclusion

Auranofin's selective inhibition of LTs in asthma suggests a promising alternative to traditional treatments. It's like a precious pearl unearthed in the vast desert of drug discovery.

Date :
  1. Date Completed 1987-06-25
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

3034290

DOI: Digital Object Identifier

10.1016/0006-2952(87)90113-4

Related Literature

Article Analysis
・Effects of auranofin
SNS
PICO Info
in preparation
Languages

English

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