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Novel Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate-to-Severe Acne Vulgaris: Assessment of Efficacy and Safety in Patients Aged 9 Years and Older.

Author: BhattVarsha, GueninEric, KircikLeon H, PariserDavid M, PillaiRadhakrishnan, TyringStephen K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A pooled analysis of two randomized controlled trials of 1640 patients with moderate-to-severe acne found that tretinoin 0.05% lotion demonstrated statistically significant superiority to vehicle in reducing inflammatory and noninflammatory lesions and improving acne severity. The lotion was also associated with greater patient satisfaction and improved acne-specific quality of life.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Topical tretinoin has been extensively studied in clinical trials, and its essential role in the treatment of acne vulgaris (acne) established through evidence-based guidelines. OBJECTIVE: To evaluate efficacy, safety, and tolerability of a novel tretinoin 0.05% lotion in moderate-to-se...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/30365589

データ提供：米国国立医学図書館（NLM）

Tretinoin 0.05% Lotion: A New Oasis in Acne Treatment

The desert of [acne vulgaris] can be a challenging landscape for those seeking a clear complexion. This study, like a newly discovered oasis, explores the potential of [a novel tretinoin 0.05% lotion] for the treatment of [moderate-to-severe acne] in patients aged [9 years and older]. The researchers embarked on a journey to assess its efficacy, safety, and tolerability, seeking to find a new path to clearer skin.

A New Treatment Emerges: A Beacon of Hope for Acne

The study's findings, like a clear spring in the desert, reveal that [tretinoin 0.05% lotion] significantly outperformed the control treatment in reducing both [inflammatory and noninflammatory] lesions. This treatment also demonstrated a favorable [safety and tolerability] profile, suggesting that it could be a valuable addition to the acne treatment landscape.

Clear Skin: A Desert Oasis

The discovery of an effective and safe treatment for [acne] can be a beacon of hope for individuals struggling with this common skin condition. The findings of this study offer a glimpse of a potential oasis in the desert of acne, where clear skin and improved quality of life may be within reach.

Dr.Camel's Conclusion

The desert of acne research is always looking for new solutions. This study shines a light on [tretinoin 0.05% lotion] as a promising treatment for [acne]. The findings suggest this new oasis could offer relief to those navigating the challenging landscape of acne. While further research is needed to fully understand its long-term effects, the study's results offer a glimmer of hope in the quest for clear and healthy skin.

Date :
  1. Date Completed 2018-12-11
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

30365589

DOI: Digital Object Identifier

S1545961618P1084X

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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