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Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.
Author: AlpiniGianfranco D, AlpiniSally F, DuChristina, FrancisHeather, GashevAnatoliy A, GashevaOlga Y, GobbellCassidy, HargroveLaura, HittAngie R, MeiningerCynthia J, Newell-RogersM Karen, PalSarit, Troyanova-WoodMaria, Tsoy NizamutdinovaIrina, YakovlevVlad V, ZawiejaDavid C
Original Abstract of the Article :
This study aimed to establish mechanistic links between the prolonged intake of desloratadine, a common H1 receptor blocker (i.e., antihistamine), and development of obesity and metabolic syndrome. Male Sprague-Dawley rats were treated for 16 wk with desloratadine. We analyzed the dynamics of body w...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383386/
データ提供:米国国立医学図書館(NLM)
Antihistamines: A Hidden Impact on Weight
Antihistamines are a common medication for allergies, providing relief from itchy eyes, runny nose, and sneezing. But this study explores a surprising potential side effect of long-term antihistamine use: the development of obesity and metabolic syndrome. The researchers investigated the effects of prolonged desloratadine use in rats, finding that it led to weight gain, increased fat accumulation, and changes in blood lipid and glucose levels, suggesting a link between antihistamines and metabolic disorders.
Antihistamines and Metabolism: A Complex Connection
This research reveals a potentially overlooked consequence of long-term antihistamine use. The study suggests that prolonged desloratadine use in rats led to weight gain, fat accumulation, and metabolic disturbances. The researchers found that these changes were linked to dysfunction of mesenteric lymphatic vessels, which play a crucial role in transporting fat and nutrients throughout the body. While more research is needed to confirm these findings in humans, this study raises important questions about the potential metabolic effects of commonly used medications.
Maintaining Metabolic Health: A Balancing Act
The desert of our bodies is a complex ecosystem, and maintaining a healthy balance is crucial. This research highlights the potential metabolic effects of commonly used medications. It's a reminder that while medications can provide valuable relief, they can also have unintended consequences. It's essential to consult with your healthcare provider about potential side effects and to adopt a healthy lifestyle that includes balanced diet, regular exercise, and stress management.
Dr.Camel's Conclusion
This study reminds us that the seemingly simple act of taking a pill can have far-reaching consequences. The desert of our bodies is a complex ecosystem, and even seemingly innocuous substances can disrupt this delicate balance. This research underscores the importance of staying informed about potential side effects and taking a proactive approach to our health.
Date :
- Date Completed 2019-11-19
- Date Revised 2021-10-23
Further Info :
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