Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.

Author: AlpiniGianfranco D, AlpiniSally F, DuChristina, FrancisHeather, GashevAnatoliy A, GashevaOlga Y, GobbellCassidy, HargroveLaura, HittAngie R, MeiningerCynthia J, Newell-RogersM Karen, PalSarit, Troyanova-WoodMaria, Tsoy NizamutdinovaIrina, YakovlevVlad V, ZawiejaDavid C

Paper Details 
Original Abstract of the Article :
This study aimed to establish mechanistic links between the prolonged intake of desloratadine, a common H1 receptor blocker (i.e., antihistamine), and development of obesity and metabolic syndrome. Male Sprague-Dawley rats were treated for 16 wk with desloratadine. We analyzed the dynamics of body w...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383386/

データ提供:米国国立医学図書館(NLM)

Antihistamines: A Hidden Impact on Weight

Antihistamines are a common medication for allergies, providing relief from itchy eyes, runny nose, and sneezing. But this study explores a surprising potential side effect of long-term antihistamine use: the development of obesity and metabolic syndrome. The researchers investigated the effects of prolonged desloratadine use in rats, finding that it led to weight gain, increased fat accumulation, and changes in blood lipid and glucose levels, suggesting a link between antihistamines and metabolic disorders.

Antihistamines and Metabolism: A Complex Connection

This research reveals a potentially overlooked consequence of long-term antihistamine use. The study suggests that prolonged desloratadine use in rats led to weight gain, fat accumulation, and metabolic disturbances. The researchers found that these changes were linked to dysfunction of mesenteric lymphatic vessels, which play a crucial role in transporting fat and nutrients throughout the body. While more research is needed to confirm these findings in humans, this study raises important questions about the potential metabolic effects of commonly used medications.

Maintaining Metabolic Health: A Balancing Act

The desert of our bodies is a complex ecosystem, and maintaining a healthy balance is crucial. This research highlights the potential metabolic effects of commonly used medications. It's a reminder that while medications can provide valuable relief, they can also have unintended consequences. It's essential to consult with your healthcare provider about potential side effects and to adopt a healthy lifestyle that includes balanced diet, regular exercise, and stress management.

Dr.Camel's Conclusion

This study reminds us that the seemingly simple act of taking a pill can have far-reaching consequences. The desert of our bodies is a complex ecosystem, and even seemingly innocuous substances can disrupt this delicate balance. This research underscores the importance of staying informed about potential side effects and taking a proactive approach to our health.

Date :
  1. Date Completed 2019-11-19
  2. Date Revised 2021-10-23
Further Info :

Pubmed ID

30475062

DOI: Digital Object Identifier

PMC6383386

SNS
PICO Info
in preparation
Languages

English

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