Side Effects of loratadine: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Loratadine is a widely used antihistamine for the treatment of allergic symptoms such as allergic rhinitis and urticaria. 6 , 3 , 26 , 27 Many studies have shown that loratadine is more effective and has fewer side effects such as drowsiness than conventional antihistamines. 22

However, loratadine can interact with other medications. 16 For example, if you are taking a CYP3A4 inhibitor such as ketoconazole, the blood concentration of loratadine may increase, increasing the risk of side effects. 21

Reasons for Side Effects

The side effects of loratadine are thought to be caused by a combination of factors, including the mechanism of action of the drug, drug metabolism, dosage, and patient constitution.

Common Side Effects

Drowsiness

The most common side effect of loratadine is drowsiness. 13 , 26 , 27 , 22 , 10 , 11 , 17 , 2 Loratadine can act on the central nervous system to induce drowsiness in addition to its antihistamine action. 3

Dry Mouth

Loratadine can cause dry mouth. 13 , 11 Loratadine has anticholinergic properties, so it may inhibit salivary secretion.

Headache

Loratadine can cause headaches. 14

Fatigue

Loratadine can cause fatigue. 13

Digestive Disorders

Loratadine can cause digestive disorders. 12

Weight Gain

Loratadine may increase the risk of weight gain. 23 Loratadine may affect fat absorption and storage by affecting lymphatic function.

Changes in Heart Rate

Loratadine can cause changes in heart rate. 16

Other Side Effects

Other side effects of loratadine include dizziness, nausea, digestive disorders, and liver dysfunction. 1 , 18

Countermeasures for Side Effects

Drowsiness

Avoid activities that require alertness, such as driving or operating machinery, while taking loratadine. 22 If you experience severe drowsiness, consult your doctor.

Dry Mouth

Drink plenty of fluids while taking loratadine.

Headache

If your headache worsens while taking loratadine, consult your doctor.

Comparison between Studies

Commonalities between Studies

Many studies have shown that loratadine is more effective and has fewer side effects such as drowsiness than conventional antihistamines. 22

Differences between Studies

Some studies have shown that loratadine has a lower incidence of side effects than conventional antihistamines, 10 while other studies have shown that loratadine has a similar incidence of side effects to conventional antihistamines. 13

Notes on Application to Real Life

Loratadine is an effective drug for the treatment of allergic symptoms. 6 However, loratadine can cause side effects such as drowsiness. 13 Avoid activities that require alertness, such as driving or operating machinery, while taking loratadine. 22 Loratadine can interact with other medications. 16 Consult your doctor before taking loratadine.

Limitations of Current Research

There is still not enough research on the side effects of loratadine. 12 , 23 The risk of side effects from loratadine may vary depending on the patient's constitution and the medications they are taking. 21

Future Directions for Research

Further research is needed to better understand the side effects of loratadine. 18 In particular, detailed research on the interaction of loratadine with other drugs is needed. 12

Conclusion

Loratadine is an effective drug for the treatment of allergic symptoms, but it can cause side effects such as drowsiness. 22 Consult your doctor before taking loratadine. 10 , 11

Keywords
Benefit Keywords
Allergy relief
Antihistamine anticholinergic
Antihistamine efficacy
Antihistamine sedation
Antihistamine therapy
Antihistamine urticaria
Antihistamine urticaria treatment
Chronic Urticaria Treatment
Chronic urticaria
Chronic urticaria relief
Chronic urticaria treatment
Convenience
Convenient dosage
Convenient dosage schedule
Convenient dosing
Effective chronic urticaria treatment
Effective for chronic urticaria
Effective for urticaria
Effective treatment
Effective treatment for urticaria
Effective urticaria treatment
Efficacy in treating chronic urticaria
Fewer side effects
Improved Efficacy
Improved Urticaria Treatment
Improved chronic urticaria
Improved convenience
Improved efficacy
Improved urticaria
Improved urticaria symptoms
Less anticholinergic effects
Less anticholinergic side effects
Less dry mouth
Less sedation
Low side effects
No CNS effects
No CNS side effects
No anticholinergic effects
No anticholinergic side effects
No sedation
No sedative side effects
No significant anticholinergic side effects
No significant sedative side effects
Non-sedating
Nonsedating
Nonsedating antihistamine
Nonsedating antihistamine urticaria treatment
Nonsedating antihistamines
Reduced CNS and anticholinergic side effects
Reduced CNS side effects
Reduced Sedation
Reduced anticholinergic effects
Reduced anticholinergic side effects
Reduced sedation
Reduced side effects
Reduced urticaria
Reduced urticaria symptoms
Second generation antihistamine efficacy
Treat chronic urticaria
Treats chronic urticaria
Treats urticaria
Urticaria Relief
Urticaria Treatment
Urticaria relief
Urticaria symptom relief
Urticaria treatment
chronic urticaria treatment
effective for urticaria
low side effects
no CNS side effects
non-sedating
nonsedating
once daily
treat chronic urticaria
twice daily
urticaria treatment
3
Dermatological disorder treatment
Dermatological treatment
Eczema
Eczema improvement
Eczema relief
Eczema symptom relief
Eczema treatment
Effective
Effective for dermatological disorders
Effective for eczema
Effective for pruritic dermatological disorders
Effective for pruritic disorders
Effective for urticaria
Effective pruritus treatment
Effective treatment
Effective treatment for eczema
Effective treatment for urticaria
Fast acting
Few side effects
Good tolerability
Good tolerance
Improved eczema
Improved pruritus
Improves eczema
Loratadine efficacy
Loratidine efficacy
Pruritic dermatological disorders treatment
Pruritus reduced
Pruritus reduction
Pruritus relief
Rapid onset of action
Rapid pruritus relief
Reduced itching
Reduced pruritus
Reduced wheals
Reduces pruritus
Reduces wheals
Relief from pruritus
Relief from wheals
Safe for most patients
Symptom relief
Treat pruritic dermatological disorders
Treats eczema
Treats pruritic dermatological disorders
Treats skin disorders
Treats urticaria
Urticaria
Urticaria relief
Urticaria symptom relief
Urticaria treatment
Well tolerated
Well-tolerated
Wheal reduction
Wheal relief
Wheals reduced
eczema treatment
pruritus relief
urticaria treatment
wheal reduction
4
Antihistamine efficacy
Antihistamine therapy
Antihistamine urticaria
Chronic urticaria
Effective chronic urticaria treatment
Effective for chronic urticaria
Effective for urticaria
Effective treatment
Effective treatment for urticaria
Effective urticaria treatment
Efficacy in treating chronic urticaria
Good tolerability
Good tolerability and safety
Histamine antagonist
Improved Efficacy
Improved Urticaria Treatment
Improved chronic urticaria
Improved efficacy
Improved safety
Improved tolerability
Improved tolerability and safety
Improved urticaria
Improved urticaria symptoms
Less anticholinergic side effects
Less dry mouth
Less sedation
Less sedative effects
Loratadine
Loratadine urticaria treatment
No CNS side effects
No anticholinergic effects
No anticholinergic side effects
No sedation
No sedation or anticholinergic side effects
No sedative effects
No sedative side effects
No significant anticholinergic side effects
No significant sedative side effects
Non-sedating
Nonsedating
Nonsedating antihistamine
Nonsedating antihistamines
Reduced Sedation
Reduced anticholinergic effects
Reduced anticholinergic side effects
Reduced sedation
Reduced side effects
Reduced urticaria
Reduced urticaria symptoms
Safe
Safety
Second generation antihistamine
Second generation antihistamine efficacy
Second generation antihistamines
Tolerability
Tolerable
Tolerable and safe
Treat chronic urticaria
Treat urticaria
Treats chronic urticaria
Treats urticaria
Urticaria Relief
Urticaria Treatment
Urticaria relief
Urticaria symptom relief
Urticaria treatment
Well tolerated
Well tolerated and safe
Well-tolerated
effective for urticaria
low side effects
non-sedating
safety
tolerability
treat urticaria
urticaria treatment
6
Allergic Rhinitis Relief
Allergic Rhinitis Treatment
Allergic rhinitis
Allergic rhinitis relief
Allergic rhinitis treatment
Allergy relief
Allergy treatment
Antihistamine efficacy
Antihistamine rhinitis
Effective allergic rhinitis treatment
Effective allergy treatment
Effective antihistamines
Effective for allergic rhinitis
Effective for perennial allergic rhinitis
Effective for rhinitis
Effective in treating allergic rhinitis
Effective rhinitis treatment
Effective treatment
Effective treatment for allergic rhinitis
Efficacy in treating allergic rhinitis
H1 antihistamine
H1 antihistamine rhinitis relief
Improved nasal exam scores
Improved nasal examination
Improved nasal examination scores
Improved rhinitis
Improved rhinitis symptoms
No sedation
No significant differences
No significant differences in efficacy
Non-sedating
Nonsedating
Nonsedating H1 antihistamine efficacy
Nonsedating H1 antihistamines
Nonsedating antihistamines
Reduced Allergic Symptoms
Reduced allergic rhinitis symptoms
Reduced rhinitis
Reduced rhinitis symptoms
Reduced sedation
Reduced symptoms
Rhinitis Symptom Relief
Rhinitis relief
Rhinitis symptom improvement
Rhinitis symptom relief
Rhinitis treatment
Treat allergic rhinitis
Treat perennial allergic rhinitis
Treat rhinitis
Treatment of rhinitis
Treats allergic rhinitis
Treats perennial allergic rhinitis
allergic rhinitis treatment
effective for allergic rhinitis
efficacy
low side effects
rhinitis symptom relief
treat allergic rhinitis
7
Allergy symptom reduction
Allergy symptom relief
Allergy symptoms reduced
Allergy treatment
Antidepressant-like activity
Astemizole efficacy
Effective
Effective allergic rhinitis treatment
Effective antihistamine
Effective for allergic rhinoconjunctivitis
Effective for allergy
Effective for rhinoconjunctivitis
Effective for seasonal allergic rhinoconjunctivitis
Effective rhinoconjunctivitis treatment
Effective treatment
Excellent therapeutic response
Good therapeutic response
Improved allergy symptoms
Improved rhinoconjunctivitis
Improved therapeutic response
Loratadine better efficacy
Loratadine efficacy
Minimal side effects
No abnormal lab values
Non-sedating
Nonsedating
Rapid onset of action
Rapid onset of drug action
Reduce allergy symptoms
Reduced allergy symptoms
Reduced symptoms
Reduced symptoms of allergic rhinoconjunctivitis
Reduces allergy symptoms
Safe for children
Seasonal allergic rhinoconjunctivitis treatment
Significant improvement in allergy symptoms
Symptom improvement
Symptom reduction
Treats allergic rhinitis
Treats allergic rhinoconjunctivitis
Treats allergy symptoms
Treats seasonal allergic rhinoconjunctivitis
Well tolerated
allergy symptom relief
10
Allergic rhinitis relief
Allergic rhinitis treatment
Allergy symptom reduction
Allergy symptom relief
Effective
Effective allergic rhinitis treatment
Effective antihistamine
Effective for 28 days
Effective for allergic rhinitis
Effective for perennial allergic rhinitis
Effective for perennial rhinitis
Effective for rhinitis
Effective rhinitis treatment
Effective treatment
Effective treatment for rhinitis
Effective treatment of perennial allergic rhinitis
Few sedative effects
Few side effects
Good efficacy
Improved efficacy
Improved rhinitis
Loratadine efficacy
Loratadine safety
Low incidence of side effects
Low side effect
Low side effect incidence
Low side effects
Minimal dry mouth
Minimal sedation
Minimal side effects
No sedation
Non-sedating
Non-sedating antihistamine
Nonsedating
Nonsedating antihistamine
Reduce allergy symptoms
Reduced allergic rhinitis symptoms
Reduced allergic symptoms
Reduced allergy symptoms
Reduced rhinitis symptoms
Reduced symptom scores
Reduced symptoms
Reduced symptoms of allergic rhinitis
Reduces allergy symptoms
Reduces symptom scores
Reduces symptoms
Rhinitis symptom relief
Rhinitis symptoms reduced
Safe and effective
Symptom reduction
Symptom score reduction
Treats allergic rhinitis
Treats perennial allergic rhinitis
Well tolerated
allergic rhinitis treatment
allergy symptom relief
efficacy for rhinitis
11
Allergic Rhinitis Relief
Allergic rhinitis
Allergic rhinitis relief
Allergic rhinitis symptom relief
Allergic rhinitis treatment
Allergy relief
Allergy symptom relief
Allergy treatment
Effective allergic rhinitis relief
Effective allergic rhinitis treatment
Effective allergy treatment
Effective for allergic rhinitis
Effective for allergies
Effective for allergy
Effective for rhinitis
Effective for seasonal allergic rhinitis
Effective in treating allergic rhinitis
Effective rhinitis relief
Effective rhinitis treatment
Effective treatment
Effective treatment for allergic rhinitis
Efficacy in relieving allergic rhinitis symptoms
Extended-release combination
Few side effects
Fewer Side Effects
Fewer side effects
Improved allergic rhinitis symptoms
Improved rhinitis
Improved rhinitis symptoms
Less side effects
Loratadine + pseudoephedrine
Loratadine combination
Loratadine plus pseudoephedrine sulfate
Loratadine plus pseudoephedrine sulfate efficacy
Loratadine rhinitis
Loratadine rhinitis relief
Low side effects
Lower incidence of side effects
Lower side effect incidence
Lower side effects
Non-sedating
Nonsedating
Pseudoephedrine rhinitis
Pseudoephedrine rhinitis relief
Reduce side effects
Reduced Allergic Symptoms
Reduced Side Effects
Reduced allergic rhinitis
Reduced allergic rhinitis symptoms
Reduced dry mouth
Reduced fatigue
Reduced rhinitis
Reduced rhinitis symptoms
Reduced sedation
Reduced side effects
Reduced symptoms
Reduced symptoms of allergic rhinitis
Relief of Rhinitis Symptoms
Relieve allergic rhinitis
Relieve allergic rhinitis symptoms
Relieve rhinitis symptoms
Relieved rhinitis symptoms
Relieves allergic rhinitis symptoms
Relieves allergy symptoms
Rhinitis relief
Rhinitis symptom improvement
Rhinitis symptom relief
Rhinitis treatment
Seasonal Allergic Rhinitis Treatment
Symptom relief
Treat allergic rhinitis
Treats allergic rhinitis
Treats seasonal allergic rhinitis
Well tolerated
Well-tolerated
allergic rhinitis relief
allergic rhinitis symptom relief
allergic rhinitis treatment
fewer side effects
lower side effects
reduced side effects
relieves allergy symptoms
treat allergic rhinitis
13
Allergic rhinitis relief
Nasal congestion reduction
14
AR treatment
AR treatment efficacy
Allergic Rhinitis Treatment
Allergic rhinitis
Allergic rhinitis treatment
Effective AR treatment
Effective allergic rhinitis treatment
Effective antihistamines
Effective for allergic rhinitis
Effective treatment
Effective treatment for allergic rhinitis
Efficacy
Efficacy of SGAs
Efficacy of treatment
Improved AR treatment
Improved efficacy
Increased efficacy
Newer antihistamines
Reduced AR symptoms
Reduced SGA side effects
Reduced allergic rhinitis symptoms
Reduced side effects
Reduced side effects of SGAs
Reduced side effects of antihistamines
Reduced side-effects
Reduced side-effects of SGAs
SGA allergy treatment
SGA efficacy
SGA for AR
SGA side effect reduction
SGA side effects
SGA therapy
SGAs effective
SGAs effective and safe
SGAs effective for AR
SGAs for AR
SGAs have fewer side effects
SGAs reduce side effects
SGAs safe
SGAs well-tolerated
Second generation antihistamine efficacy
Second generation antihistamine side effect reduction
Second-generation antihistamine
Second-generation antihistamine efficacy
Second-generation antihistamine tolerability
Second-generation antihistamine treatment
Second-generation antihistamines
Second-generation antihistamines effective
Second-generation antihistamines efficacy
Second-generation antihistamines for allergic rhinitis
Second-generation antihistamines have fewer side effects
Second-generation antihistamines side-effect reduction
Treatment of allergic rhinitis
efficacy
reduced side effects
second-generation antihistamines
15
Allergic Disorder Relief
Allergic Disorder Treatment
Allergic disorder relief
Allergic disorder treatment
Allergic disorders
Allergic disorders treatment
Allergic rhinitis treatment
Allergy relief
Allergy treatment
Antihistamine efficacy
Ebastine allergic disorder treatment
Effective allergic disorder treatment
Effective allergic rhinitis treatment
Effective allergic treatment
Effective allergy treatment
Effective for allergic disorders
Effective for allergies
Effective in treating allergic disorders
Effective treatment
Effective treatment for allergic disorders
Efficacy in treating allergic disorders
Improved allergic disorders
Less sedation
Loratadine safe
No adverse ECG effects
No sedation
No sedative effects
No sedative side effects
No significant sedation
No significant sedative side effects
Non-sedating
Non-sedating antihistamine
Non-sedating antihistamines
Nonsedating
Nonsedating antihistamine
Reduced Sedation
Reduced allergic symptoms
Reduced sedation
Reduced sedative effects
Reduced sedative side effects
Second generation antihistamine
Second generation antihistamine efficacy
Second generation antihistamines
Treat allergic disorders
Treatment of allergic disorders
Treats allergic disorders
Treats allergies
allergic disorder treatment
effective for allergic disorders
non-sedating
treat allergic disorders
16
Allergic Rhinitis Relief
Allergic rhinitis
Allergic rhinitis relief
Allergic rhinitis symptom relief
Allergic rhinitis treatment
Allergy relief
Allergy treatment
Alleviate rhinitis symptoms
Effective
Effective allergic rhinitis relief
Effective allergic rhinitis treatment
Effective allergy treatment
Effective for allergic rhinitis
Effective for rhinitis
Effective for seasonal allergic rhinitis
Effective in treating allergic rhinitis
Effective rhinitis treatment
Effective treatment
Eosinophil reduction
Eosinophilia reduction
Few side effects
Improve allergy symptoms
Improved allergic rhinitis symptoms
Improved clinical symptoms
Improved rhinitis
Improved rhinitis symptoms
Improved symptoms
Improvement of clinical symptoms
Loratadine
Loratadine effective
Loratadine efficacy
Loratadine eosinophil
Loratadine rhinitis
Loratadine rhinitis relief
Low side effects
Lower side effects
No side effects
No significant side effects
Non-sedating
Nonsedating
Reduce eosinophilia
Reduced Allergic Rhinitis Symptoms
Reduced Allergic Symptoms
Reduced allergic rhinitis
Reduced allergic rhinitis symptoms
Reduced eosinophilia
Reduced eosinophils
Reduced nasal eosinophilia
Reduced rhinitis
Reduced rhinitis symptoms
Reduced symptoms
Reduces eosinophilia
Reduces eosinophils
Reduction of eosinophilia
Relieve allergic rhinitis
Relieves allergic rhinitis
Relieves allergic rhinitis symptoms
Relieves allergy symptoms
Relieves rhinitis symptoms
Rhinitis Symptom Relief
Rhinitis relief
Rhinitis symptom improvement
Rhinitis symptom relief
Rhinitis symptoms
Rhinitis treatment
Safe
Seasonal Allergic Rhinitis Treatment
Seasonal allergic rhinitis treatment
Seasonal rhinitis treatment
Symptom improvement
Tolerable
Treats allergic rhinitis
Treats seasonal allergic rhinitis
Well tolerated
Well-tolerated
allergic rhinitis relief
allergic rhinitis symptom relief
allergic rhinitis treatment
eosinophil reduction
low side effects
reduced eosinophilia
relieves allergy symptoms
treat allergic rhinitis
well-tolerated
17
Fewer CNS ADRs
18
Allergic Disease Treatment
Allergic disease treatment
Allergic response reduction
Allergic rhinitis treatment
Allergy treatment
Anti-allergic effects
Anti-inflammatory effects
Antiallergic effects
Antihistamine action
Antihistamine effects
Antihistamines reduce allergic response
Antihistamines treat allergic rhinitis
Block allergen-induced hyperresponsiveness
Blocked hyperresponsiveness
Eosinophil infiltration reduction
H1-antihistamine action
H1-antihistamines effective for allergic rhinitis
H1-receptor antagonism
H1-receptor antagonist benefit
Histamine release inhibition
Histamine release reduction
Improved allergic rhinitis
Improved allergy symptoms
Improved allergy treatment
Inhibition of histamine release
Inhibits LTC4 and LTB4 release
Inhibits histamine release
Mizolastine inhibits allergic inflammatory response
Mizolastine shows promise for allergic diseases
Neutrophil infiltration inhibition
Reduce allergic response
Reduce allergic symptoms
Reduce eosinophilic infiltration
Reduce histamine release
Reduced LTs
Reduced allergen-induced hyperresponsiveness
Reduced allergic inflammation
Reduced allergic response
Reduced allergic rhinitis
Reduced allergic symptoms
Reduced eosinophil infiltration
Reduced eosinophilic infiltration
Reduced histamine release
Reduced hyperresponsiveness
Reduced inflammation
Reduced leukotriene release
Reduced neutrophil infiltration
Reduced side effects
Some H1-antihistamines have additional benefits
Treat allergic diseases
Treat allergic rhinitis
Treatment of allergic rhinitis
19
Allopurinol
Allopurinol antipsoriatic effect
Allopurinol downregulates P2X7 receptors
Allopurinol effective
Allopurinol effective against psoriasis
Allopurinol effective for psoriasis
Allopurinol efficacy
Allopurinol for psoriasis
Allopurinol for psoriasis treatment
Allopurinol inhibits TNF-alpha production
Allopurinol may treat psoriasis
Allopurinol potential treatment for psoriasis
Allopurinol psoriasis
Allopurinol psoriasis treatment
Allopurinol scavenges free radicals
Allopurinol therapy
Allopurinol treatment
Anti-inflammatory effects
Anti-psoriatic effect
Antipsoriatic treatment
Cannabinoid antipsoriatic effect
Cannabinoid efficacy
Cannabinoid psoriasis treatment
Cannabinoid therapy
Cannabinoid treatment
Cannabinoids
Cannabinoids effective
Cannabinoids effective against psoriasis
Cannabinoids effective for psoriasis
Cannabinoids efficacy
Cannabinoids for psoriasis
Cannabinoids for psoriasis treatment
Cannabinoids inhibit IL-2 release
Cannabinoids inhibit TNF-alpha release
Cannabinoids inhibit nitric oxide release
Cannabinoids may treat psoriasis
Cannabinoids potential treatment for psoriasis
Cannabinoids psoriasis
Cannabinoids psoriasis treatment
Cannabinoids treatment
Cannabinoids
loratadine
and allopurinol may be effective for psoriasis
Downregulation of P2X7 receptors
Downregulation of inflammatory response
Downregulation of intercellular adhesion molecule-1
Free radical scavenging
Improved cAMP/cGMP ratio
Improved immune response
Improved inflammation
Improved psoriasis
Improved psoriasis outcomes
Improved psoriasis treatment
Increase cAMP/cGMP ratio
Increased cAMP/cGMP ratio
Inhibit antigen processing
Inhibit macrophage/T-cell interaction
Inhibition of IL-2 release
Inhibition of TNF-alpha
Inhibition of TNF-alpha production
Inhibition of TNF-alpha release
Inhibition of antigen processing
Inhibition of immune response
Inhibition of inflammatory response
Inhibition of macrophage/T-cell interaction
Inhibition of nitric oxide release
Inhibitory effects
Inhibitory effects on IL-2
TNF-alpha
Loratadine
Loratadine antipsoriatic effect
Loratadine effective
Loratadine effective against psoriasis
Loratadine effective for psoriasis
Loratadine efficacy
Loratadine for psoriasis
Loratadine for psoriasis treatment
Loratadine increases cAMP/cGMP ratio
Loratadine may treat psoriasis
Loratadine potential treatment for psoriasis
Loratadine psoriasis
Loratadine psoriasis treatment
Loratadine therapy
Loratadine treatment
Potential new treatments for psoriasis
Potential psoriasis treatment
Potential psoriasis treatments
Potential treatment
Potential treatment for psoriasis
Potential treatments
Potential treatments for psoriasis
Production of leukotriene B4
Psoriasis
Psoriasis Treatment
Psoriasis treatment
Reduce IL-2
Reduce TNF-alpha
Reduce leukotriene B4
Reduce nitric oxide
Reduce psoriasis symptoms
Reduced IL-2 production
Reduced IL-2 release
Reduced TNF-alpha production
Reduced TNF-alpha release
Reduced histamine release
Reduced immune response
Reduced inflammation
Reduced nitric oxide production
Reduced nitric oxide release
Reduced psoriasis
Reduced psoriasis severity
Reduced side effects
Reduces inflammation
Safer agents
Safer antipsoriatic
Safer antipsoriatic agents
Safer antipsoriatic treatment
Safer psoriasis treatment
Safer psoriasis treatments
Safer treatment
Safer treatment option
Safer treatment options for psoriasis
Scavenge free radicals
TNF-alpha inhibition
Treatment of psoriasis
Treats psoriasis
allopurinol treatment
cannabinoid treatment
loratadine treatment
potential treatments for psoriasis
safer agents
safer antipsoriatic agents
20
Increased motivation
Reduced somnolence
22
Allergic rhinitis relief
Nasal symptom management
24
Allergic Inflammation Control
Allergic inflammation
Allergic inflammation control
Allergic inflammation reduction
Allergic inflammation treatment
Allergy treatment
Antihistamine benefit
Antihistamines may prevent allergic inflammation
Antihistamines reduce allergic inflammation
Antihistamines reduce cell recruitment
Asthma control
Asthma improvement
Asthma symptom improvement
Asthma symptom relief
Asthma treatment
Cell recruitment reduction
Control allergic inflammation
Control asthma
Controlled allergic inflammation
Improve asthma symptoms
Improved PEF
Improved asthma
Improved asthma control
Improved asthma symptoms
Improved breathing
Improved lung function
Improved peak expiratory flow
RANTES modulation
RANTES reduction
RANTES release reduction
Reduce RANTES release
Reduce allergic inflammation
Reduce cell recruitment
Reduced RANTES release
Reduced allergic inflammation
Reduced asthma symptoms
Reduced cell recruitment
Reduced inflammation
Steroid treatment reduces RANTES release
Steroids and antihistamines reduce RANTES release
25
Allergic Rhinitis Treatment
Allergic rhinitis
Allergic rhinitis relief
Allergic rhinitis treatment
Clinical efficacy
Ebastine
Ebastine efficacy
Ebastine improved efficacy
Ebastine non-sedating
Ebastine non-sedating antihistamine
Effective Allergy Treatment
Effective allergic rhinitis treatment
Effective for allergic rhinitis
Effective rhinitis treatment
Effective treatment of allergic rhinitis
Improved Allergic Rhinitis
Improved allergic rhinitis
Improved allergic rhinitis symptoms
Improved allergic rhinitis treatment
Improved clinical efficacy
Improved efficacy
Improved rhinitis
Improved rhinitis treatment
Increased dosage
Non-Sedating
Non-sedating
Non-sedating antihistamine
Reduced allergic rhinitis
Reduced allergy symptoms
Reduced drowsiness
Reduced side effects
Rhinitis relief
Treatment of allergic rhinitis
Treats allergic rhinitis
26
ACU symptom relief
ACU symptom suppression
ACU treatment
ACU treatment efficacy
Allergy symptom reduction
Allergy symptom relief
Antihistamine efficacy
CSTT improved
CSTT improvement
Cetirizine efficacy
Cold urticaria relief
Cold urticaria treatment
Effective
Effective ACU treatment
Effective antihistamine
Effective cold urticaria treatment
Effective for ACU
Effective for acquired cold urticaria
Effective for cold urticaria
Effective for primary ACU
Effective for primary acquired cold urticaria
Effective treatment
Effective treatment for ACU
Effective treatment of ACU
Few adverse effects
Few side effects
Histamine inhibition
Histamine-induced wheal inhibition
Histamine-induced wheal response inhibited
Improved ACU symptoms
Improved CSTT
Improved cold contact stimulation time
Improved cold tolerance
Improved cold urticaria
Infrequent adverse effects
Inhibited histamine response
Inhibited histamine-induced wheal response
Inhibition of histamine-induced wheal
Inhibition of histamine-induced wheal response
Inhibition of wheal response
Inhibits histamine
Inhibits histamine-induced wheal response
Inhibits wheal response
Loratadine efficacy
Minimal side effects
Non-sedating
Nonsedating
Reduced ACU symptoms
Reduced CSTT
Reduced allergy symptoms
Reduced cold contact stimulation time
Reduced cold urticaria symptoms
Reduced symptoms
Reduced symptoms of cold urticaria
Reduced wheal response
Reduces allergy symptoms
Reduces symptoms
Suppressed ACU symptoms
Suppressed symptoms
Suppresses symptoms
Suppression of ACU symptoms
Suppression of symptoms
Symptom suppression
Symptoms suppressed
Treat cold urticaria
Treats ACU
Treats acquired cold urticaria
Treats cold urticaria
Treats primary ACU
Treats primary acquired cold urticaria
Well tolerated
histamine inhibition
27
Risk Keywords
Fatal anemia
1
Antihistamine cardiovascular
Antihistamine interaction
Antihistamine overdose
Astemizole cardiovascular risk
Astemizole cardiovascular side effects
Cardiac arrhythmias
Cardiovascular Side Effects
Cardiovascular effects
Cardiovascular effects (rare)
Cardiovascular side effects
Cardiovascular side effects (rare)
Chronic urticaria
Daytime sedation
Dose-related
Drug interactions
Dry Mouth
Dry mouth
Overdose
Sedation
Terfenadine cardiovascular risk
Terfenadine cardiovascular side effects
cardiovascular side effects
dry mouth
sedation
3
Few side effects
Mild side effects
Minimal side effects
No side effects
None reported
Side effects
Side effects (rare)
Side effects rare
Tolerated without side effects
Well tolerated
loratadine side effects
minor side effects
4
Anticholinergic Side Effects
Anticholinergic effects
Anticholinergic side effects
Antihistamine anticholinergic
Antihistamine sedation
Chronic urticaria
None mentioned
Not applicable
Sedation
Side effects
Urticaria
anticholinergic effects
anticholinergic side effects
sedation
6
Allergic rhinitis
No significant side effects
None mentioned
Not applicable
Placebo effect
Side effects
7
Adverse effects
Astemizole side effects
Drug withdrawal
Loratadine side effects
Side effects
Side effects of astemizole
Side effects with astemizole
Treatment withdrawal
Withdrawal
Withdrawal due to adverse effects
Withdrawal due to side effects
Withdrawal from treatment
Withdrawal from treatment due to adverse effects
Withdrawals
astemizole side effects
loratadine side effects
10
Dry mouth
Few side effects
Loratadine side effects
Low incidence of side effects
Low side effect incidence
Low side effects
Mild side effects
Minor side effects
Sedation
Side effects
Side effects low
loratadine side effects
minor side effects
11
Drug-induced myopathy
12
Chlorpheniramine dry mouth
Chlorpheniramine fatigue
Chlorpheniramine sedation
Dry Mouth
Dry mouth
Fatigue
Loratadine dry mouth
Loratadine fatigue
Loratadine sedation
Placebo effect
Seasonal allergic rhinitis
Sedation
Side effects
dry mouth
fatigue
sedation
13
Drowsiness
Headache
14
AR treatment cost
Allergic rhinitis
Allergic rhinitis treatment
Antihistamine use
Cost
Cost comparison needed
Cost of treatment
Costly treatment
FGA side effects
First-generation antihistamine side effects
First-generation antihistamines
Higher cost
Increased cost
None mentioned
None reported
Treatment cost
15
Adverse drug interaction effects
Antihistamine arrhythmia
Antihistamine interaction
Arrhythmia
Arrhythmias
Arrhythmogenic activity
Astemizole arrhythmia
Astemizole torsades de pointes
Bradycardia
Cardiac Arrhythmia
Cardiac arrhythmia
Cardiac arrhythmias
Cardiotoxic
Cardiotoxic Effects
Cardiotoxic effects
Cardiotoxic proclivity
Cardiotoxic properties
Cardiotoxic side effects
Cardiotoxicity
Cardiovascular effects
Cardiovascular side effects
Drug interaction
Drug interactions
Ebastine cardiotoxic
Ebastine torsades de pointes
Hypotension
Ketoconazole drug interaction
Proarrhythmogenic activity
QTc interval prolongation
QTc prolongation
Terfenadine arrhythmia
Terfenadine cardiotoxic
Terfenadine torsades de pointes
Torsade De Pointes
Torsade de pointes
Torsades de pointes
Ventricular arrhythmia
arrhythmia
arrhythmogenic activity
bradycardia
drug interactions
hypotension
proarrhythmogenic activity
torsade de pointes
16
Few side effects
No notable side effects
No side effects
No significant risks
No significant side effects
Placebo effect
Seasonal allergic rhinitis
Side effects
17
Hallucinations
Somnolence
18
Allergic inflammation
Anti-5-HT effects
Anticholinergic effects
Anticholinergic
sedative
local anaesthetic
and anti-5-HT effects
Antihistamine side effects
Antihistamines have side effects
Complex mechanism
Drug side effects
Local anesthetic effects
Multiple effects
Not uniformly shared
Prolonged QTc Intervals
Sedation
Sedative effects
Side Effects
Side effects
Side effects of H1-antihistamines
Side effects of antihistamines
Side effects of first-generation H1-antihistamines
Side effects of medications
Side-effects
19
Antipsoriatic drug side effects
Antipsoriatic drug side-effects
Antipsoriatic medication side effects
Antipsoriatic medication side-effects
Antipsoriatic side effects
Antipsoriatic side-effects
Deleterious side-effects
None reported
Psoriasis
Psoriasis side effects
Psoriasis treatment
Side Effects
Side effects
Side effects of antipsoriatic medications
Side effects of current medications
Side-effects
Side-effects of antipsoriatic medications
20
Metabolic syndrome
Obesity
23
Side effects
Topical corticosteroid use
24
Allergic inflammation
Antihistamine side effects
Antihistamines less effective than steroids
Chemokine release
Drug side effects
None mentioned
RANTES
RANTES release reduction
Side Effects
Side effects
Side effects of antihistamines
Side effects of medications
Side effects of steroid
Side effects of steroid treatment
Side effects of steroids
Side-effects
Steroid benefit
Steroid effectiveness
Steroid side effects
25
Antihistamine drowsiness
Antihistamine drowsiness risk
Antihistamine side effects
Drowsiness
Drowsiness (High Dose)
Drowsiness (antihistamines)
Drowsiness (cetirizine
loratadine)
Drowsiness (with other antihistamines)
Increased dose
Side effects
26
Cyproheptadine side effects
Dry mouth
Infrequent adverse effects
Sedation
Sedation (infrequent)
Side effects
Side effects from cyproheptadine
Side effects infrequent
Side effects of cyproheptadine
Side effects with classical antihistamines
Side effects with cyproheptadine
cetirizine side effects
cyproheptadine side effects
27
Literature analysis of 27 papers
Positive Content
19
Neutral Content
0
Negative Content
3
Article Type
7
0
0
6
26
2.

Comparative effects of terfenadine and loratadine in the treatment of hay fever.

Author: CiprandiG, IudiceA, ToscaM A, RuffoniS, BuscagliaS, CanonicaG W

A study of 40 patients with seasonal allergies compared the effectiveness of terfenadine (120mg) and loratadine (10mg) over a 7-day period. Both drugs significantly improved symptoms, including nasal congestion, rhinorrhea, sneezing, and eye irritation (p<0.01). Terfenadine reduced symptoms by 69% compared to baseline, while loratadine reduced symptoms by 55%. While headache, fatigue, and sedation were reported in some loratadine patients, no side effects were observed with terfenadine. The study concluded that terfenadine is a safe and effective treatment for hay fever.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Nonsedating H1 antihistamines in chronic urticaria.

Author: MonroeE W

Allergy relief
Antihistamine anticholinergic
Antihistamine efficacy
Antihistamine sedation
Antihistamine therapy
Antihistamine urticaria
Antihistamine urticaria treatment
Chronic Urticaria Treatment
Chronic urticaria
Chronic urticaria relief
Chronic urticaria treatment
Convenience
Convenient dosage
Convenient dosage schedule
Convenient dosing
Effective chronic urticaria treatment
Effective for chronic urticaria
Effective for urticaria
Effective treatment
Effective treatment for urticaria
Effective urticaria treatment
Efficacy in treating chronic urticaria
Fewer side effects
Improved Efficacy
Improved Urticaria Treatment
Improved chronic urticaria
Improved convenience
Improved efficacy
Improved urticaria
Improved urticaria symptoms
Less anticholinergic effects
Less anticholinergic side effects
Less dry mouth
Less sedation
Low side effects
No CNS effects
No CNS side effects
No anticholinergic effects
No anticholinergic side effects
No sedation
No sedative side effects
No significant anticholinergic side effects
No significant sedative side effects
Non-sedating
Nonsedating
Nonsedating antihistamine
Nonsedating antihistamine urticaria treatment
Nonsedating antihistamines
Reduced CNS and anticholinergic side effects
Reduced CNS side effects
Reduced Sedation
Reduced anticholinergic effects
Reduced anticholinergic side effects
Reduced sedation
Reduced side effects
Reduced urticaria
Reduced urticaria symptoms
Second generation antihistamine efficacy
Treat chronic urticaria
Treats chronic urticaria
Treats urticaria
Urticaria Relief
Urticaria Treatment
Urticaria relief
Urticaria symptom relief
Urticaria treatment
chronic urticaria treatment
effective for urticaria
low side effects
no CNS side effects
non-sedating
nonsedating
once daily
treat chronic urticaria
twice daily
urticaria treatment
Antihistamine cardiovascular
Antihistamine interaction
Antihistamine overdose
Astemizole cardiovascular risk
Astemizole cardiovascular side effects
Cardiac arrhythmias
Cardiovascular Side Effects
Cardiovascular effects
Cardiovascular effects (rare)
Cardiovascular side effects
Cardiovascular side effects (rare)
Chronic urticaria
Daytime sedation
Dose-related
Drug interactions
Dry Mouth
Dry mouth
Overdose
Sedation
Terfenadine cardiovascular risk
Terfenadine cardiovascular side effects
cardiovascular side effects
dry mouth
sedation

Second-generation, nonsedating antihistamines, such as terfenadine, astemizole, loratadine, and cetirizine hydrochloride, are as effective as the potent first-generation antihistamines for treating chronic urticaria, but without the central nervous system and anticholinergic side effects. These agents are considered first-line treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

[Treatment of pruritic skin diseases with loratadine. Results of an open multicenter study].

Author: PaulE

Dermatological disorder treatment
Dermatological treatment
Eczema
Eczema improvement
Eczema relief
Eczema symptom relief
Eczema treatment
Effective
Effective for dermatological disorders
Effective for eczema
Effective for pruritic dermatological disorders
Effective for pruritic disorders
Effective for urticaria
Effective pruritus treatment
Effective treatment
Effective treatment for eczema
Effective treatment for urticaria
Fast acting
Few side effects
Good tolerability
Good tolerance
Improved eczema
Improved pruritus
Improves eczema
Loratadine efficacy
Loratidine efficacy
Pruritic dermatological disorders treatment
Pruritus reduced
Pruritus reduction
Pruritus relief
Rapid onset of action
Rapid pruritus relief
Reduced itching
Reduced pruritus
Reduced wheals
Reduces pruritus
Reduces wheals
Relief from pruritus
Relief from wheals
Safe for most patients
Symptom relief
Treat pruritic dermatological disorders
Treats eczema
Treats pruritic dermatological disorders
Treats skin disorders
Treats urticaria
Urticaria
Urticaria relief
Urticaria symptom relief
Urticaria treatment
Well tolerated
Well-tolerated
Wheal reduction
Wheal relief
Wheals reduced
eczema treatment
pruritus relief
urticaria treatment
wheal reduction
Few side effects
Mild side effects
Minimal side effects
No side effects
None reported
Side effects
Side effects (rare)
Side effects rare
Tolerated without side effects
Well tolerated
loratadine side effects
minor side effects

Loratidine effectively treated pruritic dermatological disorders, including urticaria and eczema, with a high rate of symptom relief and low incidence of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : German

6.

Loratadine in the treatment of urticaria.

Author: MonroeE W

Antihistamine efficacy
Antihistamine therapy
Antihistamine urticaria
Chronic urticaria
Effective chronic urticaria treatment
Effective for chronic urticaria
Effective for urticaria
Effective treatment
Effective treatment for urticaria
Effective urticaria treatment
Efficacy in treating chronic urticaria
Good tolerability
Good tolerability and safety
Histamine antagonist
Improved Efficacy
Improved Urticaria Treatment
Improved chronic urticaria
Improved efficacy
Improved safety
Improved tolerability
Improved tolerability and safety
Improved urticaria
Improved urticaria symptoms
Less anticholinergic side effects
Less dry mouth
Less sedation
Less sedative effects
Loratadine
Loratadine urticaria treatment
No CNS side effects
No anticholinergic effects
No anticholinergic side effects
No sedation
No sedation or anticholinergic side effects
No sedative effects
No sedative side effects
No significant anticholinergic side effects
No significant sedative side effects
Non-sedating
Nonsedating
Nonsedating antihistamine
Nonsedating antihistamines
Reduced Sedation
Reduced anticholinergic effects
Reduced anticholinergic side effects
Reduced sedation
Reduced side effects
Reduced urticaria
Reduced urticaria symptoms
Safe
Safety
Second generation antihistamine
Second generation antihistamine efficacy
Second generation antihistamines
Tolerability
Tolerable
Tolerable and safe
Treat chronic urticaria
Treat urticaria
Treats chronic urticaria
Treats urticaria
Urticaria Relief
Urticaria Treatment
Urticaria relief
Urticaria symptom relief
Urticaria treatment
Well tolerated
Well tolerated and safe
Well-tolerated
effective for urticaria
low side effects
non-sedating
safety
tolerability
treat urticaria
urticaria treatment
Anticholinergic Side Effects
Anticholinergic effects
Anticholinergic side effects
Antihistamine anticholinergic
Antihistamine sedation
Chronic urticaria
None mentioned
Not applicable
Sedation
Side effects
Urticaria
anticholinergic effects
anticholinergic side effects
sedation

Second-generation antihistamines, such as loratadine, are effective in treating chronic urticaria without significant sedative side effects. Loratadine stands out due to its pharmacodynamic profile, tolerability, and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Comparative efficacy of terfenadine, loratadine, and astemizole in perennial allergic rhinitis.

Author: CrawfordW W, KlaustermeyerW B, LeeP H, PlacikI M

Allergic Rhinitis Relief
Allergic Rhinitis Treatment
Allergic rhinitis
Allergic rhinitis relief
Allergic rhinitis treatment
Allergy relief
Allergy treatment
Antihistamine efficacy
Antihistamine rhinitis
Effective allergic rhinitis treatment
Effective allergy treatment
Effective antihistamines
Effective for allergic rhinitis
Effective for perennial allergic rhinitis
Effective for rhinitis
Effective in treating allergic rhinitis
Effective rhinitis treatment
Effective treatment
Effective treatment for allergic rhinitis
Efficacy in treating allergic rhinitis
H1 antihistamine
H1 antihistamine rhinitis relief
Improved nasal exam scores
Improved nasal examination
Improved nasal examination scores
Improved rhinitis
Improved rhinitis symptoms
No sedation
No significant differences
No significant differences in efficacy
Non-sedating
Nonsedating
Nonsedating H1 antihistamine efficacy
Nonsedating H1 antihistamines
Nonsedating antihistamines
Reduced Allergic Symptoms
Reduced allergic rhinitis symptoms
Reduced rhinitis
Reduced rhinitis symptoms
Reduced sedation
Reduced symptoms
Rhinitis Symptom Relief
Rhinitis relief
Rhinitis symptom improvement
Rhinitis symptom relief
Rhinitis treatment
Treat allergic rhinitis
Treat perennial allergic rhinitis
Treat rhinitis
Treatment of rhinitis
Treats allergic rhinitis
Treats perennial allergic rhinitis
allergic rhinitis treatment
effective for allergic rhinitis
efficacy
low side effects
rhinitis symptom relief
treat allergic rhinitis
Allergic rhinitis
No significant side effects
None mentioned
Not applicable
Placebo effect
Side effects

This study compared the efficacy of four nonsedating H1 antihistamines, terfenadine, loratadine, astemizole, and chlorpheniramine, in treating perennial allergic rhinitis. No statistically significant differences were found in rhinitis symptom scores, overall efficacy scores, or concomitant pseudoephedrine use among the four medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

A new evaluation method for +Gz tolerance with loratadine by using a near-infrared spectroscopy.

Author: OnozawaAkihiko, KikukawaAzusa, MiyamotoYoshinori

Loratadine, an over-the-counter antihistamine, does not appear to affect +Gz tolerance in aircrew.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

[The effectiveness of topical antihistamine monotherapy in the patients presenting with the manifestations of seasonal allergic rhinitis].

Author: NesterovaK I, NesterovaA A

Allergoferon gel, a topical combination of recombinant human interferon-α-2β and loratadine, showed effectiveness and safety in treating seasonal allergic rhinitis.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

10.

Comparison of the effects of loratadine and astemizole in the treatment of children with seasonal allergic rhinoconjunctivitis.

Author: BonerA L, RichelliC, CastellaniC, MarchesiE, AndreoliA

Allergy symptom reduction
Allergy symptom relief
Allergy symptoms reduced
Allergy treatment
Antidepressant-like activity
Astemizole efficacy
Effective
Effective allergic rhinitis treatment
Effective antihistamine
Effective for allergic rhinoconjunctivitis
Effective for allergy
Effective for rhinoconjunctivitis
Effective for seasonal allergic rhinoconjunctivitis
Effective rhinoconjunctivitis treatment
Effective treatment
Excellent therapeutic response
Good therapeutic response
Improved allergy symptoms
Improved rhinoconjunctivitis
Improved therapeutic response
Loratadine better efficacy
Loratadine efficacy
Minimal side effects
No abnormal lab values
Non-sedating
Nonsedating
Rapid onset of action
Rapid onset of drug action
Reduce allergy symptoms
Reduced allergy symptoms
Reduced symptoms
Reduced symptoms of allergic rhinoconjunctivitis
Reduces allergy symptoms
Safe for children
Seasonal allergic rhinoconjunctivitis treatment
Significant improvement in allergy symptoms
Symptom improvement
Symptom reduction
Treats allergic rhinitis
Treats allergic rhinoconjunctivitis
Treats allergy symptoms
Treats seasonal allergic rhinoconjunctivitis
Well tolerated
allergy symptom relief
Adverse effects
Astemizole side effects
Drug withdrawal
Loratadine side effects
Side effects
Side effects of astemizole
Side effects with astemizole
Treatment withdrawal
Withdrawal
Withdrawal due to adverse effects
Withdrawal due to side effects
Withdrawal from treatment
Withdrawal from treatment due to adverse effects
Withdrawals
astemizole side effects
loratadine side effects

Loratadine and astemizole, both antihistamines, effectively treated seasonal allergic rhinoconjunctivitis in children with similar efficacy but differing side effect profiles.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Evaluation of the efficacy and safety of loratadine in perennial allergic rhinitis.

Author: BruttmannG, CharpinD, GermoutyJ, HorakF, KunkelG, WittmannG

Allergic rhinitis relief
Allergic rhinitis treatment
Allergy symptom reduction
Allergy symptom relief
Effective
Effective allergic rhinitis treatment
Effective antihistamine
Effective for 28 days
Effective for allergic rhinitis
Effective for perennial allergic rhinitis
Effective for perennial rhinitis
Effective for rhinitis
Effective rhinitis treatment
Effective treatment
Effective treatment for rhinitis
Effective treatment of perennial allergic rhinitis
Few sedative effects
Few side effects
Good efficacy
Improved efficacy
Improved rhinitis
Loratadine efficacy
Loratadine safety
Low incidence of side effects
Low side effect
Low side effect incidence
Low side effects
Minimal dry mouth
Minimal sedation
Minimal side effects
No sedation
Non-sedating
Non-sedating antihistamine
Nonsedating
Nonsedating antihistamine
Reduce allergy symptoms
Reduced allergic rhinitis symptoms
Reduced allergic symptoms
Reduced allergy symptoms
Reduced rhinitis symptoms
Reduced symptom scores
Reduced symptoms
Reduced symptoms of allergic rhinitis
Reduces allergy symptoms
Reduces symptom scores
Reduces symptoms
Rhinitis symptom relief
Rhinitis symptoms reduced
Safe and effective
Symptom reduction
Symptom score reduction
Treats allergic rhinitis
Treats perennial allergic rhinitis
Well tolerated
allergic rhinitis treatment
allergy symptom relief
efficacy for rhinitis
Dry mouth
Few side effects
Loratadine side effects
Low incidence of side effects
Low side effect incidence
Low side effects
Mild side effects
Minor side effects
Sedation
Side effects
Side effects low
loratadine side effects
minor side effects

Loratadine, a non-sedating antihistamine, effectively reduced symptoms of perennial allergic rhinitis compared to placebo and terfenadine with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Comparative study of SCH 434 and CTM-D in the treatment of seasonal allergic rhinitis.

Author: PrevostM, TurenneY, MooteD W, MazzaJ, ClermontA, PetitClercC, DanzigM R

Allergic Rhinitis Relief
Allergic rhinitis
Allergic rhinitis relief
Allergic rhinitis symptom relief
Allergic rhinitis treatment
Allergy relief
Allergy symptom relief
Allergy treatment
Effective allergic rhinitis relief
Effective allergic rhinitis treatment
Effective allergy treatment
Effective for allergic rhinitis
Effective for allergies
Effective for allergy
Effective for rhinitis
Effective for seasonal allergic rhinitis
Effective in treating allergic rhinitis
Effective rhinitis relief
Effective rhinitis treatment
Effective treatment
Effective treatment for allergic rhinitis
Efficacy in relieving allergic rhinitis symptoms
Extended-release combination
Few side effects
Fewer Side Effects
Fewer side effects
Improved allergic rhinitis symptoms
Improved rhinitis
Improved rhinitis symptoms
Less side effects
Loratadine + pseudoephedrine
Loratadine combination
Loratadine plus pseudoephedrine sulfate
Loratadine plus pseudoephedrine sulfate efficacy
Loratadine rhinitis
Loratadine rhinitis relief
Low side effects
Lower incidence of side effects
Lower side effect incidence
Lower side effects
Non-sedating
Nonsedating
Pseudoephedrine rhinitis
Pseudoephedrine rhinitis relief
Reduce side effects
Reduced Allergic Symptoms
Reduced Side Effects
Reduced allergic rhinitis
Reduced allergic rhinitis symptoms
Reduced dry mouth
Reduced fatigue
Reduced rhinitis
Reduced rhinitis symptoms
Reduced sedation
Reduced side effects
Reduced symptoms
Reduced symptoms of allergic rhinitis
Relief of Rhinitis Symptoms
Relieve allergic rhinitis
Relieve allergic rhinitis symptoms
Relieve rhinitis symptoms
Relieved rhinitis symptoms
Relieves allergic rhinitis symptoms
Relieves allergy symptoms
Rhinitis relief
Rhinitis symptom improvement
Rhinitis symptom relief
Rhinitis treatment
Seasonal Allergic Rhinitis Treatment
Symptom relief
Treat allergic rhinitis
Treats allergic rhinitis
Treats seasonal allergic rhinitis
Well tolerated
Well-tolerated
allergic rhinitis relief
allergic rhinitis symptom relief
allergic rhinitis treatment
fewer side effects
lower side effects
reduced side effects
relieves allergy symptoms
treat allergic rhinitis
Chlorpheniramine dry mouth
Chlorpheniramine fatigue
Chlorpheniramine sedation
Dry Mouth
Dry mouth
Fatigue
Loratadine dry mouth
Loratadine fatigue
Loratadine sedation
Placebo effect
Seasonal allergic rhinitis
Sedation
Side effects
dry mouth
fatigue
sedation

The combination of loratadine plus pseudoephedrine sulfate was as effective as chlorpheniramine maleate plus pseudoephedrine sulfate in treating seasonal allergic rhinitis, but with a lower incidence of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Efficacy and safety of azelastine nasal spray for the treatment of allergic rhinitis.

Author: GoldenS J, CraigT J

Allergic rhinitis relief
Nasal congestion reduction
Drowsiness
Headache

Azelastine nasal spray is an effective treatment for allergic rhinitis. It has a rapid onset, long duration of action, and minimal systemic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Cost and utilization impacts of oral antihistamines in the California Medi-Cal program.

Author: HayJoel W, LeahyMichael

AR treatment
AR treatment efficacy
Allergic Rhinitis Treatment
Allergic rhinitis
Allergic rhinitis treatment
Effective AR treatment
Effective allergic rhinitis treatment
Effective antihistamines
Effective for allergic rhinitis
Effective treatment
Effective treatment for allergic rhinitis
Efficacy
Efficacy of SGAs
Efficacy of treatment
Improved AR treatment
Improved efficacy
Increased efficacy
Newer antihistamines
Reduced AR symptoms
Reduced SGA side effects
Reduced allergic rhinitis symptoms
Reduced side effects
Reduced side effects of SGAs
Reduced side effects of antihistamines
Reduced side-effects
Reduced side-effects of SGAs
SGA allergy treatment
SGA efficacy
SGA for AR
SGA side effect reduction
SGA side effects
SGA therapy
SGAs effective
SGAs effective and safe
SGAs effective for AR
SGAs for AR
SGAs have fewer side effects
SGAs reduce side effects
SGAs safe
SGAs well-tolerated
Second generation antihistamine efficacy
Second generation antihistamine side effect reduction
Second-generation antihistamine
Second-generation antihistamine efficacy
Second-generation antihistamine tolerability
Second-generation antihistamine treatment
Second-generation antihistamines
Second-generation antihistamines effective
Second-generation antihistamines efficacy
Second-generation antihistamines for allergic rhinitis
Second-generation antihistamines have fewer side effects
Second-generation antihistamines side-effect reduction
Treatment of allergic rhinitis
efficacy
reduced side effects
second-generation antihistamines
AR treatment cost
Allergic rhinitis
Allergic rhinitis treatment
Antihistamine use
Cost
Cost comparison needed
Cost of treatment
Costly treatment
FGA side effects
First-generation antihistamine side effects
First-generation antihistamines
Higher cost
Increased cost
None mentioned
None reported
Treatment cost

Second-generation antihistamines (SGAs) are widely preferred for allergic rhinitis due to their efficacy and fewer side effects compared to first-generation antihistamines (FGAs). However, there are no studies comparing the cost of treatment between these two types of antihistamines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.

Author: HeyJ A, del PradoM, KreutnerW, EganR W

Allergic Disorder Relief
Allergic Disorder Treatment
Allergic disorder relief
Allergic disorder treatment
Allergic disorders
Allergic disorders treatment
Allergic rhinitis treatment
Allergy relief
Allergy treatment
Antihistamine efficacy
Ebastine allergic disorder treatment
Effective allergic disorder treatment
Effective allergic rhinitis treatment
Effective allergic treatment
Effective allergy treatment
Effective for allergic disorders
Effective for allergies
Effective in treating allergic disorders
Effective treatment
Effective treatment for allergic disorders
Efficacy in treating allergic disorders
Improved allergic disorders
Less sedation
Loratadine safe
No adverse ECG effects
No sedation
No sedative effects
No sedative side effects
No significant sedation
No significant sedative side effects
Non-sedating
Non-sedating antihistamine
Non-sedating antihistamines
Nonsedating
Nonsedating antihistamine
Reduced Sedation
Reduced allergic symptoms
Reduced sedation
Reduced sedative effects
Reduced sedative side effects
Second generation antihistamine
Second generation antihistamine efficacy
Second generation antihistamines
Treat allergic disorders
Treatment of allergic disorders
Treats allergic disorders
Treats allergies
allergic disorder treatment
effective for allergic disorders
non-sedating
treat allergic disorders
Adverse drug interaction effects
Antihistamine arrhythmia
Antihistamine interaction
Arrhythmia
Arrhythmias
Arrhythmogenic activity
Astemizole arrhythmia
Astemizole torsades de pointes
Bradycardia
Cardiac Arrhythmia
Cardiac arrhythmia
Cardiac arrhythmias
Cardiotoxic
Cardiotoxic Effects
Cardiotoxic effects
Cardiotoxic proclivity
Cardiotoxic properties
Cardiotoxic side effects
Cardiotoxicity
Cardiovascular effects
Cardiovascular side effects
Drug interaction
Drug interactions
Ebastine cardiotoxic
Ebastine torsades de pointes
Hypotension
Ketoconazole drug interaction
Proarrhythmogenic activity
QTc interval prolongation
QTc prolongation
Terfenadine arrhythmia
Terfenadine cardiotoxic
Terfenadine torsades de pointes
Torsade De Pointes
Torsade de pointes
Torsades de pointes
Ventricular arrhythmia
arrhythmia
arrhythmogenic activity
bradycardia
drug interactions
hypotension
proarrhythmogenic activity
torsade de pointes

Terfenadine and ebastine, two second-generation antihistamines, exhibited similar cardiotoxic properties, characterized by QTc interval prolongation, bradycardia, hypotension, and proarrhythmogenic activity. Loratadine, however, did not show these adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

[Loratadine in the treatment of seasonal allergic rhinitis].

Author: BukoZ, SiergiejkoZ, Chyrek-BorowskaS

Allergic Rhinitis Relief
Allergic rhinitis
Allergic rhinitis relief
Allergic rhinitis symptom relief
Allergic rhinitis treatment
Allergy relief
Allergy treatment
Alleviate rhinitis symptoms
Effective
Effective allergic rhinitis relief
Effective allergic rhinitis treatment
Effective allergy treatment
Effective for allergic rhinitis
Effective for rhinitis
Effective for seasonal allergic rhinitis
Effective in treating allergic rhinitis
Effective rhinitis treatment
Effective treatment
Eosinophil reduction
Eosinophilia reduction
Few side effects
Improve allergy symptoms
Improved allergic rhinitis symptoms
Improved clinical symptoms
Improved rhinitis
Improved rhinitis symptoms
Improved symptoms
Improvement of clinical symptoms
Loratadine
Loratadine effective
Loratadine efficacy
Loratadine eosinophil
Loratadine rhinitis
Loratadine rhinitis relief
Low side effects
Lower side effects
No side effects
No significant side effects
Non-sedating
Nonsedating
Reduce eosinophilia
Reduced Allergic Rhinitis Symptoms
Reduced Allergic Symptoms
Reduced allergic rhinitis
Reduced allergic rhinitis symptoms
Reduced eosinophilia
Reduced eosinophils
Reduced nasal eosinophilia
Reduced rhinitis
Reduced rhinitis symptoms
Reduced symptoms
Reduces eosinophilia
Reduces eosinophils
Reduction of eosinophilia
Relieve allergic rhinitis
Relieves allergic rhinitis
Relieves allergic rhinitis symptoms
Relieves allergy symptoms
Relieves rhinitis symptoms
Rhinitis Symptom Relief
Rhinitis relief
Rhinitis symptom improvement
Rhinitis symptom relief
Rhinitis symptoms
Rhinitis treatment
Safe
Seasonal Allergic Rhinitis Treatment
Seasonal allergic rhinitis treatment
Seasonal rhinitis treatment
Symptom improvement
Tolerable
Treats allergic rhinitis
Treats seasonal allergic rhinitis
Well tolerated
Well-tolerated
allergic rhinitis relief
allergic rhinitis symptom relief
allergic rhinitis treatment
eosinophil reduction
low side effects
reduced eosinophilia
relieves allergy symptoms
treat allergic rhinitis
well-tolerated
Few side effects
No notable side effects
No side effects
No significant risks
No significant side effects
Placebo effect
Seasonal allergic rhinitis
Side effects

Loratadine was significantly more effective than placebo in relieving symptoms of seasonal allergic rhinitis, with 84.6% of patients showing good or very good results.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Polish

19.

Antiallergic effects of H1-receptor antagonists.

Author: BaroodyF M, NaclerioR M

Allergic Disease Treatment
Allergic disease treatment
Allergic response reduction
Allergic rhinitis treatment
Allergy treatment
Anti-allergic effects
Anti-inflammatory effects
Antiallergic effects
Antihistamine action
Antihistamine effects
Antihistamines reduce allergic response
Antihistamines treat allergic rhinitis
Block allergen-induced hyperresponsiveness
Blocked hyperresponsiveness
Eosinophil infiltration reduction
H1-antihistamine action
H1-antihistamines effective for allergic rhinitis
H1-receptor antagonism
H1-receptor antagonist benefit
Histamine release inhibition
Histamine release reduction
Improved allergic rhinitis
Improved allergy symptoms
Improved allergy treatment
Inhibition of histamine release
Inhibits LTC4 and LTB4 release
Inhibits histamine release
Mizolastine inhibits allergic inflammatory response
Mizolastine shows promise for allergic diseases
Neutrophil infiltration inhibition
Reduce allergic response
Reduce allergic symptoms
Reduce eosinophilic infiltration
Reduce histamine release
Reduced LTs
Reduced allergen-induced hyperresponsiveness
Reduced allergic inflammation
Reduced allergic response
Reduced allergic rhinitis
Reduced allergic symptoms
Reduced eosinophil infiltration
Reduced eosinophilic infiltration
Reduced histamine release
Reduced hyperresponsiveness
Reduced inflammation
Reduced leukotriene release
Reduced neutrophil infiltration
Reduced side effects
Some H1-antihistamines have additional benefits
Treat allergic diseases
Treat allergic rhinitis
Treatment of allergic rhinitis
Allergic inflammation
Anti-5-HT effects
Anticholinergic effects
Anticholinergic
sedative
local anaesthetic
and anti-5-HT effects
Antihistamine side effects
Antihistamines have side effects
Complex mechanism
Drug side effects
Local anesthetic effects
Multiple effects
Not uniformly shared
Prolonged QTc Intervals
Sedation
Sedative effects
Side Effects
Side effects
Side effects of H1-antihistamines
Side effects of antihistamines
Side effects of first-generation H1-antihistamines
Side effects of medications
Side-effects

This study reviewed the pharmacological properties of H1-antihistamines, highlighting their additional effects beyond H1-receptor antagonism. Some antihistamines inhibit IgE-mediated histamine and leukotriene release, reduce eosinophilic infiltration, and block allergen-induced hyperresponsiveness. The study suggests that these additional properties may contribute to their antiallergic effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition.

Author: NamaziM R

Allopurinol
Allopurinol antipsoriatic effect
Allopurinol downregulates P2X7 receptors
Allopurinol effective
Allopurinol effective against psoriasis
Allopurinol effective for psoriasis
Allopurinol efficacy
Allopurinol for psoriasis
Allopurinol for psoriasis treatment
Allopurinol inhibits TNF-alpha production
Allopurinol may treat psoriasis
Allopurinol potential treatment for psoriasis
Allopurinol psoriasis
Allopurinol psoriasis treatment
Allopurinol scavenges free radicals
Allopurinol therapy
Allopurinol treatment
Anti-inflammatory effects
Anti-psoriatic effect
Antipsoriatic treatment
Cannabinoid antipsoriatic effect
Cannabinoid efficacy
Cannabinoid psoriasis treatment
Cannabinoid therapy
Cannabinoid treatment
Cannabinoids
Cannabinoids effective
Cannabinoids effective against psoriasis
Cannabinoids effective for psoriasis
Cannabinoids efficacy
Cannabinoids for psoriasis
Cannabinoids for psoriasis treatment
Cannabinoids inhibit IL-2 release
Cannabinoids inhibit TNF-alpha release
Cannabinoids inhibit nitric oxide release
Cannabinoids may treat psoriasis
Cannabinoids potential treatment for psoriasis
Cannabinoids psoriasis
Cannabinoids psoriasis treatment
Cannabinoids treatment
Cannabinoids
loratadine
and allopurinol may be effective for psoriasis
Downregulation of P2X7 receptors
Downregulation of inflammatory response
Downregulation of intercellular adhesion molecule-1
Free radical scavenging
Improved cAMP/cGMP ratio
Improved immune response
Improved inflammation
Improved psoriasis
Improved psoriasis outcomes
Improved psoriasis treatment
Increase cAMP/cGMP ratio
Increased cAMP/cGMP ratio
Inhibit antigen processing
Inhibit macrophage/T-cell interaction
Inhibition of IL-2 release
Inhibition of TNF-alpha
Inhibition of TNF-alpha production
Inhibition of TNF-alpha release
Inhibition of antigen processing
Inhibition of immune response
Inhibition of inflammatory response
Inhibition of macrophage/T-cell interaction
Inhibition of nitric oxide release
Inhibitory effects
Inhibitory effects on IL-2
TNF-alpha
Loratadine
Loratadine antipsoriatic effect
Loratadine effective
Loratadine effective against psoriasis
Loratadine effective for psoriasis
Loratadine efficacy
Loratadine for psoriasis
Loratadine for psoriasis treatment
Loratadine increases cAMP/cGMP ratio
Loratadine may treat psoriasis
Loratadine potential treatment for psoriasis
Loratadine psoriasis
Loratadine psoriasis treatment
Loratadine therapy
Loratadine treatment
Potential new treatments for psoriasis
Potential psoriasis treatment
Potential psoriasis treatments
Potential treatment
Potential treatment for psoriasis
Potential treatments
Potential treatments for psoriasis
Production of leukotriene B4
Psoriasis
Psoriasis Treatment
Psoriasis treatment
Reduce IL-2
Reduce TNF-alpha
Reduce leukotriene B4
Reduce nitric oxide
Reduce psoriasis symptoms
Reduced IL-2 production
Reduced IL-2 release
Reduced TNF-alpha production
Reduced TNF-alpha release
Reduced histamine release
Reduced immune response
Reduced inflammation
Reduced nitric oxide production
Reduced nitric oxide release
Reduced psoriasis
Reduced psoriasis severity
Reduced side effects
Reduces inflammation
Safer agents
Safer antipsoriatic
Safer antipsoriatic agents
Safer antipsoriatic treatment
Safer psoriasis treatment
Safer psoriasis treatments
Safer treatment
Safer treatment option
Safer treatment options for psoriasis
Scavenge free radicals
TNF-alpha inhibition
Treatment of psoriasis
Treats psoriasis
allopurinol treatment
cannabinoid treatment
loratadine treatment
potential treatments for psoriasis
safer agents
safer antipsoriatic agents
Antipsoriatic drug side effects
Antipsoriatic drug side-effects
Antipsoriatic medication side effects
Antipsoriatic medication side-effects
Antipsoriatic side effects
Antipsoriatic side-effects
Deleterious side-effects
None reported
Psoriasis
Psoriasis side effects
Psoriasis treatment
Side Effects
Side effects
Side effects of antipsoriatic medications
Side effects of current medications
Side-effects
Side-effects of antipsoriatic medications

Three potential treatments for psoriasis are presented: cannabinoids, loratadine, and allopurinol. Cannabinoids inhibit cytokine release and immune cell interactions, loratadine increases cAMP/cGMP ratio, and allopurinol scavenges free radicals and inhibits TNF-alpha production. These agents could be used alone or in combination with current antipsoriatic drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

[Drug-induced toxidermia in a patient receiving hydroxychloroquine as systemic therapy for primary Gougerot-Sjögren syndrome: a case report].

Author: KeitaAnsumana Mohammed, ZahlaneMouna, BenjilaliLaila, EssaadouniLamiaa

This case report highlights the importance of cautious hydroxychloroquine prescribing for patients with a history of kidney disease. The patient developed a maculopapular rash after starting hydroxychloroquine, which resolved after the medication was stopped. The report underscores the need for patient education about potential side effects of hydroxychloroquine.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : French

22.

Loratadine versus cetirizine: assessment of somnolence and motivation during the workday.

Author: SalmunL M, GatesD, ScharfM, GreidingL, RamonF, HeithoffK

Increased motivation
Reduced somnolence

Cetirizine promotes somnolence and decreases motivation to perform activities during the workday compared with loratadine in patients with allergic rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.

Author: GashevaOlga Y, Tsoy NizamutdinovaIrina, HargroveLaura, GobbellCassidy, Troyanova-WoodMaria, AlpiniSally F, PalSarit, DuChristina, HittAngie R, YakovlevVlad V, Newell-RogersM Karen, ZawiejaDavid C, MeiningerCynthia J, AlpiniGianfranco D, FrancisHeather, GashevAnatoliy A

Metabolic syndrome
Obesity

Prolonged intake of desloratadine, a common antihistamine, induced obesity and metabolic syndrome in rats. These effects were linked to dysfunction of mesenteric lymphatic vessels, suggesting that antihistamines may have underevaluated lymphatic-related side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

24.

Efficacy of intranasal steroid spray (mometasone furoate) on treatment of patients with seasonal allergic rhinitis: comparison with oral corticosteroids.

Author: KarakiMasayuki, AkiyamaKosuke, MoriNozomu

Allergic rhinitis relief
Nasal symptom management
Side effects
Topical corticosteroid use

Intranasal corticosteroids and systemic oral corticosteroids are both effective treatments for allergic rhinitis. This study compared the efficacy of mometasone furoate nasal spray (MFNS) and betamethasone oral tablets (BOT) in patients with seasonal allergic rhinitis. Results showed that both treatments were effective in managing nasal symptoms, but MFNS was more commonly preferred due to fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Steroid and antihistamines modulate RANTES release in cultured peripheral blood mononuclear cells of atopic patients.

Author: Di GioacchinoM., VernaN., CavallucciE., PaoliniF., CarusoR., GranaM., SchiavoneC., Di IorioA., RamondoS., RealeM., PaganelliR., TheoharidesT. C.

Allergic Inflammation Control
Allergic inflammation
Allergic inflammation control
Allergic inflammation reduction
Allergic inflammation treatment
Allergy treatment
Antihistamine benefit
Antihistamines may prevent allergic inflammation
Antihistamines reduce allergic inflammation
Antihistamines reduce cell recruitment
Asthma control
Asthma improvement
Asthma symptom improvement
Asthma symptom relief
Asthma treatment
Cell recruitment reduction
Control allergic inflammation
Control asthma
Controlled allergic inflammation
Improve asthma symptoms
Improved PEF
Improved asthma
Improved asthma control
Improved asthma symptoms
Improved breathing
Improved lung function
Improved peak expiratory flow
RANTES modulation
RANTES reduction
RANTES release reduction
Reduce RANTES release
Reduce allergic inflammation
Reduce cell recruitment
Reduced RANTES release
Reduced allergic inflammation
Reduced asthma symptoms
Reduced cell recruitment
Reduced inflammation
Steroid treatment reduces RANTES release
Steroids and antihistamines reduce RANTES release
Allergic inflammation
Antihistamine side effects
Antihistamines less effective than steroids
Chemokine release
Drug side effects
None mentioned
RANTES
RANTES release reduction
Side Effects
Side effects
Side effects of antihistamines
Side effects of medications
Side effects of steroid
Side effects of steroid treatment
Side effects of steroids
Side-effects
Steroid benefit
Steroid effectiveness
Steroid side effects

This study found that steroid treatment was the most effective in reducing the release of RANTES, a chemokine that plays a crucial role in allergic inflammation. Antihistamines were also effective in reducing RANTES release, but to a lesser extent. Steroids improved peak expiratory flow (PEF) values and diurnal variability more significantly than antihistamines or placebo. The study suggests that antihistamines may be useful in long-term therapy to control and prevent allergic inflammation, while steroids provide a more immediate and effective solution.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

[New generation antihistamines as monotherapy or in combination. What is the relevance for daily clinical routine for allergic rhinoconjunctivitis].

Author: MösgesR, KöberleinJ

Allergic Rhinitis Treatment
Allergic rhinitis
Allergic rhinitis relief
Allergic rhinitis treatment
Clinical efficacy
Ebastine
Ebastine efficacy
Ebastine improved efficacy
Ebastine non-sedating
Ebastine non-sedating antihistamine
Effective Allergy Treatment
Effective allergic rhinitis treatment
Effective for allergic rhinitis
Effective rhinitis treatment
Effective treatment of allergic rhinitis
Improved Allergic Rhinitis
Improved allergic rhinitis
Improved allergic rhinitis symptoms
Improved allergic rhinitis treatment
Improved clinical efficacy
Improved efficacy
Improved rhinitis
Improved rhinitis treatment
Increased dosage
Non-Sedating
Non-sedating
Non-sedating antihistamine
Reduced allergic rhinitis
Reduced allergy symptoms
Reduced drowsiness
Reduced side effects
Rhinitis relief
Treatment of allergic rhinitis
Treats allergic rhinitis
Antihistamine drowsiness
Antihistamine drowsiness risk
Antihistamine side effects
Drowsiness
Drowsiness (High Dose)
Drowsiness (antihistamines)
Drowsiness (cetirizine
loratadine)
Drowsiness (with other antihistamines)
Increased dose
Side effects

The study discusses the use of ebastine, a non-sedating antihistamine, for the treatment of severe allergic rhinitis. While current guidelines recommend a combination of oral antihistamines and nasal steroids, many patients prefer antihistamine monotherapy. Ebastine, at a higher dose of 20 mg daily, has demonstrated improved clinical efficacy compared to the standard dose of 10 mg daily, without an increased risk of side effects.

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

27.

A comparison of new nonsedating and classical antihistamines in the treatment of primary acquired cold urticaria (ACU).

Author: Villas MartínezF, ContrerasF J, López CazañaJ M, López SerranoM C, Martínez AlzamoraF

ACU symptom relief
ACU symptom suppression
ACU treatment
ACU treatment efficacy
Allergy symptom reduction
Allergy symptom relief
Antihistamine efficacy
CSTT improved
CSTT improvement
Cetirizine efficacy
Cold urticaria relief
Cold urticaria treatment
Effective
Effective ACU treatment
Effective antihistamine
Effective cold urticaria treatment
Effective for ACU
Effective for acquired cold urticaria
Effective for cold urticaria
Effective for primary ACU
Effective for primary acquired cold urticaria
Effective treatment
Effective treatment for ACU
Effective treatment of ACU
Few adverse effects
Few side effects
Histamine inhibition
Histamine-induced wheal inhibition
Histamine-induced wheal response inhibited
Improved ACU symptoms
Improved CSTT
Improved cold contact stimulation time
Improved cold tolerance
Improved cold urticaria
Infrequent adverse effects
Inhibited histamine response
Inhibited histamine-induced wheal response
Inhibition of histamine-induced wheal
Inhibition of histamine-induced wheal response
Inhibition of wheal response
Inhibits histamine
Inhibits histamine-induced wheal response
Inhibits wheal response
Loratadine efficacy
Minimal side effects
Non-sedating
Nonsedating
Reduced ACU symptoms
Reduced CSTT
Reduced allergy symptoms
Reduced cold contact stimulation time
Reduced cold urticaria symptoms
Reduced symptoms
Reduced symptoms of cold urticaria
Reduced wheal response
Reduces allergy symptoms
Reduces symptoms
Suppressed ACU symptoms
Suppressed symptoms
Suppresses symptoms
Suppression of ACU symptoms
Suppression of symptoms
Symptom suppression
Symptoms suppressed
Treat cold urticaria
Treats ACU
Treats acquired cold urticaria
Treats cold urticaria
Treats primary ACU
Treats primary acquired cold urticaria
Well tolerated
histamine inhibition
Cyproheptadine side effects
Dry mouth
Infrequent adverse effects
Sedation
Sedation (infrequent)
Side effects
Side effects from cyproheptadine
Side effects infrequent
Side effects of cyproheptadine
Side effects with classical antihistamines
Side effects with cyproheptadine
cetirizine side effects
cyproheptadine side effects

Loratadine and cetirizine, non-sedating antihistamines, effectively treated primary acquired cold urticaria, while cyproheptadine had significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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