Paper Details

  1. Home
  2. Paper Details

Efficacy of standard and low dose hydrochlorothiazide in the recurrence prevention of calcium nephrolithiasis (NOSTONE trial): protocol for a randomized double-blind placebo-controlled trial.

Author: AmicoPatrizia, BedinoGiulia, BonnyOlivier, BuchkremerFlorian, Del GiornoRosaria, DhayatNasser A, ErnandezThomas, FallerNicolas, FusterDaniel G, GabuttiLuca, HüslerCarina, IrincheevaIrina, KonethIrene, MayrMichael, MohebbiNilufar, OdermattUrs, PellegriniLisa, RintelenFelix, RitterAlexander, RothBeat, RoumetMarie, SchönholzerCarlo, Stoermann-ChopardCatherine, TamòLuca, TetaDaniel, TrelleSven, VenzinReto M, VogtBruno

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Kidney stones are a common problem, with a high risk of developing them over a lifetime. While treatment for kidney stones is costly and can cause problems, preventing them with medication is a desirable option. Thiazide diuretics have been used for decades to prevent kidney stones, but there is still uncertainty about their benefits and potential harms. Additionally, it is unclear if the low doses of thiazide used currently are effective in preventing kidney stones from returning.
Paper Details　
Original Abstract of the Article :
Nephrolithiasis is a global healthcare problem with a current lifetime risk of 18.8% in men and 9.4% in women. Given the high cost of medical treatments and surgical interventions as well as the morbidity related to symptomatic stone disease, medical prophylaxis for stone recurrence is an attractive...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288917/

データ提供：米国国立医学図書館（NLM）

Hydrochlorothiazide for Calcium Nephrolithiasis: A Randomized Trial

The journey of kidney stone formation is a complex and often painful one, like navigating a desert filled with treacherous terrain. This study investigates the effectiveness of hydrochlorothiazide, a thiazide diuretic, in preventing the recurrence of calcium nephrolithiasis. The researchers designed a randomized, double-blind, placebo-controlled trial to assess the efficacy of hydrochlorothiazide, seeking to find the most effective solution to prevent this common condition.

Exploring the Efficacy of Hydrochlorothiazide in Stone Prevention

The study aimed to compare the efficacy of standard and low-dose hydrochlorothiazide with placebo in preventing the recurrence of calcium nephrolithiasis. The researchers sought to address the lack of definitive evidence regarding the benefits and harms of thiazides in stone prevention and to assess the efficacy of low-dose regimens. It's like conducting a comprehensive exploration of a vast desert, seeking to identify the most effective strategies to prevent the formation of sandstorms.

Addressing the Global Burden of Nephrolithiasis

The study's findings could significantly impact the management of nephrolithiasis, a global healthcare problem affecting millions of people. The research aims to provide evidence-based recommendations for the use of hydrochlorothiazide in preventing stone recurrence, potentially reducing the burden of this condition on patients and healthcare systems. This is like developing a network of oases across the desert, providing a sustainable and effective solution for preventing dehydration.

Dr.Camel's Conclusion

This study emphasizes the importance of evidence-based medicine in addressing complex health issues such as nephrolithiasis. The research will contribute to a deeper understanding of hydrochlorothiazide's efficacy and safety in preventing stone recurrence, providing valuable insights for clinicians and patients alike.

Date :
  1. Date Completed 2019-10-03
  2. Date Revised 2019-10-07
Further Info :

Pubmed ID

30526528

DOI: Digital Object Identifier

PMC6288917

Related Literature

Article Analysis
・Effective treatment of kidney stones
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.