Analysis of comprehensive pharmacogenomic profiling to impact in-hospital prescribing.

Author: DanaheyKeith, KnoebelRandall W, LeeYee Ming, MeltzerDavid O, O'DonnellPeter H, RatainMark J

Paper Details 
Original Abstract of the Article :
INTRODUCTION: In-hospital adverse medication events result in increased morbidity and mortality. Many implicated drugs carry pharmacogenomic information. We hypothesized that comprehensive pre-emptive pharmacogenomic profiling could have high relevance for in-hospital prescribing. PATIENTS AND METH...See full text at original site
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引用元:
https://doi.org/10.1097/FPC.0000000000000346

データ提供:米国国立医学図書館(NLM)

Pharmacogenomic Profiling to Optimize In-Hospital Prescribing

This study delves into the exciting world of pharmacogenomics, exploring how genetic information can be used to personalize medication therapy and improve patient safety. The authors investigate the potential of comprehensive pharmacogenomic profiling to impact in-hospital prescribing. They analyzed medication changes in a genotyped outpatient cohort admitted to the hospital, focusing on drugs with known pharmacogenomic annotations. The study found that a significant portion of hospitalized patients received medications with pharmacogenomic implications. The authors advocate for pre-emptive genotyping of high-risk patients, especially those with polypharmacy, to inform inpatient prescribing and potentially reduce adverse drug events.

Pre-Emptive Genotyping for Safer In-Hospital Prescribing

This study highlights the importance of pharmacogenomic information in optimizing medication use, particularly in hospitalized patients. By targeting high-risk patients for pre-emptive genotyping, healthcare professionals can obtain valuable information to personalize medication therapy, potentially leading to safer and more effective treatment.

Health Implications and Life Applications

The use of pharmacogenomics has the potential to transform healthcare by enabling more personalized and effective medication therapy. Pre-emptive genotyping can help healthcare professionals anticipate potential drug-related issues and make informed decisions to optimize patient safety and therapeutic outcomes.

Dr. Camel's Conclusion

This research is like finding a hidden oasis of personalized medicine in the vast desert of healthcare. By using pharmacogenomics, we can tailor treatment plans to individual needs, like choosing the perfect watering hole for each species of camel. This approach can lead to improved patient outcomes and a more efficient use of resources.

Date :
  1. Date Completed 2020-02-20
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

30531378

DOI: Digital Object Identifier

10.1097/FPC.0000000000000346

Related Literature

SNS
PICO Info
in preparation
Languages

English

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