Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells.

Author: CaiJiali, HuRonghui, KongQingxin, LiXiaoli, LongLiangyuan, WangNing, YaoXintong, ZhouDuanfang, ZhouWeiying, ZhuGuangbei

Paper Details 
Original Abstract of the Article :
Label="BACKGROUND" NlmCategory="BACKGROUND">Celastrol is a major active component of the thunder god vine (<i>Tripterygium wilfordii</i>) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K-Akt-mTOR signaling, which is frequently dysreg...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294079/

データ提供:米国国立医学図書館(NLM)

Targeting Cancer's Achilles' Heel: Celastrol's Impact on mTOR Signaling

Breast cancer, a leading cause of cancer-related deaths, often involves dysregulation of the mTOR signaling pathway, a critical regulator of cell growth and survival. This research investigates the potential of celastrol, a natural compound derived from the thunder god vine, to inhibit mTOR signaling and suppress breast cancer cell growth. The study focused on the mechanisms by which celastrol exerts its anti-cancer effects, analyzing its impact on mTOR degradation and other key signaling pathways.

A New Frontier in Cancer Treatment: Celastrol's Potential

The study's findings suggest that celastrol has a promising role in breast cancer treatment. The researchers observed that celastrol induces the degradation of mTOR, effectively disrupting the mTOR signaling pathway and inhibiting breast cancer cell growth. This suggests that celastrol may be a valuable therapeutic agent for combating breast cancer and other cancers that involve mTOR dysregulation.

Harnessing Nature's Power: Seeking Natural Therapies for Cancer

The study's findings highlight the potential of natural compounds to provide new and innovative therapies for cancer. The research encourages further investigation into the therapeutic properties of celastrol and other natural compounds, seeking to harness nature's power to fight cancer.

Dr.Camel's Conclusion

Imagine a vast desert, where a hidden oasis provides life-giving water. This research explores celastrol as a potential oasis in the fight against breast cancer. By targeting the mTOR signaling pathway, celastrol offers a promising approach to combatting cancer cells and improving outcomes for patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

30588010

DOI: Digital Object Identifier

PMC6294079

Related Literature

SNS
PICO Info
in preparation
Languages

English

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