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Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells.
Author: CaiJiali, HuRonghui, KongQingxin, LiXiaoli, LongLiangyuan, WangNing, YaoXintong, ZhouDuanfang, ZhouWeiying, ZhuGuangbei
Original Abstract of the Article :
Label="BACKGROUND" NlmCategory="BACKGROUND">Celastrol is a major active component of the thunder god vine (<i>Tripterygium wilfordii</i>) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K-Akt-mTOR signaling, which is frequently dysreg...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294079/
データ提供:米国国立医学図書館(NLM)
Targeting Cancer's Achilles' Heel: Celastrol's Impact on mTOR Signaling
Breast cancer, a leading cause of cancer-related deaths, often involves dysregulation of the mTOR signaling pathway, a critical regulator of cell growth and survival. This research investigates the potential of celastrol, a natural compound derived from the thunder god vine, to inhibit mTOR signaling and suppress breast cancer cell growth. The study focused on the mechanisms by which celastrol exerts its anti-cancer effects, analyzing its impact on mTOR degradation and other key signaling pathways.
A New Frontier in Cancer Treatment: Celastrol's Potential
The study's findings suggest that celastrol has a promising role in breast cancer treatment. The researchers observed that celastrol induces the degradation of mTOR, effectively disrupting the mTOR signaling pathway and inhibiting breast cancer cell growth. This suggests that celastrol may be a valuable therapeutic agent for combating breast cancer and other cancers that involve mTOR dysregulation.
Harnessing Nature's Power: Seeking Natural Therapies for Cancer
The study's findings highlight the potential of natural compounds to provide new and innovative therapies for cancer. The research encourages further investigation into the therapeutic properties of celastrol and other natural compounds, seeking to harness nature's power to fight cancer.
Dr.Camel's Conclusion
Imagine a vast desert, where a hidden oasis provides life-giving water. This research explores celastrol as a potential oasis in the fight against breast cancer. By targeting the mTOR signaling pathway, celastrol offers a promising approach to combatting cancer cells and improving outcomes for patients.
Date :
- Date Completed n.d.
- Date Revised 2022-03-30
Further Info :
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