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Management of Excessive Daytime Sleepiness in Narcolepsy With Baclofen.

Author: Kelly-PieperKristin, KothareSanjeev V, MorseAnne M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Narcolepsy is a disabling sleep-wake disorder with no cure. Treatment focuses on symptom management, primarily addressing excessive daytime sleepiness, sleep fragmentation, and cataplexy. While first-line treatments like modafinil, armodafinil, methylphenidate, amphetamines, and sodium oxybate are available, some patients experience limited efficacy, poor tolerability, or side effects.
Paper Details　
Original Abstract of the Article :
Narcolepsy is a disabling sleep-wake disorder characterized by the pentad symptoms of excessive daytime sleepiness, sleep paralysis, sleep fragmentation, sleep-related hallucinations, and cataplexy. There is no curative therapy for narcolepsy. Treatment is therefore symptom directed. Symptom managem...See full text at original site
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引用元：
https://doi.org/10.1016/j.pediatrneurol.2018.10.020

データ提供：米国国立医学図書館（NLM）

Managing Excessive Daytime Sleepiness in Narcolepsy: Exploring New Treatment Options

Narcolepsy, a debilitating sleep disorder, significantly impacts a person's daily life. This review explores the management of excessive daytime sleepiness (EDS), a hallmark symptom of narcolepsy, and delves into the use of baclofen as a potential treatment option. The authors discuss the limitations of traditional treatments, such as wake-promoting agents and stimulant therapies, and examine baclofen's potential benefits in addressing EDS in narcolepsy.

Baclofen: A Potential New Avenue for Managing Excessive Daytime Sleepiness in Narcolepsy

The review suggests that baclofen, a medication typically used for muscle spasms, may hold potential for managing EDS in narcolepsy. While baclofen has shown some promising results in reducing EDS, more research is needed to establish its efficacy and safety in this context. The authors highlight the need for well-designed clinical trials to further explore baclofen's potential for treating EDS in narcolepsy.

Finding the Right Path: Managing EDS in Narcolepsy

This review highlights the ongoing search for effective treatments for narcolepsy. It's like a caravan traversing a vast desert, seeking relief from the debilitating effects of this sleep disorder. Baclofen offers a potential new avenue for addressing EDS, but further research is crucial to determine its efficacy and safety. This research underscores the importance of ongoing exploration and innovation in the pursuit of effective treatments for narcolepsy.

Dr.Camel's Conclusion

This research explores a potential new oasis in the desert of narcolepsy treatment. Baclofen, a medication known for its muscle-relaxing properties, may also offer relief from EDS in narcolepsy. However, more research is needed to confirm its efficacy and safety. This research reminds us that the pursuit of effective treatments for complex conditions requires ongoing exploration and innovation, seeking new paths to alleviate suffering and improve patient well-being.

Date :
  1. Date Completed 2020-04-22
  2. Date Revised 2020-04-22
Further Info :

Pubmed ID

30595352

DOI: Digital Object Identifier

10.1016/j.pediatrneurol.2018.10.020

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