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Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods.

Author: CorradiniLaura, KuoAndy, NicholsonJanet R, SmithMaree T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study established a rat model of antiretroviral toxic neuropathy (ATN) induced by stavudine (d4T). The model exhibited sustained mechanical allodynia and showed dose-dependent relief with gabapentin and morphine. This model can be used to investigate the pathophysiology of d4T-induced sensory neuropathy and for profiling novel analgesic drugs.
Paper Details　
Original Abstract of the Article :
Human immuno-deficiency virus (HIV) associated sensory neuropathy (SN) is a frequent complication of HIV infection. It is extremely difficult to alleviate and hence the quality of life of affected individuals is severely and adversely impacted. Stavudine (d4T) is an antiretroviral drug that was wide...See full text at original site
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引用元：
https://doi.org/10.1007/s10787-018-00551-8

データ提供：米国国立医学図書館（NLM）

Stavudine-Induced Neuropathy: A Desert of Pain

This research explores the development and characterization of a rat model of antiretroviral toxic neuropathy (ATN) induced by stavudine (d4T). Think of ATN as a painful desert storm that disrupts the nervous system, causing debilitating pain and discomfort. This study investigates how d4T, a drug used to treat HIV, can lead to nerve damage and pain in rats, providing insights into the mechanisms of ATN and potential therapeutic targets.

Navigating the Desert of Nerve Pain

The study shows that d4T treatment in rats leads to persistent pain and sensitivity, mimicking the symptoms experienced by patients with ATN. This model provides a valuable tool for researchers to understand the underlying mechanisms of d4T-induced neuropathy and explore potential treatments. It's like creating a miniature desert environment to study the impact of a specific storm, allowing scientists to better understand the factors that contribute to the damage and devise strategies to protect against it.

Seeking Relief in the Desert

This research provides hope for individuals suffering from ATN. By understanding the mechanisms of d4T-induced neuropathy, researchers can develop more effective therapies to alleviate pain and improve quality of life for those affected by this debilitating condition. It's like searching for a hidden oasis in the desert, seeking a refuge from the harsh realities of nerve pain.

Dr.Camel's Conclusion

This research sheds light on the challenging effects of stavudine on the nervous system. It's like discovering a hidden storm in a seemingly peaceful desert oasis, prompting us to seek ways to mitigate the damage. This study offers valuable insights into the mechanisms of ATN and provides a foundation for developing effective therapies to alleviate pain and improve the lives of those affected by this debilitating condition.
Date :
  1. Date Completed 2019-08-26
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

30600474

DOI: Digital Object Identifier

10.1007/s10787-018-00551-8

Related Literature

Article Analysis
・Effects of d4t
SNS
PICO Info
in preparation
Languages

English

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