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Exploration of germline variants responsible for adverse events of crizotinib in anaplastic lymphoma kinase-positive non-small cell lung cancer by target-gene panel sequencing.

Author: DagaHaruko, FujisakaYasuhito, FujiwaraYasuhiro, FujiwaraYutaka, FukuiTomoya, HamadaAkinobu, HoriikeAtsushi, HosodaFumie, HottaTakamasa, KogureYoshihito, MizugakiHidenori, NakamuraHiromi, NakamuraYukiko, OheYuichiro, OizumiSatoshi, OkumaYusuke, SaekiSho, SatoMitsuo, ShibataTatsuhiro, ShukuyaTakehito, UmemuraShigeki, UrataYoshiko, YamadaKazuhiko, YoshidaTatsuya

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the relationship between clinically significant crizotinib-associated adverse events and germline variations in patients with ALK- or ROS1-fusion-gene-positive non-small cell lung cancer.
Paper Details　
Original Abstract of the Article :
Crizotinib is a standard treatment for advanced anaplastic lymphoma kinase (ALK)- or ROS1-fusion-gene-positive non-small cell lung cancer; however, serious adverse events (AEs), including elevated alanine aminotransferase (ALT)/aspartate aminotransferase (AST) and interstitial lung disease (ILD), de...See full text at original site
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引用元：
https://doi.org/10.1016/j.lungcan.2018.12.002

データ提供：米国国立医学図書館（NLM）

Unraveling the Genetic Roots of Crizotinib's Side Effects

The field of cancer treatment is a vast and complex desert, with researchers constantly seeking new pathways to conquer this formidable foe. Crizotinib, a promising drug for advanced non-small cell lung cancer, offers a glimmer of hope. However, like a hidden oasis with unexpected dangers, crizotinib can sometimes cause serious side effects. This study aims to identify potential genetic factors that may contribute to these adverse events.

Mapping the Genetic Landscape of Side Effects

The researchers, like meticulous explorers charting unknown territory, investigated the connection between germline variants and clinically significant crizotinib-associated adverse events. Their findings, like a well-worn trail leading to a hidden spring, suggest potential links between genetic variations and the development of side effects. This research highlights the importance of considering individual genetic profiles when prescribing crizotinib.

Navigating the Desert of Personalized Medicine

The study underscores the growing importance of personalized medicine, an approach that considers individual genetic variations to tailor treatments. This research, like a compass guiding us through the desert of personalized medicine, provides valuable insights into the genetic factors that may influence drug response and adverse events. Further research in this area is crucial for improving the safety and efficacy of cancer treatments.

Dr. Camel's Conclusion

This research, like a camel caravan traversing a vast and complex desert landscape, sheds light on the genetic factors that may contribute to crizotinib's side effects. The study emphasizes the importance of personalized medicine in cancer treatment, where understanding individual genetic profiles can help optimize therapy and minimize adverse events.

Date :
  1. Date Completed 2019-12-20
  2. Date Revised 2019-12-20
Further Info :

Pubmed ID

30642448

DOI: Digital Object Identifier

10.1016/j.lungcan.2018.12.002

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・Side Effects of crizotinib
SNS
PICO Info
in preparation
Languages

English

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