The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia.

Author: BrooksSander, DrevetsWayne, JacobsGabriël E, KentJustine M, KezicIva, LuthringerRemy, Van NuetenLuc, ZuikerRob, de BoerPeter, van AmerongenGuido, van GervenJoop Ma, van der ArkPeter

Paper Details 
Original Abstract of the Article :
Insomnia is common in patients with major depressive disorder. Although antidepressants improve mood, insomnia often persists as a result of physiological hyperarousal. The orexin-2 receptor is increasingly being recognized as a new target for the treatment of persistent insomnia in major depressive...See full text at original site
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引用元:
https://doi.org/10.1177/0269881118822258

データ提供:米国国立医学図書館(NLM)

Seltorexant: A New Oasis in the Desert of Insomnia

Insomnia, a common and often debilitating condition, can significantly impact mental and physical well-being. Imagine insomnia as a restless desert night, where sleep eludes you, leaving you feeling exhausted and drained. This research explores the potential of seltorexant, an orexin-2 receptor antagonist, as a novel treatment for insomnia in patients with major depressive disorder.

Seltorexant: A Promising Solution for Persistent Insomnia

The research suggests that seltorexant, like a soothing desert breeze, may offer relief from persistent insomnia in patients with major depressive disorder. The authors highlight the role of the orexin-2 receptor in regulating sleep-wake cycles, suggesting that targeting this receptor could provide a new avenue for treating insomnia. The study's findings provide preliminary evidence for the potential efficacy of seltorexant in improving sleep quality in this specific population.

Navigating the Landscape of Insomnia Treatment

This research provides valuable insights into the potential of seltorexant for treating insomnia in patients with major depressive disorder. It's like finding a hidden spring in the desert, offering a new source of relief for those struggling with sleep disturbances. Further research is needed to confirm these findings and explore the long-term safety and efficacy of seltorexant in this population.

Dr.Camel's Conclusion

This research explores a novel approach to treating insomnia in patients with major depressive disorder. Like a skilled desert guide, researchers are seeking new pathways to alleviate the suffering caused by insomnia, offering hope for a future where sleep becomes a restorative refuge for those in need.

Date :
  1. Date Completed 2020-05-22
  2. Date Revised 2020-05-22
Further Info :

Pubmed ID

30644312

DOI: Digital Object Identifier

10.1177/0269881118822258

Related Literature

SNS
PICO Info
in preparation
Languages

English

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