Effective treatment of insomnia: A Synthesis of Findings from 145 Studies

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Original Abstract of the Article

Major research findings

Cognitive behavioral therapy for insomnia (CBT-I) is an effective treatment for insomnia, and its effects last longer than those of drug therapy. 14 . CBT-I works by improving sleep habits and thoughts, which reduces insomnia symptoms. 3 . CBT-I is also effective even when combined with mental health conditions such as depression or anxiety. 72 . Drug therapy can be effective in the short term, but there are concerns about tolerance and dependence. 34 .

Internet-based CBT-I can be as effective as in-person CBT-I. 76 . Internet-based CBT-I is accessible to more people because it can be used anytime, anywhere. 86 .

Acupuncture is also a promising treatment for insomnia. 67 . Acupuncture is thought to balance the body's energy flow, which improves insomnia symptoms. 46 .

Treatment Summary

Cognitive behavioral therapy (CBT-I), drug therapy, internet-based CBT-I, and acupuncture are treatments for insomnia.

CBT-I improves sleep habits and thoughts to reduce insomnia symptoms. 3 . CBT-I is also effective even when combined with mental health conditions such as depression or anxiety. 72 .

Drug therapy is effective in the short term, but there are concerns about tolerance and dependence. 34 .

Internet-based CBT-I is accessible to more people because it can be used anytime, anywhere. 86 .

Acupuncture is thought to balance the body's energy flow, which improves insomnia symptoms. 46 .

Benefits and Risks

Benefit Summary

Cognitive behavioral therapy for insomnia (CBT-I) is an effective treatment for insomnia, and its effects last longer than those of drug therapy. 14 . CBT-I works by improving sleep habits and thoughts, which reduces insomnia symptoms. 3 . CBT-I is also effective even when combined with mental health conditions such as depression or anxiety. 72 .

Internet-based CBT-I can be as effective as in-person CBT-I. 76 . Internet-based CBT-I is accessible to more people because it can be used anytime, anywhere. 86 .

Risk Summary

Drug therapy is effective in the short term, but there are concerns about tolerance and dependence. 34 .

Comparison of Research

Commonalities in Research

Many studies have shown that cognitive behavioral therapy (CBT-I) is effective for treating insomnia. 3 72 76 86 . Internet-based CBT-I has also been shown to be effective. 76 86 .

Differences in Research

There are some differences in CBT-I effectiveness and treatment methods across studies. For example, the content, duration, and target population of CBT-I may vary. The effectiveness and side effects of drug therapy also vary from study to study. 34 96 . Therefore, it is important to choose the right treatment based on your individual situation, rather than just taking the results of the research at face value.

Consistency and Contradictions in Results

Many studies have shown that cognitive behavioral therapy (CBT-I) is effective for treating insomnia, but some studies have also reported that drug therapy is more effective. 34 . This may be due to differences in study design, target population, treatment methods, etc. Therefore, it is important to choose the right treatment based on your individual situation, rather than just taking the results of the research at face value.

Notes on Applying Results to Real Life

Cognitive behavioral therapy (CBT-I) is effective in treating insomnia, but it requires effort and time. 15 . CBT-I effectiveness varies from person to person. If you don't see results, consult a doctor or specialist. Don't give up.

Limitations of Current Research

There are still many unanswered questions about insomnia research. For example, few long-term studies have evaluated the effectiveness of CBT-I, and it is unclear how long the effects of CBT-I last. 79 . The causes and mechanisms of insomnia are not fully understood. Further research is needed to develop more effective treatments.

Future Research Directions

Future research should evaluate the long-term effectiveness of CBT-I and explore ways to enhance CBT-I effectiveness. 79 . It is also important to understand the causes and mechanisms of insomnia and to develop more effective treatments.

Conclusion

Cognitive behavioral therapy (CBT-I) is an effective treatment for insomnia. 3 72 . CBT-I is shown to have effects that last longer than drug therapy. 14 . However, CBT-I requires effort and time. 15 . CBT-I effectiveness varies from person to person. If you don't see results, consult a doctor or specialist. Don't give up. If you are experiencing insomnia, consult a doctor or specialist to find the right treatment for you.

List of Treatments

Cognitive behavioral therapy (CBT-I), drug therapy, internet-based CBT-I, acupuncture

Keywords
Benefit Keywords
Behavioral treatments
Sleep quality
1
Behavioral therapy improved sleep
Triazolam decreased sleep latency
2
Improved sleep pattern
Improved sleep quality
3
Improved sleep
5
Improved sleep quality
6
Improved understanding of insomnia treatment
7
insomnia treatment
8
Improved sleep quality in older adults
9
Effective treatment
Improved sleep
10
Easier falling asleep
Improved sleep latency
Improved total sleep time
Reduced wakefulness
11
Effective insomnia treatment
No side effects
12
Improved sleep quality
Increased sleep efficiency
Reduced sleep latency
13
Sleep improvement
14
Insomnia treatment
15
Improved insomnia treatment
16
No rebound insomnia
Treat insomnia
17
Sleep improvements
18
Improved sleep
Reduced insomnia
19
Improved sleep
No risk of tolerance or dependency
20
Insomnia treatment
21
Short-term benzodiazepine use helpful
22
Improved sleep
No risk of tolerance or dependency
23
Improved sleep
No risk of tolerance or dependency
24
None reported
25
Improved sleep
26
Improved sleep quality
27
Improve sleep quality
28
Improve sleep quality
Reduce sleep latency
Reduce wakening
29
Insomnia treatment
30
Insomnia treatment
31
Improved insomnia treatment
32
Insomnia treatment
33
Improved sleep onset latency
34
Reduced adverse events
Reduced rebound insomnia
Stable clinical outcomes
37
Improved sleep quality
38
Insomnia improvement
39
Higher remission rates
Improved sleep quality
Increased sleep time
40
Insomnia treatment
41
Insomnia severity reduction
Sleep quality improvement
42
Improved sleep
43
Improves sleep efficiency
Improves sleep quality
Improves sleep time
44
Acupuncture effective
Auricular-plaster effective
46
Improved insomnia
47
Combined intervention for PTSD sleep
48
Improved insomnia
Reduced depression
49
Insomnia treatment
50
Improved depression treatment
51
CBT effective for insomnia
Low-cost self-help
Therapist support enhances effect
52
Improved psychological outcomes
Improved sleep
53
Alternative insomnia treatment
Improve sleep quality
54
Reduce insomnia
Reduce psychiatric symptoms
55
Insomnia treatment
57
Depression reduction
Mood improvement
Nighttime symptom reduction
PTSD symptom reduction
Sleep improvement
58
Insomnia treatment
Reduced psychotic symptoms
59
PI treatment
60
Improved sleep
61
Insomnia treatment
62
Depression treatment
Insomnia relief
63
Insomnia treatment
64
Improved sleep quality
65
Reduced depression
Reduced insomnia
66
Improved sleep
67
Improve mood
Treat insomnia
68
Insomnia treatment
69
Insomnia treatment
Sleep improvement
70
Body warming
Bright light therapy
CBT-I for insomnia
Physical activity
71
Improved insomnia
Improved sleep
72
Partial reinforcement for insomnia
73
Insomnia treatment
74
CBT efficacy
Insomnia treatment
75
Sleep improvement
76
Insomnia treatment
77
Insomnia treatment
78
Long-term insomnia improvement
79
Improved daytime function
Improved psychological functioning
80
Insomnia treatment
81
Depression treatment
Insomnia treatment
82
Insomnia treatment
83
Insomnia treatment
84
Depression reduction
Sleep improvement
85
Improved sleep
86
Improved insomnia severity
87
Insomnia treatment
88
Improved sleep
89
Depression severity reduction
Insomnia treatment
91
CBTI
92
Improved Sleep
93
Improved sleep
Reduced depression
94
Improved insomnia
Reduced depressive symptoms
95
Hypnotic medications
Insomnia treatment
96
Improved depression
97
Improved fatigue
Improved mood
Improved quality of life
98
Potential for insomnia therapy
99
Improved insomnia symptoms
Reduced pain
100
Insomnia treatment
101
PI treatment
102
Sleep improvement
103
Insomnia improvement
104
Improved insomnia treatment
105
CBT-I
Chronic insomnia treatment
106
Improved sleep
Increased CPAP use
107
Improved quality of life
Improved sleep quality
Reduced depressive symptoms
Reduced insomnia severity
108
Improved insomnia treatment
109
Improved insomnia
Safe treatment
110
CBTi
111
Sleep improvement
112
Improves sleep quality
Reduces insomnia severity
114
Improved insomnia
115
Improved sleep
116
Benzodiazepine/hypnotic discontinuation
Insomnia treatment
117
Improved insomnia treatment
118
Daytime symptom improvement
Insomnia treatment
119
Improved insomnia treatment
120
Insomnia treatment
122
Insomnia treatment
123
Improved sleep
Reduced fatigue
Reduced pain
124
Insomnia treatment
125
Improved emotion regulation
Improved insomnia
Reduced alcohol craving
126
Insomnia treatment
127
Mindfulness for hypnotic use
128
MBTI for insomnia
SHEEP for insomnia
129
CBT-I effectiveness
Insomnia treatment
130
Insomnia treatment
131
PRM effectiveness
Sleep disorder treatment
132
Insomnia improvement
133
Reduced Impairment
134
Pharmacological treatments for insomnia
135
Improved sleep quality
136
CBT-I benefits
Insomnia relief
137
Insomnia treatment
SUD recovery
138
Insomnia treatment
Sleep duration
139
Sleep improvement
140
Improved insomnia
Improved mental health
Improved sleep efficiency
Improved sleep onset latency
Improved total sleep time
Improved wake after sleep onset
Improved work and social adjustment
141
Insomnia management in breast cancer patients
142
Improved sleep
Reduced alcohol use
143
Reduced pain symptoms
144
Improved treatment outcome
145
Risk Keywords
Iatrogenic effects of long-term hypnotic use
4
insomnia
sleep disorders
8
Insomnia
13
Slower efficacy than pharmacological methods
20
Addiction
Dependence
Dosing escalation
Tolerance
22
Slower efficacy than pharmacological methods
23
Slower efficacy than pharmacological methods
24
None reported
25
No significant risk
27
Insomnia
32
Risk of harm
34
Medication dependence
40
None reported
43
None mentioned
44
Residual sleep difficulties
48
Limited self-help evidence
Scarce CBT availability
52
Short-term effectiveness of medications
53
Self-medication delay
56
Pharmacologic treatment concerns
57
Insomnia triggers psychosis
59
Insomnia
62
Ineffective for severe depression
63
Need for further treatment
66
Side effects
67
Insomnia
76
Increased medication use
79
None mentioned
82
Sleep worsening
85
Somnolence
89
Adolescent insomnia
92
Dependence
Tolerance
96
Unknown risks
98
Insomnia in depression
101
No side effects reported
104
None
108
Daytime sleepiness
111
Sleepiness risk
112
None reported
117
Insomnia treatment
121
Hypnotic dependence
128
None
134
None reported
143
Literature analysis of 145 papers
Positive Content
134
Neutral Content
9
Negative Content
2
Article Type
106
25
24
20
145
1.

An evaluation of behavioral treatments for insomnia in the older adult.

Author: Engle-FriedmanM, BootzinR R, HazlewoodL, TsaoC

Behavioral treatments
Sleep quality

A study of 53 older adults with insomnia found that various behavioral treatments, including support and sleep hygiene, progressive relaxation, and stimulus control, improved sleep quality and reduced feelings of depression. The study found that stimulus control was the most effective in improving sleep at the end of treatment. Two years later, those who received stimulus control were more likely to use the techniques and had better sleep quality. The study concluded that behavioral therapies are effective in improving sleep and perception of sleep in older adults with insomnia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Efficacy of behavioral versus triazolam treatment in persistent sleep-onset insomnia.

Author: McCluskyH Y, MilbyJ B, SwitzerP K, WilliamsV, WootenV

Behavioral therapy improved sleep
Triazolam decreased sleep latency

This study compared behavioral therapy and triazolam for treating sleep-onset insomnia. Triazolam was expected to improve sleep onset and reduce awakenings, with effects seen quickly, but these effects were predicted to fade over time. Behavioral therapy was expected to improve sleep after several weeks and these improvements were expected to last.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

A controlled comparative investigation of psychological treatments for chronic sleep-onset insomnia.

Author: EspieC A, LindsayW R, BrooksD N, HoodE M, TurveyT

Improved sleep pattern
Improved sleep quality

A study comparing different treatments for chronic insomnia found that progressive relaxation and stimulus control were effective in improving sleep patterns and quality, with improvements maintained at 17 months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Nondrug treatment trials in psychophysiologic insomnia.

Author: GuilleminaultC, ClerkA, BlackJ, LabanowskiM, PelayoR, ClamanD

Iatrogenic effects of long-term hypnotic use

Due to potential problems with long-term use of sleeping pills, patients and doctors prefer non-drug treatments for insomnia. However, these treatments need to provide relief quickly to be acceptable to patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Sleep compression and sleep education for older insomniacs: self-help versus therapist guidance.

Author: RiedelB W, LichsteinK L, DwyerW O

Improved sleep

This study evaluated a treatment package for insomnia in older adults, combining a bedtime restriction strategy with educational materials. Insomniacs who received the self-help video treatment showed improvement in sleep measures. Adding therapist guidance further enhanced the treatment outcome, particularly for sleep latency, wake time after sleep onset, and sleep satisfaction. While the control group also showed some improvement over time, treated insomniacs generally performed better.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy.

Author: MorinC M, CulbertJ P, SchwartzS M

Improved understanding of insomnia treatment

This study used a meta-analysis to review the effectiveness and long-term benefits of psychological treatments for chronic insomnia. The research was prompted by the recognized influence of psychological factors on insomnia, limitations of sleep medications, and patients' preference for non-drug treatments.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

[The effect of acupuncture in the treatment of insomnia. Clinical study of subjective and objective evaluation].

Author: MontakabH, LangelG

insomnia treatment
insomnia
sleep disorders

This paper discusses the importance of non-chemical treatments for insomnia and highlights the potential of acupuncture as a personalized treatment. It emphasizes the need for further research on the effects of acupuncture on sleep using polysomnography.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

9.

Cognitive-behavior therapy for late-life insomnia.

Author: MorinC M, KowatchR A, BarryT, WaltonE

Improved sleep quality in older adults

This randomized waiting-list control group study of 24 older adults with persistent psychophysiological insomnia found that cognitive-behavioral therapy was effective in improving sleep quality.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

10.

[Interpersonal psychotherapy in treatment of patients with primary insomnia--preliminary data of polysomnographic macro-analysis].

Author: Müller-PopkesK, HajakG

Effective treatment
Improved sleep

This study compared interpersonal psychotherapy for insomnia (IPT-I) with progressive relaxation training (PR) for treating primary insomnia. IPT-I showed significant improvements in total sleep time, sleep efficiency, and wake time after sleep onset, while PR showed only slight improvement. The findings suggest that IPT-I is a promising treatment for primary insomnia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

11.

[Behavior and cognitive treatments for insomnia. An alternative to pharmacotherapy].

Author: BaillargeonL

Easier falling asleep
Improved sleep latency
Improved total sleep time
Reduced wakefulness

Relaxation training, sleep restriction, and stimulus control were the most effective interventions for insomnia. Good sleep habits are only moderately effective and should be combined with other interventions.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : French

12.

[The efficacy of sleep hygiene measures in the treatment of insomnia].

Author: Martínez-ManzanoC, Levario-CarrilloM

Effective insomnia treatment
No side effects

This study compared the effectiveness of sleep hygiene, placebo, and benzodiazepines in treating psychophysiologic insomnia. All three treatments showed similar effectiveness, with sleep hygiene being effective and having no risk of side effects. The study recommends sleep hygiene as the first-choice therapy for insomnia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

13.

Can we mix behavioral therapy with hypnotics when treating insomniacs?

Author: HauriP J

Improved sleep quality
Increased sleep efficiency
Reduced sleep latency
Insomnia

This study examined the effectiveness of behavioral therapy for insomnia, comparing outcomes for patients who were allowed to use hypnotics occasionally to those who were asked to abstain from all hypnotics. While both groups showed improvement immediately after treatment, those who abstained from hypnotics had better long-term outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Behavioral and pharmacological therapies for late-life insomnia: a randomized controlled trial.

Author: MorinC M, ColecchiC, StoneJ, SoodR, BrinkD

Sleep improvement

Behavioral therapy is more effective than pharmacotherapy for the short-term management of insomnia in late life. In a randomized, placebo-controlled clinical trial, the combined approach of cognitive-behavior therapy and pharmacotherapy showed a trend for improvement in sleep more than either of its single components. Subjects treated with behavior therapy sustained their clinical gains at follow-up, whereas those treated with drug therapy alone did not.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

Self-help treatment for insomnia: bibliotherapy with and without professional guidance.

Author: MimeaultV, MorinC M

Insomnia treatment

This study compared the effectiveness of cognitive-behavioral bibliotherapy (BT) alone to BT with weekly phone consultations in treating primary insomnia. Both treatments were effective, suggesting that BT can be a valuable self-help approach for insomnia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

Psychological treatment of secondary insomnia.

Author: LichsteinK L, WilsonN M, JohnsonC T

Improved insomnia treatment

While most psychological treatments for insomnia focus on those with insomnia caused by psychological factors, this study investigated the effectiveness of treatment for older adults with insomnia caused by other medical or mental health conditions (secondary insomnia). The study found that those who received relaxation and stimulus control therapy showed significant improvements in sleep quality compared to those who did not receive treatment. The authors suggest that the success of the treatment may be due to the difficulty in distinguishing between primary and secondary insomnia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Eight weeks of non-nightly use of zolpidem for primary insomnia.

Author: WalshJ K, RothT, RandazzoA, ErmanM, JamiesonA, ScharfM, SchweitzerP K, WareJ C

No rebound insomnia
Treat insomnia

Intermittent use of zolpidem 10 mg was effective in treating chronic insomnia without evidence of rebound insomnia or increased frequency of pill taking. A randomized, double-blind, placebo-controlled trial involving 163 patients with insomnia found that intermittent zolpidem significantly improved insomnia severity compared to placebo. There were no significant effects on quality of life or neurocognitive measures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial.

Author: EdingerJ D, WohlgemuthW K, RadtkeR A, MarshG R, QuillianR E

Sleep improvements

Cognitive behavioral therapy (CBT) represents a viable intervention for primary sleep-maintenance insomnia. CBT led to clinically significant sleep improvements within 6 weeks that endured through 6 months of follow-up.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Efficacy of two behavioral treatment programs for comorbid geriatric insomnia.

Author: RybarczykBruce, LopezMartita, BensonRodney, AlstenChristopher, StepanskiEdward

Improved sleep
Reduced insomnia

Older adults with both insomnia and other health problems were studied to see if behavioral treatments for insomnia were effective. Cognitive-behavioral therapy (CBT) showed significant improvements in sleep for 54% of participants, while a home-based audio relaxation treatment (HART) showed improvement for 35%. These results suggest that home-based interventions may be a good first-line, low-cost treatment option.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

20.

Cognitive behavioural interventions for sleep problems in adults aged 60+.

Author: MontgomeryP, DennisJ

Improved sleep
No risk of tolerance or dependency
Slower efficacy than pharmacological methods

Sleep problems become more common with age. While not all changes in sleep are serious, severe sleep problems can lead to depression, cognitive problems, lower quality of life, increased stress for caregivers, and higher healthcare costs. While medications are commonly used to treat sleep problems, non-drug approaches can also be helpful. Cognitive and behavioral therapies aim to improve sleep by changing bad sleep habits, encouraging healthy sleep practices, and addressing negative thoughts about sleep.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Behavioral treatment of insomnia in older adults: an open clinical trial comparing two interventions.

Author: PallesenS, NordhusI H, KvaleG, NielsenG H, HavikO E, JohnsenB H, SkjøtskiftS

Insomnia treatment

This study compared two behavioral treatments for insomnia in older adults: sleep hygiene plus stimulus control and sleep hygiene plus relaxation tape. Both treatments improved sleep parameters, including sleep onset and total sleep time, with the benefits lasting six months. Improvements were greater for nighttime measures than daytime measures or unrelated behaviors. There was no difference in effectiveness between the two treatment approaches.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Benzodiazepines and related drugs for insomnia in palliative care.

Author: HirstA, SloanR

Short-term benzodiazepine use helpful
Addiction
Dependence
Dosing escalation
Tolerance

Insomnia, characterized by difficulty sleeping and daytime problems, is a common issue. Benzodiazepines are a frequently used treatment, but they are not recommended for long-term use due to potential for tolerance, dependence, and addiction. There is no clear consensus on their use in people with progressive illnesses who might need long-term sleep assistance as their condition worsens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Physical exercise for sleep problems in adults aged 60+.

Author: MontgomeryP, DennisJ

Improved sleep
No risk of tolerance or dependency
Slower efficacy than pharmacological methods

Sleep problems become more common as people age. While not all changes in sleep are serious, severe sleep problems can lead to depression, cognitive problems, lower quality of life, increased stress for caregivers, and higher healthcare costs. While medications are commonly used to treat sleep problems, non-drug approaches can also be helpful. Regular exercise can promote relaxation and raise body temperature, both of which can improve sleep.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Cognitive behavioural interventions for sleep problems in adults aged 60+.

Author: MontgomeryP, DennisJ

Improved sleep
No risk of tolerance or dependency
Slower efficacy than pharmacological methods

Sleep problems become more common as people age. While not all changes in sleep are serious, severe sleep problems can lead to depression, cognitive problems, lower quality of life, increased stress for caregivers, and higher healthcare costs. While medications are commonly used to treat sleep problems, non-drug approaches can also be helpful. Cognitive and behavioral therapies aim to improve sleep by changing bad sleep habits, encouraging healthy sleep practices, and addressing negative thoughts about sleep.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Treatment of primary insomnia with melatonin: a double-blind, placebo-controlled, crossover study.

Author: Almeida MontesLuis G, Ontiveros UribeMarta P, Cortés SotresJosé, Heinze MartinGerardo

None reported
None reported

Melatonin did not improve sleep quality or quantity in patients with primary insomnia. There were no significant differences in sleep EEG, amount or subjective quality of sleep, or side effects between the placebo, 0.3-mg melatonin, or 1.0-mg melatonin treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Cognitive behaviour therapy for primary insomnia: can we rest yet?

Author: HarveyAllison G, TangNicole K Y

Improved sleep

Cognitive behavior therapy (CBT) has proven effective for treating primary insomnia. The study argues that there is still room for improvement in CBT for insomnia and suggests directions for future research to enhance its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Psychological treatment for insomnia in the management of long-term hypnotic drug use: a pragmatic randomised controlled trial.

Author: MorganKevin, DixonSimon, MathersNigel, ThompsonJoanne, TomenyMaureen

Improved sleep quality
No significant risk

Cognitive behavior therapy (CBT) for insomnia improved sleep quality and reduced hypnotic consumption in long-term hypnotic users with chronic sleep difficulties.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Self-help treatment for insomnia: a randomized controlled trial.

Author: MorinCharles M, Beaulieu-BonneauSimon, LeBlancMélanie, SavardJosée

Improve sleep quality

A self-help behavioral intervention was effective in alleviating a broad range of insomnia symptomatology in a community sample. Treated participants averaged nightly gains of 21 minutes of sleep and a reduction of 20 minutes of wakefulness, with a corresponding increase of 4% in sleep efficiency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in middle-aged adults and in older adults 55+ years of age.

Author: IrwinMichael R, ColeJason C, NicassioPerry M

Improve sleep quality
Reduce sleep latency
Reduce wakening

This meta-analysis of randomized controlled trials found that behavioral interventions are effective for treating insomnia, with similar effects across different treatment modalities, including cognitive-behavioral therapy, relaxation, and behavioral-only approaches.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

30.

Comparison of sleep condition and sleep-related psychological activity after cognitive-behavior and pharmacological therapy for chronic insomnia.

Author: WuRengang, BaoJinfeng, ZhangChungai, DengJun, LongChunling

Insomnia treatment

This study compared the effects of pharmacological and behavioral treatments for chronic insomnia on sleep quality, sleep-related psychological activity, and daytime function, finding that both approaches improve sleep but further research is needed on their impact on psychological well-being and daily function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial.

Author: SivertsenBørge, OmvikSiri, PallesenStåle, BjorvatnBjørn, HavikOdd E, KvaleGerd, NielsenGeir Høstmark, NordhusInger Hilde

Insomnia treatment

This study calls for blinded placebo-controlled trials comparing psychological and pharmacological treatments for insomnia in older adults, given the prevalence of insomnia in this population and the need for evidence-based treatment approaches.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Psychological and behavioral treatment of insomnia:update of the recent evidence (1998-2004).

Author: MorinCharles M, BootzinRichard R, BuysseDaniel J, EdingerJack D, EspieColin A, LichsteinKenneth L

Improved insomnia treatment
Insomnia

This review updates a previous review on psychological and behavioral therapies for insomnia, recognizing the importance of these factors in treating sleep difficulties. The review, commissioned by the American Academy of Sleep Medicine, provides updated evidence on the effectiveness of these therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Effects of a brief behavioral treatment for late-life insomnia: preliminary findings.

Author: GermainAnne, MoulDouglas E, FranzenPeter L, MiewaldJean M, ReynoldsCharles F, MonkTimothy H, BuysseDaniel J

Insomnia treatment

The study investigated the effects of a brief behavioral treatment for insomnia in older adults, considering the safety concerns associated with hypnotics and the time-consuming nature of standard behavioral treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

34.

The efficacy and safety of drug treatments for chronic insomnia in adults: a meta-analysis of RCTs.

Author: BuscemiNina, VandermeerBen, FriesenCarol, BialyLiza, TubmanMichelle, OspinaMaria, KlassenTerry P, WitmansManisha

Improved sleep onset latency
Risk of harm

Benzodiazepines and non-benzodiazepines are effective treatments in the management of chronic insomnia, although they pose a risk of harm.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Psychological treatment of insomnia in hypnotic-dependant older adults.

Author: SoeffingJames P, LichsteinKenneth L, NauSidney D, McCraeChristina S, WilsonNancy M, AguillardR Neal, LesterKristin W, BushAndrew J

The study aimed to investigate whether cognitive-behavioral therapy would have an impact on insomnia in older adults who are chronic users of sleep medication and have current insomnia but are stable in their medication usage during treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

36.

Self-help therapy for insomnia: a meta-analysis.

Author: van StratenAnnemieke, CuijpersPim

Insomnia is a common problem with significant impact on quality of life and work productivity. This study explores the potential of self-help interventions as a cost-effective and accessible alternative to traditional face-to-face treatment for insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

37.

Intermittent and long-term use of sedative hypnotics.

Author: PerlisMichael, GehrmanPhilip, RiemannDieter

Reduced adverse events
Reduced rebound insomnia
Stable clinical outcomes

This review critically evaluates the evidence base for intermittent and long-term dosing with hypnotics for the treatment of chronic insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Trazodone improves the results of cognitive behaviour therapy of primary insomnia in non-depressed patients.

Author: ZavesickaLucie, BrunovskyMartin, HoracekJiri, MatousekMilos, SosPeter, KrajcaVladimir, HöschlCyril

Improved sleep quality

This study evaluated the clinical efficacy of CBT, singly and combined with trazodone pharmacotherapy, for primary insomnia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

[Observation on the therapeutic effect of neck clustered needling on insomnia].

Author: QiLi-zhen, MaXiao-peng, YangLing

Insomnia improvement

Neck clustered needling was more effective than oral Alprazolam in treating insomnia, improving sleep quality and overall well-being.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

40.

Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial.

Author: MorinCharles M, VallièresAnnie, GuayBernard, IversHans, SavardJosée, MéretteChantal, BastienCélyne, BaillargeonLucie

Higher remission rates
Improved sleep quality
Increased sleep time
Medication dependence

Combined cognitive behavioral therapy and zolpidem produced greater improvements in sleep latency, time awake after sleep onset, and sleep efficiency during acute therapy than cognitive behavioral therapy alone. Although both treatments resulted in similar remission rates during acute treatment, combined therapy led to higher remission rates during extended therapy and at follow-up. Discontinuing medication during maintenance CBT optimized long-term outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

42.

Logging on for better sleep: RCT of the effectiveness of online treatment for insomnia.

Author: VincentNorah, LewyckySamantha

Insomnia severity reduction
Sleep quality improvement

This study found that a 5-week, online treatment for insomnia significantly improved sleep quality, insomnia severity, and daytime fatigue. The treatment group also showed significant changes in pre-sleep cognitive arousal and dysfunctional beliefs about sleep. However, there was a 33% attrition rate, and dropouts were more likely to have been referred for treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Efficacy of an Internet-based behavioral intervention for adults with insomnia.

Author: RitterbandLee M, ThorndikeFrances P, Gonder-FrederickLinda A, MageeJoshua C, BaileyElaine T, SaylorDrew K, MorinCharles M

Improved sleep
None reported

An Internet-based cognitive behavioral therapy intervention for insomnia significantly improved sleep quality compared to a wait-list control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

44.

[Scalp penetration acupuncture for insomnia: a randomized controlled trial].

Author: ZhouZhang-ling, ShiXian, LiShao-dan, GuanLing

Improves sleep efficiency
Improves sleep quality
Improves sleep time
None mentioned

The therapeutic effects of scalp penetration acupuncture are better than those of routine acupuncture, especially for improving sleep quality, sleep time and sleep efficiency.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

45.

Homeopathy for insomnia: a systematic review of research evidence.

Author: CooperKaty L, ReltonClare

This systematic review examined the effectiveness of homeopathy for the treatment of insomnia. Four randomized controlled trials (RCTs) compared homeopathic medicines to placebo, but none demonstrated a statistically significant difference in outcomes. The existing RCTs were of poor quality and underpowered. Well-conducted studies are needed to examine the clinical and cost effectiveness of homeopathy for insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Clinical observation on acupuncture treatment of intractable insomnia.

Author: LiLing-Feng, LuJian-Hua

Acupuncture effective
Auricular-plaster effective

The study found that body acupuncture plus auricular-plaster therapy showed a better effect for intractable insomnia compared to the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Efficacy of brief behavioral treatment for chronic insomnia in older adults.

Author: BuysseDaniel J, GermainAnne, MoulDouglas E, FranzenPeter L, BrarLaurie K, FletcherMary E, BegleyAmy, HouckPatricia R, MazumdarSati, ReynoldsCharles F, MonkTimothy H

Improved insomnia

This study examines the effectiveness of a short-term behavioral therapy program (BBTI) for treating chronic insomnia in older adults, comparing it to a control group that received general information. The study aims to determine if BBTI can be a useful treatment option for older adults with insomnia, particularly considering that more intensive therapies are not always accessible.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

48.

A multi-component cognitive-behavioral intervention for sleep disturbance in veterans with PTSD: a pilot study.

Author: UlmerChristi S, EdingerJack D, CalhounPatrick S

Combined intervention for PTSD sleep
Residual sleep difficulties

A combination of a nightmare-specific intervention and CBT for insomnia may lead to greater reductions in PTSD-related sleep disturbances than either treatment alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

49.

Brief behavioral therapy for refractory insomnia in residual depression: an assessor-blind, randomized controlled trial.

Author: WatanabeNorio, FurukawaToshi A, ShimoderaShinji, MorokumaIppei, KatsukiFujika, FujitaHirokazu, SasakiMegumi, KawamuraChihiro, PerlisMichael L

Improved insomnia
Reduced depression

Adding brief behavioral therapy for insomnia to usual clinical care produced statistically significant and clinically substantive added benefits in patients with residual depression and treatment refractory insomnia. Brief behavioral therapy for insomnia plus TAU resulted in significantly lower ISI scores than TAU alone at 8 weeks (P < .0005) and the sleep efficiency for the combination was also significantly better than that for TAU alone (P = .015).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Sleep America: managing the crisis of adult chronic insomnia and associated conditions.

Author: KrausStefanie S, RabinLaura A

Insomnia treatment

Chronic insomnia affects 10-15% of the U.S. population and is often under-recognized and under-treated. This highlights the need for public policy attention to address chronic insomnia and co-occurring conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Insomnia moderates outcome of serotonin-selective reuptake inhibitor treatment in depressed youth.

Author: EmslieGraham J, KennardBetsy D, MayesTaryn L, NakoneznyPaul A, ZhuLian, TaoRongrong, HughesCarroll, CroarkinPaul

Improved depression treatment

This study highlights the common occurrence of insomnia in young people with depression and its association with poorer treatment outcomes. The study points to the need for research on how insomnia affects the effectiveness of treatment for depression, particularly for medications that can worsen sleep quality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

52.

Efficacy of a behavioral self-help treatment with or without therapist guidance for co-morbid and primary insomnia--a randomized controlled trial.

Author: JernelövSusanna, LekanderMats, BlomKerstin, RydhSara, LjótssonBrjánn, AxelssonJohn, KaldoViktor

CBT effective for insomnia
Low-cost self-help
Therapist support enhances effect
Limited self-help evidence
Scarce CBT availability

This study investigated the effectiveness of a cognitive behaviorally based self-help book for treating insomnia with or without therapist telephone support.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review.

Author: MitchellMatthew D, GehrmanPhilip, PerlisMichael, UmscheidCraig A

Improved psychological outcomes
Improved sleep
Short-term effectiveness of medications

Cognitive behavioral therapy for insomnia (CBT-I) was more effective than benzodiazepines and non-benzodiazepine drugs in the long term for treating insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

A comparison between acupuncture versus zolpidem in the treatment of primary insomnia.

Author: TuJung-Hung, ChungWei-Ching, YangChun-Yuh, TzengDong-Sheng

Alternative insomnia treatment
Improve sleep quality

Acupuncture and zolpidem showed similar improvements in sleep quality for patients with primary insomnia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

55.

Effectiveness of abbreviated CBT for insomnia in psychiatric outpatients: sleep and depression outcomes.

Author: WagleyJ Nile, RybarczykBruce, NayWilliam T, DanishSteven, LundHannah G

Reduce insomnia
Reduce psychiatric symptoms

Cognitive-behavioral therapy for insomnia (CBT-I) may be an effective supplemental treatment for psychiatric outpatients with comorbid insomnia, reducing both insomnia and other psychiatric symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

The insomnia patient perspective, a narrative review.

Author: CheungJanet M Y, BartlettDelwyn J, ArmourCarol L, SainiBandana

Self-medication delay

Insomnia is a common sleep disorder that has significant costs. Many people with insomnia self-treat, delaying professional help. This review examined how research has considered the patient perspective on insomnia treatment and found that delays in seeking help are linked to barriers within the healthcare system and patients' beliefs about their condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

57.

Insomnia.

Author: BuysseDaniel J

Insomnia treatment
Pharmacologic treatment concerns

Insomnia is a common condition with a prevalence of 10% to 20%. Behavioral treatments are often effective, but pharmacologic interventions may be necessary in some cases.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical ConferenceA conference/presentation where healthcare professionals discuss and share cases, treatment strategies, and best practices.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Efficacy of a cognitive-behavioral treatment for insomnia and nightmares in Afghanistan and Iraq veterans with PTSD.

Author: MargoliesSkye Ochsner, RybarczykBruce, VranaScott R, LeszczyszynDavid J, LynchJohn

Depression reduction
Mood improvement
Nighttime symptom reduction
PTSD symptom reduction
Sleep improvement

Cognitive-behavioral therapy for insomnia (CBT-I) combined with adjunctive imagery rehearsal therapy (IRT) for nightmares was found to improve sleep and reduce PTSD symptoms in combat veterans. Participants who received CBT-I/IRT reported improved subjectively and objectively measured sleep, a reduction in PTSD symptom severity and PTSD-related nighttime symptoms, and a reduction in depression and distressed mood compared to the waitlist control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

59.

The effects of using cognitive behavioural therapy to improve sleep for patients with delusions and hallucinations (the BEST study): study protocol for a randomized controlled trial.

Author: FreemanDaniel, StartupHelen, MyersElissa, HarveyAllison, GeddesJohn, YuLy-Mee, ZaiwallaZenobia, Luengo-FernandezRamon, FosterRussell, ListerRachel

Insomnia treatment
Reduced psychotic symptoms
Insomnia triggers psychosis

This study explores the link between insomnia and psychotic symptoms in patients with psychosis. The study found that treating insomnia with cognitive behavioral therapy for insomnia (CBT-I) significantly reduced both sleep problems and delusional symptoms in 15 patients. The study proposes a randomized controlled trial to further evaluate the effectiveness of CBT-I in reducing both insomnia and psychotic symptoms, ultimately aiming for a larger-scale study to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

The effect of a homeopathic complex on psychophysiological onset insomnia in males: a randomized pilot study.

Author: HarrisonCaroline Christel, SolomonElizabeth Margaret, PellowJanice

PI treatment

Psychophysiological insomnia (PI) is a common sleep problem where people stay awake for more than 30 minutes because of learned behaviors and anxiety at bedtime. This can negatively affect health, work, and relationships. While sleep medications have drawbacks, homeopathic treatments may offer a potential alternative.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

Are changes in worry associated with treatment response in cognitive behavioral therapy for insomnia?

Author: SunnhedRikard, Jansson-FröjmarkMarkus

Improved sleep

This study will investigate the long-term association between insomnia-related worry and outcomes following cognitive behavior therapy for insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

62.

Predictors of treatment response to brief behavioral treatment of insomnia (BBTI) in older adults.

Author: TroxelWendy M, ConradTyler S, GermainAnne, BuysseDaniel J

Insomnia treatment
Insomnia

This study investigates factors that predict successful treatment response to brief behavioral treatment of insomnia (BBTI) in older adults. Demographic, clinical, and sleep characteristics are examined to understand who benefits most from this intervention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

63.

Do manualized treatments for depression reduce insomnia symptoms?

Author: YonAdriana, ScoginForrest, DiNapoliElizabeth A, McPherronJesse, AreanPatricia A, BowmanDaniel, JamisonChristine S, KarpeJennifer A, LatourDavid, ReynoldsCharles F, RohenNoelle, PardiniJamie E L, ThompsonLarry W

Depression treatment
Insomnia relief
Ineffective for severe depression

Participants receiving a psychological treatment for depression experienced significantly more relief from symptoms of insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

64.

Cognitive and behavioural therapy for insomnia (CBT-I) in psychiatric populations: a systematic review.

Author: TaylorDaniel J, PruiksmaKristi E

Insomnia treatment

Insomnia is common in people with mental health conditions. While it can be a symptom of these disorders or a consequence of them, insomnia can become a separate problem and worsen mental health conditions if not treated. Cognitive behavioral therapy for insomnia (CBT-I) is now recommended as the first-line treatment for insomnia. Research suggests that CBT-I is generally effective for insomnia in people with depression, anxiety, PTSD, and substance abuse disorders, and may even improve those conditions as well. More research is needed, but CBT-I appears to be a viable treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

A meta-analysis of group cognitive behavioral therapy for insomnia.

Author: KoffelErin A, KoffelJonathan B, GehrmanPhilip R

Improved sleep quality

While cognitive behavioral therapy for insomnia (CBT-I) is the preferred treatment, individual therapy is often unavailable. This review examined the effectiveness of group CBT-I for insomnia, demonstrating its efficacy in improving sleep quality and pain outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

66.

Internet treatment addressing either insomnia or depression, for patients with both diagnoses: a randomized trial.

Author: BlomKerstin, JernelövSusanna, KraepelienMartin, BergdahlMalin Olséni, JungmarkerKristina, AnkartjärnLinda, LindeforsNils, KaldoViktor

Reduced depression
Reduced insomnia
Need for further treatment

Internet-delivered cognitive behavior therapy (ICBT) for insomnia was more effective than ICBT for depression in patients with both insomnia and depression. Patients receiving insomnia treatment used less sleep medication and reported less need for further insomnia treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Effect of acupuncture on patients with insomnia: study protocol for a randomized controlled trial.

Author: HanKyung-Hun, KimSang-Young, ChungSun-Yong

Improved sleep
Side effects

This study proposes a randomized controlled trial to evaluate the effectiveness of intradermal acupuncture for insomnia. The trial will compare the effects of real acupuncture points (PC6, SP6, HT7, KI6, and BL62) to sham acupuncture points in patients with insomnia. The study will assess insomnia symptoms, emotional states, sleep quality, cognitive functioning, and electro-physiological changes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

The Sleep Or Mood Novel Adjunctive therapy (SOMNA) trial: a study protocol for a randomised controlled trial evaluating an internet-delivered cognitive behavioural therapy program for insomnia on outcomes of standard treatment for depression in men.

Author: CockayneNicole L, ChristensenHelen M, GriffithsKathleen M, NaismithSharon L, HickieIan B, ThorndikeFrances P, RitterbandLee M, GlozierNick S

Improve mood
Treat insomnia

Insomnia is a significant risk factor for depression. This study evaluates the effectiveness of internet-delivered cognitive behavioral therapy for insomnia as an adjunct treatment for depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

69.

Effectiveness of a CBT Intervention for Persistent Insomnia and Hypnotic Dependency in an Outpatient Psychiatry Clinic.

Author: TaylorHannah Lund, RybarczykBruce D, NayWilliam, LeszczyszynDavid

Insomnia treatment

This study examines the use of cognitive behavioral therapy for insomnia (CBT-I) in people with persistent insomnia who are receiving psychiatric treatment and are still experiencing sleep problems despite using sleep medication. The study also includes an optional module to help patients stop taking sleep medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

70.

Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis.

Author: TrauerJames M, QianMary Y, DoyleJoseph S, RajaratnamShantha M W, CunningtonDavid

Insomnia treatment
Sleep improvement

CBT-i is an effective treatment for adults with chronic insomnia, with clinically meaningful effect sizes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Cognitive Behavioral Therapy for Insomnia Comorbid With Psychiatric and Medical Conditions: A Meta-analysis.

Author: WuJade Q, ApplemanErica R, SalazarRobert D, OngJason C

Improved insomnia
Improved sleep

CBT-I is effective for improving insomnia symptoms and sleep parameters in patients with comorbid insomnia. It has a small to medium positive effect on comorbid outcomes, with larger effects on psychiatric conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

73.

Durability of treatment response to zolpidem with three different maintenance regimens: a preliminary study.

Author: PerlisMichael, GrandnerMichael, ZeeJarcy, BremerErin, WhinneryJulia, BarillaHolly, AndaliaPriscilla, GehrmanPhil, MoralesKnashawn, ThaseMichael, BootzinRichard, AderRobert

Partial reinforcement for insomnia

The study compared partial reinforcement, nightly, and intermittent dosing strategies for managing chronic insomnia, suggesting that partial reinforcement may be a promising long-term maintenance therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

74.

Measuring Treatment Outcomes in Comorbid Insomnia and Fibromyalgia: Concordance of Subjective and Objective Assessments.

Author: MundtJennifer M, CrewEarl C, KrietschKendra, RothAlicia J, VatthauerKarlyn, RobinsonMichael E, StaudRoland, BerryRichard B, McCraeChristina S

Insomnia treatment

Actigraphy can underestimate wakefulness compared to sleep diaries and polysomnography (PSG). This study examines the concordance of these three methods in assessing insomnia, particularly when insomnia co-occurs with chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

75.

Group cognitive behavioural treatment for insomnia in primary care: a randomized controlled trial.

Author: CapeJ, LeibowitzJ, WhittingtonC, EspieC A, PillingS

CBT efficacy
Insomnia treatment

This study evaluates the effectiveness of brief cognitive behavioral therapy (CBT) groups for insomnia compared to treatment as usual (TAU) in a primary-care mental health setting.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

76.

Internet-Delivered Cognitive Behavioral Therapy to Treat Insomnia: A Systematic Review and Meta-Analysis.

Author: SeyffertMichael, LagisettyPooja, LandgrafJessica, ChopraVineet, PfeifferPaul N, ConteMarisa L, RogersMary A M

Sleep improvement
Insomnia

Internet-delivered cognitive behavioral therapy (CBT) for insomnia is effective in improving sleep efficiency, reducing insomnia severity, and improving sleep quality in adults. It offers a readily accessible and effective treatment option for insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial.

Author: MorinCharles M, EdingerJack D, KrystalAndrew D, BuysseDaniel J, Beaulieu-BonneauSimon, IversHans

Insomnia treatment

Chronic insomnia is a common problem that affects mental health, overall well-being, and the economy. While cognitive behavioral therapy (CBT) and medications are common treatments, there's limited research comparing them directly or exploring using them sequentially for those who don't respond to initial treatment. This study aims to address these gaps in research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

78.

Cost-effectiveness of i-Sleep, a guided online CBT intervention, for patients with insomnia in general practice: protocol of a pragmatic randomized controlled trial.

Author: van der ZweerdeTanja, LanceeJaap, SlottjePauline, BosmansJudith, Van SomerenEus, ReynoldsCharles, CuijpersPim, van StratenAnnemieke

Insomnia treatment

This study presents the protocol for a study investigating the feasibility, effectiveness, and cost-effectiveness of a guided online intervention (i-Sleep) for insomnia in patients who seek help from their general practitioner.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Three-Year Follow-Up of Insomnia and Hypnotics after Controlled Internet Treatment for Insomnia.

Author: BlomKerstin, JernelövSusanna, RückChristian, LindeforsNils, KaldoViktor

Long-term insomnia improvement
Increased medication use

Guided Internet-based cognitive behavioral therapy for insomnia showed significant and lasting improvements in insomnia severity and sleep medication use, with a 74% reduction in insomnia diagnosis after 36 months.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

80.

Cognitive-behavior therapy singly and combined with medication for persistent insomnia: Impact on psychological and daytime functioning.

Author: MorinCharles M, Beaulieu-BonneauSimon, BélangerLynda, IversHans, Sánchez OrtuñoMontserrat, VallièresAnnie, SavardJosée, GuayBernard, MéretteChantal

Improved daytime function
Improved psychological functioning

This study evaluated the impact of cognitive-behavioral therapy (CBT), alone and combined with medication, on daytime and psychological functioning in individuals with chronic insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

81.

Computerized Cognitive Behavioral Therapy for Insomnia in a Community Health Setting.

Author: FeuersteinSeth, HodgesSarah E, KeenaghanBrian, BessetteAndrew, ForseliusErica, MorganPeter T

Insomnia treatment

Insomnia is common, especially in people with mental health conditions, where it can worsen their condition and vice versa. While cognitive behavioral therapy for insomnia (CBT-I) is considered the best treatment, it can be difficult to access for people with low income. This study investigates the potential of computer-based CBT-I (cb-CBT-I) as a cost-effective way to make this treatment more accessible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

82.

Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial.

Author: ManberRachel, BuysseDaniel J, EdingerJack, KrystalAndrew, LutherJames F, WisniewskiStephen R, TrockelMickey, KraemerHelena C, ThaseMichael E

Depression treatment
Insomnia treatment
None mentioned

This study evaluated the efficacy of combining depression pharmacotherapy with cognitive-behavioral therapy for insomnia (CBT-I) in individuals with comorbid insomnia and major depressive disorder (MDD).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

83.

Effect of a Web-Based Cognitive Behavior Therapy for Insomnia Intervention With 1-Year Follow-up: A Randomized Clinical Trial.

Author: RitterbandLee M, ThorndikeFrances P, IngersollKaren S, LordHolly R, Gonder-FrederickLinda, FrederickChristina, QuiggMark S, CohnWendy F, MorinCharles M

Insomnia treatment

Cognitive behavioral therapy for insomnia (CBT-I) is the recommended treatment for chronic insomnia, but there is a shortage of therapists trained to deliver it. While online CBT-I has shown promise, its long-term effectiveness for people with chronic insomnia needs further study.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

84.

Effect and safety of paroxetine combined with zolpidem in treatment of primary insomnia.

Author: YuZ H, XuX H, WangS D, SongM F, LiuY, YinY, MaoH J, TangG Z

Insomnia treatment

This study investigated the effectiveness of zolpidem combined with paroxetine in the treatment of primary insomnia. The study found that the combination treatment was more effective than zolpidem treatment alone in sleep maintenance and early morning awakenings.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

85.

Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial.

Author: CarneyColleen E, EdingerJack D, KuchibhatlaMaragatha, LachowskiAngela M, BogouslavskyOlya, KrystalAndrew D, ShapiroColin M

Depression reduction
Sleep improvement
Sleep worsening

Cognitive behavioral therapy for insomnia (CBT-I) combined with antidepressant medication (AD) was more effective in improving objective sleep compared to treatment targeting solely depression or solely insomnia. All groups, even those not receiving depression-focused treatment, improved on depression, suggesting potential antidepressant properties of CBT-I.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

86.

The Short-Term Efficacy of an Unguided Internet-Based Cognitive-Behavioral Therapy for Insomnia: A Randomized Controlled Trial With a Six-Month Nonrandomized Follow-Up.

Author: HagatunSusanne, VedaaØystein, NordgreenTine, SmithOtto R F, PallesenStåle, HavikOdd E, BjorvatnBjørn, ThorndikeFrances P, RitterbandLee M, SivertsenBørge

Improved sleep

This study evaluated the short-term efficacy of an unguided Internet-based cognitive-behavioral treatment program for insomnia (CBTi), called SHUTi (Sleep Healthy Using the Internet).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

87.

Cognitive and behavioral therapies in the treatment of insomnia: A meta-analysis.

Author: van StratenAnnemieke, van der ZweerdeTanja, KleiboerAnnet, CuijpersPim, MorinCharles M, LanceeJaap

Improved insomnia severity

This meta-analysis examines the effectiveness of cognitive behavioral treatment for insomnia (CBTI) for managing insomnia. The study concludes that CBTI is effective in treating insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

88.

Improving insomnia in primary care patients: A randomized controlled trial of nurse-led group treatment.

Author: SandlundChristina, HettaJerker, NilssonGunnar H, EkstedtMirjam, WestmanJeanette

Insomnia treatment

Insomnia is common and people often seek help from their primary care doctor. While sleep medications are often prescribed, cognitive behavioral therapy for insomnia is the recommended treatment, but is not widely available in primary care settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

89.

Treatment of insomnia with tricyclic antidepressants: a meta-analysis of polysomnographic randomized controlled trials.

Author: LiuYang, XuXiaomin, DongMeixue, JiaShiyu, WeiYoudong

Improved sleep
Somnolence

Tricyclic antidepressants (TCAs) were found to be an effective treatment for insomnia, as they were found to improve sleep outcome measures, with the notable exception of an 82% increase in somnolence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

90.

Hypertension with unsatisfactory sleep health (HUSH): study protocol for a randomized controlled trial.

Author: LevensonJessica C, RollmanBruce L, RitterbandLee M, StrolloPatrick J, SmithKenneth J, YabesJonathan G, MooreCharity G, HarveyAllison G, BuysseDaniel J

Insomnia is common and while behavioral therapies are recommended for treatment, they are not readily available. This study is evaluating two different cognitive behavioral therapies for insomnia (BBTI and SHUTi) against a standard care approach. The study aims to assess the effectiveness of these therapies and their impact on other health conditions.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

91.

Three-Year Follow-Up Comparing Cognitive Behavioral Therapy for Depression to Cognitive Behavioral Therapy for Insomnia, for Patients With Both Diagnoses.

Author: BlomKerstin, JernelövSusanna, RückChristian, LindeforsNils, KaldoViktor

Depression severity reduction
Insomnia treatment

This 3-year follow-up study compared insomnia treatment to depression treatment for patients with both diagnoses. The results showed that after 3 years, insomnia treatment had superior effects on insomnia severity compared to depression treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

92.

Improvements of adolescent psychopathology after insomnia treatment: results from a randomized controlled trial over 1 year.

Author: de BruinEduard J, BögelsSusan M, OortFrans J, MeijerAnne Marie

CBTI
Adolescent insomnia

This study investigated the effectiveness of cognitive behavioral therapy for insomnia (CBTI) in improving psychopathology in adolescents, comparing internet-based and face-to-face group treatment to a waitlist control.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

93.

Sleep hygiene education as a treatment of insomnia: a systematic review and meta-analysis.

Author: ChungKa-Fai, LeeChit-Tat, YeungWing-Fai, ChanMan-Sum, ChungEmily Wing-Yue, LinWai-Ling

Improved Sleep

This systematic review assessed the efficacy of sleep hygiene education (SHE) for poor sleep or insomnia. Although SHE is less effective than cognitive-behavioural therapy for insomnia (CBT-I), unanswered methodological and implementation issues prevent a firm conclusion to be made on whether SHE has a role in a stepped-care model for insomnia in primary care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Cognitive Behavioural Therapy for Insomnia (CBT-I) to treat depression: A systematic review.

Author: CunninghamJasmyn E A, ShapiroColin M

Improved sleep
Reduced depression

Cognitive Behavioural Therapy for Insomnia (CBT-I) may be effective in treating sleep and circadian disturbances associated with depression, potentially serving as a stand-alone treatment for depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

Does online insomnia treatment reduce depressive symptoms? A randomized controlled trial in individuals with both insomnia and depressive symptoms.

Author: van der ZweerdeT, van StratenA, EfftingM, KyleS D, LanceeJ

Improved insomnia
Reduced depressive symptoms

Guided online CBT-I was effective in treating both insomnia and depressive symptoms in participants with clinical insomnia and at least subclinical depression levels, with effects comparable to depression therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

96.

Antidepressants for insomnia in adults.

Author: EverittHazel, BaldwinDavid S, StuartBeth, LipinskaGosia, MayersAndrew, MaliziaAndrea L, MansonChristopher Cf, WilsonSue

Hypnotic medications
Insomnia treatment
Dependence
Tolerance

Insomnia is a common condition that affects sleep quality and can lead to problems with mood, substance use, and overall health. While sleep medications are used, they can cause tolerance and dependence, and many people take them long-term. Antidepressants are also used for insomnia, but there's no strong evidence to support their effectiveness. This may be due to concerns about long-term use of sleep medications and limited access to psychological treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Effect of insomnia treatments on depression: A systematic review and meta-analysis.

Author: GebaraMarie Anne, SiripongNalyn, DiNapoliElizabeth A, MareeRachel D, GermainAnne, ReynoldsCharles F, KasckowJohn W, WeissPatricia M, KarpJordan F

Improved depression

A systematic review and meta-analysis found that treatment of insomnia may lead to improvements in depression outcomes in individuals with both insomnia and depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

Impact of group treatment for insomnia on daytime symptomatology: Analyses from a randomized controlled trial in primary care.

Author: SandlundChristina, HettaJerker, NilssonGunnar H, EkstedtMirjam, WestmanJeanette

Improved fatigue
Improved mood
Improved quality of life
Unknown risks

Nurse-led group treatment based on CBT-I improved many aspects of daytime symptomatology in primary care patients with insomnia. The treatment showed improvement in fatigue, mood, health-related quality of life, general daytime functioning, specific daytime symptoms, and dysfunctional beliefs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

99.

Acupressure for insomnia: A protocol for systematic review and meta-analysis.

Author: WuDong-Jie, DongHai-Cheng, TangTsz-Nga, ZhuShi-Feng

Potential for insomnia therapy

This systematic review will assess the effectiveness of acupressure as a treatment for insomnia. The review will include randomized clinical trials of acupressure and auricular acupuncture for insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

100.

Cognitive behavioral treatments for insomnia and pain in adults with comorbid chronic insomnia and fibromyalgia: clinical outcomes from the SPIN randomized controlled trial.

Author: McCraeChristina S, WilliamsJacob, RoditiDaniela, AndersonRyan, MundtJennifer M, MillerMary Beth, CurtisAshley F, WaxenbergLori B, StaudRoland, BerryRichard B, RobinsonMichael E

Improved insomnia symptoms
Reduced pain

CBT-I and CBT-P improved self-reported insomnia symptoms in patients with comorbid fibromyalgia and insomnia. CBT-I prompted larger improvements, which were maintained at 6 months. Both treatments prompted clinically meaningful, immediate pain reductions in one third of patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

101.

The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia.

Author: BrooksSander, JacobsGabriël E, de BoerPeter, KentJustine M, Van NuetenLuc, van AmerongenGuido, ZuikerRob, KezicIva, LuthringerRemy, van der ArkPeter, van GervenJoop Ma, DrevetsWayne

Insomnia treatment
Insomnia in depression

Insomnia is common in patients with major depressive disorder, and often persists despite antidepressants improving mood. The orexin-2 receptor is a new target for the treatment of persistent insomnia in major depressive disorder.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

102.

Non-pharmacological and pharmacological interventions relieve insomnia symptoms by modulating a shared network: A controlled longitudinal study.

Author: FengFen, YuSiyi, WangZhengyan, WangJialin, ParkJoel, WilsonGeorgia, DengMou, HuYouping, YanBohua, KongJian

PI treatment

Primary insomnia is a common sleep problem. While treatments, including medications and behavioral therapy, are effective, it's unclear how they work. This study aims to investigate and compare the mechanisms underlying different insomnia treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

103.

Efficacy of individualized homeopathic treatment of insomnia: Double-blind, randomized, placebo-controlled clinical trial.

Author: MichaelJames, SinghSubhas, SadhukhanSatarupa, NathArunava, KunduNivedita, MagotraNitin, DuttaSusmit, ParewaManeet, KoleyMunmun, SahaSubhranil

Sleep improvement

Individualized homeopathy was more effective than placebo in treating insomnia. Further research with larger samples and independent replications is needed to confirm these findings.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

104.

Effectiveness of Internet-Delivered Computerized Cognitive Behavioral Therapy for Patients With Insomnia Who Remain Symptomatic Following Pharmacotherapy: Randomized Controlled Exploratory Trial.

Author: SatoDaisuke, YoshinagaNaoki, NagaiEiichi, NagaiKazue, ShimizuEiji

Insomnia improvement
No side effects reported

Internet-delivered computerized cognitive behavioral therapy (ICBT) is an effective adjunct to usual care for improving insomnia and related symptoms in patients who remain symptomatic following hypnotics. The adjusted mean reduction in the Pittsburgh Sleep Quality Index (PSQI) at week 6 was significantly larger in the ICBT plus usual care group (-6.11) than in the usual care alone group (0.40).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

105.

Acupuncture Versus Cognitive Behavioral Therapy for Insomnia in Cancer Survivors: A Randomized Clinical Trial.

Author: GarlandSheila N, XieSharon X, DuHamelKate, BaoTing, LiQing, BargFrances K, SongSarah, KantoffPhilip, GehrmanPhilip, MaoJun J

Improved insomnia treatment

This study compares the effectiveness of acupuncture and Cognitive Behavioral Therapy for Insomnia (CBT-I) for managing insomnia in cancer survivors, who often prefer nonpharmacological treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

106.

Cognitive behavioural treatment for insomnia in primary care: a systematic review of sleep outcomes.

Author: DavidsonJudith R, DicksonCiara, HanHan

CBT-I
Chronic insomnia treatment

While cognitive behavioral therapy for insomnia (CBT-I) is recommended as the first treatment for chronic insomnia, research on its effectiveness in primary care settings is limited. This study aims to assess the effectiveness of CBT-I for chronic insomnia in real-world settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

107.

Cognitive and behavioral therapy for insomnia increases the use of continuous positive airway pressure therapy in obstructive sleep apnea participants with comorbid insomnia: a randomized clinical trial.

Author: SweetmanAlexander, LackLeon, CatchesidePeter G, AnticNick A, SmithSimon, Chai-CoetzerChing Li, DouglasJames, O'gradyAmanda, DunnNicola, RobinsonJan, PaulDenzil, WilliamsonPaul, McEvoyR Doug

Improved sleep
Increased CPAP use

This study tested the hypothesis that initial treatment with cognitive and behavioral therapy for insomnia (CBT-i), versus treatment as usual (TAU) would improve insomnia symptoms and increase subsequent acceptance and use of CPAP in participants with OSA and co-occurring insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

108.

A randomized controlled trial comparing guided internet-based multi-component treatment and internet-based guided sleep restriction treatment to care as usual in insomnia.

Author: KriegerTobias, UrechAntoine, DussSimone B, BlättlerLarissa, SchmittWolfgang, GastHeidemarie, BassettiClaudio, BergerThomas

Improved quality of life
Improved sleep quality
Reduced depressive symptoms
Reduced insomnia severity
None

Both multi-component cognitive behavioral self-help intervention (MCT) and sleep restriction intervention for insomnia (SRT) were more effective than care as usual (CAU) for insomnia at 8 weeks, with medium to large effect sizes on primary outcome and small to medium effect sizes on secondary outcomes. Treatment gains were maintained at 6-month follow-up. There was no statistical difference between MCT and SRT, but participants in MCT were significantly more satisfied with the intervention.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

109.

Effectiveness and safety of acupuncture for insomnia: Protocol for a systematic review.

Author: ZhangMingming, ZhaoJingwei, LiXiao, ChenXinwang, XieJin, MengLingyan, GaoXiyan

Improved insomnia treatment

Acupuncture has been shown to be effective in treating insomnia. This study aims to evaluate its efficacy and safety, providing evidence for clinical application.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

110.

Effect of Transcranial Alternating Current Stimulation for the Treatment of Chronic Insomnia: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Clinical Trial.

Author: WangHong-Xing, WangLi, ZhangWen-Rui, XueQing, PengMao, SunZhi-Chao, LiLi-Ping, WangKun, YangXiao-Tong, JiaYu, ZhouQi-Lin, XuZhe-Xue, LiNing, DongKai, ZhangQian, SongHai-Qing, ZhanShu-Qin, MinBao-Quan, FanChun-Qiu, ZhouAi-Hong, GuoXiu-Hua, LiHai-Bin, LiangLi-Rong, YinLu, SiTian-Mei, HuangJing, YanTian-Yi, CosciFiammetta, KamiyaAtsushi, LuJie, WangYu-Ping

Improved insomnia
Safe treatment

This study found that transcranial alternating current stimulation (tACS) may be an effective and safe intervention for chronic insomnia. The active group showed a statistically significant decrease in PSQI total score, a shortened SOL, an increased TST, improved sleep efficiency, and improved sleep quality compared to the sham group. No adverse events or serious adverse responses occurred during the study.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

111.

The effect of cognitive and behavioral therapy for insomnia on week-to-week changes in sleepiness and sleep parameters in patients with comorbid insomnia and sleep apnea: a randomized controlled trial.

Author: SweetmanAlexander, McEvoyR Doug, SmithSimon, CatchesidePeter G, AnticNick A, Chai-CoetzerChing Li, DouglasJames, O'GradyAmanda, DunnNicola, RobinsonJan, PaulDenzil, WilliamsonPaul, LackLeon

CBTi
Daytime sleepiness

This study investigates the impact of obstructive sleep apnea (OSA) severity and daytime sleepiness on the effectiveness of cognitive and behavioral therapy for insomnia (CBTi), examining whether CBTi can worsen daytime sleepiness in patients with severe OSA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

112.

Risk of excessive sleepiness in sleep restriction therapy and cognitive behavioral therapy for insomnia: a randomized controlled trial.

Author: ChengPhilip, KalmbachDavid, Fellman-CoutureCynthia, ArnedtJ Todd, Cuamatzi-CastelanAndrea, DrakeChristopher L

Sleep improvement
Sleepiness risk

Sleep restriction therapy (SRT) appears to be a viable alternative to cognitive behavioral therapy for insomnia (CBT-I) in postmenopausal women, with comparable effectiveness but lower patient contact requirements. However, further research is needed to determine if SRT increases sleepiness as much as CBT-I.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

113.

Examining sleep over time in a randomized control trial comparing two integrated PTSD and alcohol use disorder treatments.

Author: ColvonenPeter J, StrausLaura D, DrummondSean P A, AngkawAbigail C, NormanSonya B

This study examines how insomnia changes over time in a randomized controlled trial of two integrated treatments for posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

114.

Nurse-Guided Internet-Delivered Cognitive Behavioral Therapy for Insomnia in General Practice: Results from a Pragmatic Randomized Clinical Trial.

Author: Van der ZweerdeTanja, LanceeJaap, SlottjePauline, BosmansJudith E, Van SomerenEus J W, van StratenAnnemieke

Improves sleep quality
Reduces insomnia severity

Nurse-guided Internet-delivered CBT-I (I-CBT-I) effectively reduces insomnia severity among general practice patients. I-CBT-I enables general practitioners to offer effective insomnia care in accordance with the clinical guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

115.

A randomized controlled trial of CBT-I and PAP for obstructive sleep apnea and comorbid insomnia: main outcomes from the MATRICS study.

Author: OngJason C, CrawfordMegan R, DawsonSpencer C, FoggLouis F, TurnerArlener D, WyattJames K, CrisostomoMaria I, ChhanganiBantu S, KushidaClete A, EdingerJack D, AbbottSabra M, MalkaniRoneil G, AttarianHrayr P, ZeePhyllis C

Improved insomnia

A study of 121 adults with OSA and comorbid insomnia found that combining CBT-I with PAP was superior to PAP alone on insomnia outcomes. However, the combination did not significantly improve PAP adherence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

116.

A randomized phase II trial evaluating two non-pharmacologic interventions in cancer survivors for the treatment of sleep-wake disturbances: NCCTG N07C4 (Alliance).

Author: BartonDebra L, AthertonPamela J, SateleDaniel V, QinRui, DakhilShaker, PipeTeri, HobdayTimothy, Fee-SchroederKelli, LoprinziCharles L

Improved sleep

A home-based sleep intervention based on cognitive behavioral therapy for insomnia (CBT-I) was evaluated in 93 cancer survivors with sleep difficulties. Both the intervention group (sleep hygiene, stimulus control, sleep restriction, bedtime imagery) and the control group (similar to intervention but without sleep restriction and using bedtime stories) showed improvement in sleep outcomes, but no significant difference was found between the groups. This study supports the effectiveness of CBT-I for sleep, but suggests that better delivery methods are needed to improve uptake and effect size.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

117.

Melatonin and melatonin agonists as treatments for benzodiazepines and hypnotics withdrawal in patients with primary insomnia. A systematic review.

Author: Morera-FumeroArmando L, Fernandez-LopezLourdes, Abreu-GonzalezPedro

Benzodiazepine/hypnotic discontinuation
Insomnia treatment
None reported

Melatonin is an effective treatment for the discontinuation of benzodiazepines and hypnotics in patients with primary insomnia. It can also help reduce consumption in patients who cannot fully discontinue these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

118.

Experience of Treatment and Adherence to Cognitive Behavioral Therapy for Insomnia for Patients with Depression: An Interview Study.

Author: DyrbergHenny, JuelAnette, KraghMette

Improved insomnia treatment

This study explores how patients with depression experience and adhere to Cognitive Behavioral Therapy for Insomnia (CBT-I), highlighting the importance of understanding patient experiences for effective treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

119.

The efficacy of cognitive and behavior therapies for insomnia on daytime symptoms: A systematic review and network meta-analysis.

Author: BenzFee, KnoopTeresa, BallesioAndrea, BacaroValeria, JohannAnna F, RückerGerta, FeigeBernd, RiemannDieter, BaglioniChiara

Daytime symptom improvement
Insomnia treatment

Cognitive and behavioral therapies for insomnia (CBT-I) are effective in treating daytime symptoms associated with insomnia disorder. While the effects on core insomnia symptoms are stronger, CBT-I demonstrably improves depressive symptoms, anxiety, daytime sleepiness, fatigue, quality of life, and other daytime impairments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

120.

Effects of trazodone versus cognitive behavioral therapy in the insomnia with short sleep duration phenotype: a preliminary study.

Author: VgontzasAlexandros N, PuzinoKristina, Fernandez-MendozaJulio, KrishnamurthyVenkatesh Basappa, BastaMaria, BixlerEdward O

Improved insomnia treatment

This study investigates whether insomnia with objective short sleep duration responds better to pharmacological treatment than cognitive behavioral therapy for insomnia (CBT-I).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

121.

Objective sleep disturbance is associated with poor response to cognitive and behavioral treatments for insomnia in postmenopausal women.

Author: KalmbachDavid A, ChengPhilip, RothThomas, SagongChaewon, DrakeChristopher L

Insomnia treatment

This study aims to determine whether insomnia patients with objective sleep disturbance respond differently to cognitive and behavioral treatments compared to those without such disturbance. It also investigates the impact of insomnia therapy on objective sleep and the relationship between reductions in nocturnal cognitive arousal and changes in objective sleep.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

122.

Cannabinoids in the Treatment of Insomnia Disorder: A Systematic Review and Meta-Analysis.

Author: BhagavanChiranth, KungStacey, DoppenMarjan, JohnMary, VakalalabureIva, OldfieldKaren, BraithwaiteIrene, Newton-HowesGiles

Insomnia treatment

This systematic review and meta-analysis evaluated the efficacy of cannabinoids in the treatment of insomnia disorder. The study found that, despite some possible signals for efficacy, the heterogeneity of participants, interventions, efficacy outcomes and results, and the high risk of bias across included trials, do not reliably inform evidence-based practice. Further high-quality RCTs are required before drawing any conclusions about the efficacy of cannabinoids in the treatment of insomnia disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

123.

Reducing Barriers to Behavioral Treatments for Insomnia: A Qualitative Examination of Veterans' Perspectives of BBTI.

Author: HolderNicholas, KanadyJennifer C, StrausLaura D, KhanAmanda J, PurcellNatalie, HugginsJoy, GloriaRebecca, NeylanThomas C, LujanCallan, MaguenShira

Insomnia treatment

This qualitative study examines the experiences of veterans with insomnia disorder participating in Brief Behavioral Treatment for Insomnia (BBTI). The study found that BBTI was successful in overcoming barriers to behavioral insomnia treatment and identified key treatment aspects that should be maintained to preserve acceptability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

124.

Effect of Telephone Cognitive Behavioral Therapy for Insomnia in Older Adults With Osteoarthritis Pain: A Randomized Clinical Trial.

Author: McCurrySusan M, ZhuWeiwei, Von KorffMichael, WellmanRobert, MorinCharles M, ThakralManu, YeungKai, VitielloMichael V

Improved sleep
Reduced fatigue
Reduced pain

Telephone cognitive behavioral therapy for insomnia (CBT-I) was effective in improving sleep, fatigue, and pain among older adults with comorbid insomnia and osteoarthritis pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

126.

Insomnia treatment effects among young adult drinkers: Secondary outcomes of a randomized pilot trial.

Author: MillerMary Beth, FreemanLindsey, ParkChan Jeong, HallNicole A, DerocheChelsea, SahotaPradeep K, McCraeChristina S

Improved emotion regulation
Improved insomnia
Reduced alcohol craving

Cognitive behavioral therapy for insomnia has moderate-to-large effects on insomnia among young adult drinkers and may improve alcohol-related consequences.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

127.

[The dynamics of sleep quality in patients with chronic insomnia during the complex spa treatment with the inclusion of transcranial magnetic therapy].

Author: GoryaevA G, KulishovaT V

Insomnia treatment

Many people (45%) are unhappy with their sleep, and chronic insomnia is a common sleep problem, affecting 9-15% of people. Insomnia can negatively impact social life, work, and overall health. It's clear that accurate diagnosis and effective treatment are important for insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

128.

Effects of Mindfulness-Based Relapse Prevention on the Chronic use of Hypnotics in Treatment-Seeking Women with Insomnia: a Randomized Controlled Trial.

Author: BarrosViviam Vargas, OpaleyeEmérita Sátiro, DemarzoMarcelo, CuradoDaniela Fernández, BowenSarah, HachulHelena, NotoAna Regina

Mindfulness for hypnotic use
Hypnotic dependence

Mindfulness-based interventions (MBIs) may help reduce or cease chronic hypnotic use among women with insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

129.

Mindfulness-based therapy for insomnia for older adults with sleep difficulties: a randomized clinical trial.

Author: PeriniFrancesca, WongKian Foong, LinJia, HassirimZuriel, OngJu Lynn, LoJune, OngJason C, DoshiKinjal, LimJulian

MBTI for insomnia
SHEEP for insomnia

Mindfulness-Based Therapy for Insomnia (MBTI) and a Sleep Hygiene, Education, and Exercise Program (SHEEP) were compared in older adults with poor sleep. Both interventions showed improvements in subjective and objective sleep outcomes.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

130.

Randomized Noninferiority Trial of Telehealth Delivery of Cognitive Behavioral Treatment of Insomnia Compared to In-Person Care.

Author: GehrmanPhilip, GunterPaul, FindleyJames, FrassoRosemarie, WeljieAalim M, KunaSamuel T, KayserMatthew S

CBT-I effectiveness
Insomnia treatment

This study compared the efficacy of CBT-I delivered by telehealth to in-person treatment and to a waitlist control. Insomnia is prevalent and is associated with a range of negative sequelae. Cognitive behavioral treatment for insomnia (CBT-I) is the recommended intervention, but availability is limited. Telehealth provides increased access, but its efficacy is not certain.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

131.

Association between insomnia patients' pre-treatment characteristics and their responses to distinctive treatment sequences.

Author: EdingerJack D, Beaulieu-BonneauSimon, IversHans, GuayBernard, BélangerLynda, SimmonsBryan, MorinCharles M

Insomnia treatment

This study aims to identify factors that might help predict which treatment approach for insomnia is most likely to be effective for individual patients. The researchers will examine whether certain characteristics or traits can help determine the best sequence of treatments for people with insomnia who haven't responded well to initial treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

133.

Effectiveness of Unguided Internet-Based Cognitive Behavioral Therapy and the Three Good Things Exercise for Insomnia: 3-Arm Randomized Controlled Trial.

Author: SatoDaisuke, SekizawaYoichi, SutohChihiro, HiranoYoshiyuki, OkawaSho, HiroseMotohisa, TakemuraRyo, ShimizuEiji

Insomnia improvement

This study compared the effectiveness of unguided internet-based cognitive behavioral therapy (ICBT) and the Three Good Things (TGT) exercise for improving insomnia symptoms compared to a waiting list control group. Both ICBT and TGT showed significant improvement in insomnia symptoms after 4 weeks compared to the control group. ICBT showed greater improvement in multiple sleep parameters, including sleep onset latency, total sleep time, and Athens Insomnia Scale score, at both 4 and 8 weeks. These findings suggest that unguided online interventions can effectively improve insomnia symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

134.

The effects of digital CBT-I on work productivity and activity levels and the mediational role of insomnia symptoms: Data from a randomized controlled trial with 6-month follow-up.

Author: KjørstadKaia, SivertsenBørge, VedaaØystein, LangsrudKnut, VetheDaniel, FaalandPatrick M, VestergaardCecilie L, LydersenStian, SmithOtto R F, ScottJan, KallestadHåvard

Reduced Impairment
None

This randomized controlled trial compared the efficacy of digital cognitive behavioral therapy for insomnia (dCBT-I) with patient education in improving insomnia and reducing work and activity impairment. dCBT-I was associated with reduced activity impairment and mediated improvements in presenteeism and activity impairment through reductions in insomnia severity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

135.

Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis.

Author: De CrescenzoFranco, D'AlòGian Loreto, OstinelliEdoardo G, CiabattiniMarco, Di FrancoValeria, WatanabeNorio, KurtulmusAyse, TomlinsonAnneka, MitrovaZuzana, FotiFrancesca, Del GiovaneCinzia, QuestedDigby J, CowenPhil J, BarbuiCorrado, AmatoLaura, EfthimiouOrestis, CiprianiAndrea

Pharmacological treatments for insomnia

This study aimed to compare the effectiveness of different pharmacological treatments for insomnia in adults. While behavioral, cognitive, and pharmacological interventions are effective for insomnia, medications are more widely used due to resource limitations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

136.

The Sleep, Cancer and Rest (SleepCaRe) Trial: Rationale and design of a randomized, controlled trial of cognitive behavioral and bright light therapy for insomnia and fatigue in women with breast cancer receiving chemotherapy.

Author: MaccoraJordan, GarlandSheila N, FtanouMaria, DayDaphne, WhiteMichelle, LopezVeronica Aedo, MortimerDuncan, DiggensJustine, PhillipsAndrew J K, WallaceRebecca, AlexanderMarliese, BoyleFrances, StaffordLesley, FrancisPrudence A, BeiBei, WileyJoshua F

Improved sleep quality

Insomnia and fatigue are common in breast cancer patients, particularly during active cancer treatment. Sleep disturbances are often overlooked and undertreated in routine cancer care. This study suggests that brief cognitive behavioral therapy for Insomnia (CBTI) and bright light therapy (BLT) may offer accessible and effective sleep treatments for women receiving chemotherapy for breast cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

137.

Treatment Fidelity in a Randomized Controlled Trial of Cognitive Behavioral Therapy for Insomnia in Heart Failure.

Author: O'ConnellMeghan, DeSanto IennacoJoanne, LinskySarah, JeonSangchoon, ConleySamantha, GaiserEdward, RedekerNancy S

CBT-I benefits
Insomnia relief

This study examined the effectiveness of cognitive behavioral therapy for insomnia (CBT-I) in people with heart failure (HF). The study found that most participants completed the CBT-I intervention and followed the treatment plan. CBT-I resulted in a significant decrease in actigraph-measured light intensity during the 30 minutes and 1 hour before bedtime, and most participants reported using strategies to improve their sleep schedules. The results suggest that CBT-I may be an effective treatment for insomnia in people with HF.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

138.

A comparison of cognitive behavioral therapy for insomnia to standard of care in an outpatient substance use disorder clinic embedded within a therapeutic community: a RE-AIM framework evaluation.

Author: SpeedTraci J, HanksLisa, TurnerGavin, GuruleEvelyn, KearsonAlexandra, BuenaverLuis, SmithMichael T, AntoineDenis

Insomnia treatment
SUD recovery

This study investigated the potential of cognitive-behavioral therapy for insomnia (CBT-I) in helping individuals who recently entered an outpatient SUD treatment program within a therapeutic community.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

139.

Is Cognitive Behavioral Therapy for Insomnia Effective for Improving Sleep Duration in Individuals with Insomnia? A Meta-Analysis of Randomized Controlled Trials.

Author: ChanWai Sze, McCraeChristina S, NgAlbe Sin-Ying

Insomnia treatment
Sleep duration

This review explored the evidence for the effectiveness of CBT-I in increasing sleep duration for individuals with chronic insomnia, considering the importance of sleep duration for overall health.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

140.

Zopiclone versus placebo for short-term treatment of insomnia in patients with advanced cancer-a double-blind, randomized placebo-controlled clinical multicenter phase IV trial.

Author: JakobsenGunnhild, SjueKarin, PaulsenØrnulf, KaasaStein, HjermstadMarianne Jensen, KlepstadPål

Sleep improvement

This study examines the short-term effectiveness of zopiclone on sleep quality in patients with advanced cancer experiencing insomnia, as there is a lack of comprehensive research on pharmacological sleep therapies in this patient group.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

141.

Twelve-month follow-up: Comparative efficacy of cognitive therapy, behavior therapy, and cognitive behavior therapy for patients with insomnia.

Author: SarfanLaurel D, MorinCharles M, HarveyAllison G

Improved insomnia
Improved mental health
Improved sleep efficiency
Improved sleep onset latency
Improved total sleep time
Improved wake after sleep onset
Improved work and social adjustment

Cognitive therapy (CT), behavior therapy (BT), and cognitive behavior therapy (CBT) were all effective in improving insomnia symptoms over the long term. CBT showed a relative advantage for some outcomes and subgroups.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

142.

A randomized trial to evaluate the effects of a supervised exercise program on insomnia in patients with non-metastatic breast cancer undergoing chemotherapy: design of the FATSOMCAN study.

Author: DrozdChloé, CurtitElsa, JacquinotQuentin, MarquineCharlène, MansiLaura, ChaigneauLoïc, DobiErion, ViotJulien, MeynardGuillaume, PaillardMarie-Justine, GoujonMorgan, RouxPauline, VernereyDewi, GilletValérie, BourdinHubert, GalliSilvio, MeneveauNathalie, MouginFabienne

Insomnia management in breast cancer patients

Up to 70% of breast cancer patients report symptoms of insomnia during and after treatment. While sleep medications treat symptoms, they are ineffective to cure insomnia. This study examines the potential of an aerobic exercise program as a feasible and promising treatment for insomnia management in breast cancer patients.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

143.

Effect of Cognitive Behavioral Therapy for Insomnia on Alcohol Treatment Outcomes Among US Veterans: A Randomized Clinical Trial.

Author: MillerMary Beth, CarpenterRyan W, FreemanLindsey K, DunsigerShira, McGearyJohn E, BorsariBrian, McCraeChristina S, ArnedtJ Todd, KortePaul, MerrillJennifer E, CareyKate B, MetrikJane

Improved sleep
Reduced alcohol use
None reported

Cognitive behavioral therapy for insomnia (CBT-I) was more effective than sleep hygiene in reducing insomnia symptoms and alcohol-related problems in veterans early in their alcohol use disorder (AUD) treatment. CBT-I participants reported greater decreases in insomnia severity at posttreatment (group × time interaction: -3.70; 95% CI, -6.79 to -0.61) and follow-up (-3.34; 95% CI, -6.46 to -0.23) and greater improvements in sleep efficiency (posttreatment, 8.31; 95% CI, 1.35 to 15.26; follow-up, 18.03; 95% CI, 10.46 to 25.60). CBT-I should be considered a first-line treatment for insomnia in AUD regardless of abstinence.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

144.

A non-inferiority randomized controlled trial comparing behavioral sleep interventions in women veterans: An examination of pain outcomes.

Author: RavytsScott G, EricksonAlexander J, WashingtonDonna L, YanoElizabeth M, CarlsonGwendolyn C, MitchellMichael N, KellyMonica, AlessiCathy A, McGowanSarah Kate, SongYeonsu, MartinJennifer L, DzierzewskiJoseph M

Reduced pain symptoms

Both cognitive behavioral therapy for insomnia (CBTI) and acceptance and behavioral changes for insomnia (ABC-I) were found to be effective in reducing insomnia symptoms in individuals with comorbid pain.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

145.

The Relationship of Early Sleep Improvement With Response to Pharmacotherapy in Unipolar Psychotic Depression.

Author: VosCornelis F, BirkenhägerTom K, NolenWillem A, van den BroekWalter W, Ter HarkSophie E, SchellekensArnt F A, VerkesRobbert-Jan, JanzingJoost G E

Improved treatment outcome

This study investigated whether early insomnia improvement (EII) predicted treatment outcome in psychotic depression (PD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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