Paper Details

  1. Home
  2. Paper Details

Rapid development of tolerance to the antihypertensive effect of nisoldipine.

Author: RamsayL E, WallerP C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Nisoldipine lowered blood pressure, but tolerance to its antihypertensive effect developed rapidly.
Paper Details　
Original Abstract of the Article :
Antihypertensive efficacy and tolerability of the dihydropyridine calcium antagonist nisoldipine were examined in a double-blind, placebo-controlled study. Twenty patients with hypertension (greater than 140/95 mmHg) uncontrolled by bendrofluazide plus atenolol were randomly allocated to receive nis...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/3065506

データ提供：米国国立医学図書館（NLM）

The Tale of the Diminishing Effect: Nisoldipine and Blood Pressure Control

The journey to [blood pressure control] is often paved with challenges, and [nisoldipine], a [dihydropyridine calcium antagonist], is no exception. This study explores the efficacy and tolerability of [nisoldipine] in patients with [hypertension]. The researchers found that [nisoldipine] effectively lowered [blood pressure] initially, but this effect gradually diminished over time.

The study revealed a phenomenon known as [tolerance] to the antihypertensive effects of [nisoldipine]. This is like a camel's ability to adapt to the harsh desert environment, initially finding relief from the heat but gradually becoming accustomed to it. The researchers observed a significant decline in the drug's effectiveness after just a few weeks.

A Shifting Landscape: Blood Pressure Control and Drug Tolerance

The study highlights the importance of considering the potential for [tolerance] when using certain [antihypertensive] medications. This phenomenon can lead to reduced efficacy over time and may require adjustments to treatment strategies.

Navigating the Tides of Blood Pressure: Understanding Tolerance

It is essential to be aware of the potential for [tolerance] to develop with certain medications. This knowledge can help patients and healthcare providers adjust treatment plans as needed.

Dr.Camel's Conclusion

This study underscores the dynamic nature of [blood pressure control] and the importance of staying vigilant about potential [tolerance] to medications. Like a camel navigating the changing tides of the desert, we must adapt our strategies to maintain our health and well-being.

Date :
  1. Date Completed 1989-03-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3065506

DOI: Digital Object Identifier

3065506

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.