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Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.

Author: BaumgartnerLisa, GalenoGianluca, GoodAndrin, GoodNicolas, HlavicaMartin, HooijmansCarlijn R, IneichenBenjamin V, JungTarzis, SchneiderMarc P, SchulerFlorian A F, de VriesRob

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study reviewed 88 different potential treatments for repairing the myelin sheath, which is damaged in multiple sclerosis (MS). 25 of these treatments have progressed to human clinical trials. The review identified 16 promising treatments that haven't yet been tested in humans, including Pigment epithelium-derived factor, Platelet-derived growth factor, and Tocopherol derivative TFA-12. The study also found that the quality of research in animal models can impact the translation of treatments into human trials, suggesting that improvements in research methods could lead to more successful treatments.
Paper Details　
Original Abstract of the Article :
An unmet but urgent medical need is the development of myelin repair promoting therapies for Multiple Sclerosis (MS). Many such therapies have been pre-clinically tested using different models of toxic demyelination such as cuprizone, ethidium bromide, or lysolecithin and some of the therapies alrea...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351564/

データ提供：米国国立医学図書館（NLM）

Remyelination: Seeking Oasis in the Desert of Multiple Sclerosis

Multiple Sclerosis (MS) is a challenging condition, like traversing a vast and unforgiving desert. It’s a disease that can leave you feeling lost and isolated, with the relentless attacks on myelin, the protective sheath around nerve fibers. This research delves into the search for remyelination therapies, seeking to restore the damaged myelin and provide relief for those affected by MS. It’s like discovering a hidden spring in the desert, offering the promise of rejuvenation and renewal. The researchers conducted a systematic review and meta-analysis of preclinical studies examining the effectiveness of various remyelination therapies in animal models.

Emerging Oasis: A Glimpse of Hope

The researchers identified 88 different therapies that have been tested for remyelination, highlighting the vast and ever-expanding landscape of potential treatments. It’s like exploring a desert with countless hidden oases, each with unique characteristics and potential. Furthermore, the meta-analysis revealed 16 promising therapies that have yet to enter clinical trials for MS, offering a beacon of hope for future therapies. This is like discovering new oases, previously unknown, holding the promise of future discoveries and advancements.

Navigating the Path to Recovery

This research highlights the importance of preclinical studies in finding promising remyelination therapies. It’s like exploring a desert with a compass, identifying potential routes to a destination. However, the authors emphasize the need to address issues of study quality and improve the translation of successful therapies from the lab to the clinic. It’s a journey of discovery, and the authors call for collaboration and innovation to navigate the desert of MS and find effective treatments.

Dr.Camel's Conclusion

This research offers a refreshing glimpse of hope in the desert of MS, exploring the potential of remyelination therapies. It’s like finding a wellspring of knowledge in a vast and unforgiving desert, providing sustenance and hope for future discoveries. Further research is crucial to translate these promising therapies into effective treatments for patients.

Date :
  1. Date Completed 2020-08-04
  2. Date Revised 2020-08-04
Further Info :

Pubmed ID

30696832

DOI: Digital Object Identifier

PMC6351564

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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