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Extended-release naltrexone versus standard oral naltrexone versus placebo for opioid use disorder: the NEAT three-arm RCT.

Author: ByfordSarah, DayEd, HellierJennifer, KelleherMichael, MarsdenJohn, MayetSoraya, McLennanBlair, MurphyCaroline, RyanElizabeth, ShearerJames, StrangJohn

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

People recovering from heroin addiction need better treatment options. Naltrexone is a medication that blocks the effects of heroin, but the best way to take it is still being researched.
Paper Details　
Original Abstract of the Article :
People recovering from heroin addiction need better treatments than are currently offered. The chronic relapsing nature of drug dependence means that helping a patient to achieve abstinence is often difficult. Naltrexone blocks the effects of ingested heroin; however, evidence is conflicting regardi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378535/

データ提供：米国国立医学図書館（NLM）

Extended-Release Naltrexone: A Steady Stream in the Desert of Opioid Use Disorder

Opioid use disorder (OUD) is a formidable foe, akin to a vast and treacherous desert, often leading to a cycle of addiction and relapse. This study explores the potential of extended-release naltrexone as a treatment for OUD, seeking a more sustainable and effective approach to navigating this challenging terrain.

The authors conducted a three-arm randomized controlled trial, comparing extended-release naltrexone, standard oral naltrexone, and placebo. Their findings suggest that extended-release naltrexone, like a steady stream in a desert landscape, may offer a more stable and long-lasting solution for those struggling with OUD.

Extended-Release Naltrexone: A Beacon of Hope for Sustained Recovery

The study highlights the potential of extended-release naltrexone to promote sustained abstinence from opioids, like a beacon guiding individuals towards a path of recovery. This approach, like a reliable water source, offers a more predictable and consistent treatment strategy, potentially reducing the likelihood of relapse.

Navigating the Desert of Addiction: A Multifaceted Approach

While extended-release naltrexone shows promise, it is important to acknowledge that OUD is a complex and multifaceted challenge. A comprehensive approach to treatment, involving a combination of therapies, support services, and ongoing monitoring, is crucial to navigating this difficult landscape. This holistic approach, like a well-equipped desert expedition, provides the necessary tools for a successful journey towards recovery.

Dr.Camel's Conclusion

This study offers a ray of hope in the desert of OUD treatment. Extended-release naltrexone, with its potential for sustained abstinence, offers a more stable and effective approach to managing this challenging condition. As we continue to explore the vast and complex landscape of addiction, we must remain committed to finding new and innovative solutions that offer hope and support to those seeking recovery.

Date :
  1. Date Completed 2020-06-02
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

30702059

DOI: Digital Object Identifier

PMC6378535

Related Literature

Article Analysis
・Effective treatment of heroin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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