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Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial.

Author: ChlibekRoman, EspositoSusanna, FlodmarkCarl-Erik, GillardPaul, GotheforsLeif, HenryOuzama, ManSorin, PoveyMichael, PrymulaRoman, Riise BergsakerMarianne A, SilfverdalSven-Arne, UsonisVytautas, WysockiJacek, ŠtefkovičováMária

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study assesses the 10-year vaccine efficacy of two different varicella vaccination regimens: two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), and one varicella vaccine dose after one measles-mumps-rubella vaccine dose (MMR + V). The study compares the efficacy of these regimens to two doses of MMR for the prevention of confirmed varicella.
Paper Details　
Original Abstract of the Article :
The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V),...See full text at original site
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引用元：
https://doi.org/10.1016/S1473-3099(18)30716-3

データ提供：米国国立医学図書館（NLM）

Protecting Against Varicella: A Multi-Dose Approach

The human immune system is a sophisticated network of defenses, protecting us from a myriad of illnesses. This study investigates the long-term effectiveness of varicella vaccines, specifically comparing two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV) with one dose of a monovalent varicella vaccine. The researchers conducted a phase 3 multicenter randomized controlled trial to assess the 10-year vaccine efficacy against confirmed varicella. The results showed that two doses of MMRV provided significant protection against varicella over a 10-year period. This suggests that a multi-dose approach to varicella vaccination could provide longer-lasting immunity.

Multi-Dose Vaccination: A Key to Long-Term Protection

This study highlights the potential benefits of multi-dose vaccination for varicella. The long-term protection achieved with two doses of MMRV underscores the importance of adhering to recommended vaccination schedules. This approach can help to maximize the effectiveness of vaccines and provide long-lasting immunity.

Navigating the Desert of Infectious Diseases: The Importance of Vaccination

This research reinforces the importance of vaccination in protecting against infectious diseases. The long-term protection offered by MMRV provides a compelling argument for adhering to recommended vaccination schedules. Vaccination is a crucial tool for preventing the spread of diseases and safeguarding public health.

Dr.Camel's Conclusion

Two doses of MMRV provide long-term protection against varicella. This research emphasizes the importance of multi-dose vaccination strategies and the crucial role of vaccines in preventing infectious diseases.
Date :
  1. Date Completed 2020-05-25
  2. Date Revised 2020-05-25
Further Info :

Pubmed ID

30765242

DOI: Digital Object Identifier

10.1016/S1473-3099(18)30716-3

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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