Effects of high-density lipoprotein targeting treatments on cardiovascular outcomes: A systematic review and meta-analysis.

Author: KaluskiEdo, KhanSafi U, LincoffA Michael, NissenSteven E, RahmanHammad, RiazHaris, ShahNishant P

Paper Details 
Original Abstract of the Article :
BACKGROUND: The effects of increasing high-density lipoprotein cholesterol on cardiovascular outcomes remain uncertain. DESIGN: We conducted a meta-analysis to investigate the effects of high-density lipoprotein cholesterol modifiers (niacin, fibrates and cholesteryl ester transfer protein inhibito...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/30861690

データ提供:米国国立医学図書館(NLM)

The Shifting Sands of HDL Targeting Treatments: A Meta-Analysis

High-density lipoprotein (HDL), often called 'good cholesterol,' plays a crucial role in cardiovascular health. This meta-analysis examines the effects of various treatments aimed at increasing HDL levels on cardiovascular outcomes. It's like exploring a vast and complex desert, seeking to understand the intricate relationship between HDL levels and cardiovascular health.

The Quest for a Desert Oasis of Cardiovascular Health

The researchers analyzed data from 31 randomized controlled trials, encompassing a vast population of 154,601 patients. While the study found no statistically significant effect of HDL modifiers on cardiovascular mortality, stroke, or all-cause mortality, it did reveal a slight beneficial effect on myocardial infarction. It's like finding a small, hidden oasis amidst a seemingly barren landscape - a glimmer of hope, but not a complete solution.

Navigating the Uncertainties of HDL Therapy

This meta-analysis highlights the complexities of HDL therapy and the need for further research to clarify its role in preventing cardiovascular disease. It underscores the importance of a personalized approach to cardiovascular care, considering individual risk factors and tailoring treatment plans accordingly. Just as a traveler adapts to the challenges of the desert landscape, we must remain adaptable and resourceful in our approach to cardiovascular health.

Dr.Camel's Conclusion

This meta-analysis serves as a reminder that the desert of cardiovascular research is vast and complex. While the quest for a definitive solution continues, we must continue to explore new avenues and adapt our strategies based on emerging evidence. Just as a camel navigates the shifting sands, we must be prepared for the unexpected and remain open to new discoveries.

Date :
  1. Date Completed 2020-08-03
  2. Date Revised 2021-02-13
Further Info :

Pubmed ID

30861690

DOI: Digital Object Identifier

NIHMS1621088

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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