Management of adverse effects/toxicity of ibrutinib.

Author: PaydasSemra

Paper Details 
Original Abstract of the Article :
Bruton tyrosine kinase signaling (BTK) is critical step for B-cell development and immunoglobulin synthesis. Ibrutinib is an orally bioavailable bruton tyrosine kinase inhibitor (BTKi) and forms an irreversible covalent bound to BTK at the Cysteine-481 residue. Ibrutinib has been approved by FDA for...See full text at original site
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引用元:
https://doi.org/10.1016/j.critrevonc.2019.02.001

データ提供:米国国立医学図書館(NLM)

Ibrutinib: A Powerful Tool for Blood Cancer Treatment, But With Side Effects

Ibrutinib is a promising drug used to treat various types of blood cancers, including chronic lymphocytic leukemia and mantle cell lymphoma. It works by inhibiting a protein called Bruton tyrosine kinase (BTK), which plays a key role in the development and function of B-cells. This research reviews the common side effects associated with ibrutinib treatment and provides guidance for managing these adverse events. The study highlights the importance of careful monitoring and timely intervention to ensure the safety and efficacy of ibrutinib treatment.

Ibrutinib: Benefits and Side Effects

Ibrutinib has shown remarkable efficacy in treating blood cancers, but it can also cause side effects. The most common side effects are diarrhea, upper respiratory tract infections, bleeding, fatigue, and cardiac issues. While most side effects are mild, some, such as atrial fibrillation and bleeding, can be more serious and require close monitoring. This research underscores the importance of balancing the benefits and risks of ibrutinib treatment.

Managing Ibrutinib Side Effects: A Multifaceted Approach

Managing the side effects of ibrutinib requires a multifaceted approach that includes careful monitoring, timely intervention, and individualized management strategies. By understanding the potential risks and implementing appropriate interventions, healthcare providers can help patients maximize the benefits of ibrutinib treatment while minimizing the risks of adverse events. As Dr. Camel, I believe that a proactive approach to managing potential challenges is key to achieving the best possible outcomes, just as a camel prepares for the journey across the desert by ensuring its supplies and equipment are in good condition.

Dr.Camel's Conclusion

This research provides a comprehensive overview of the side effects associated with ibrutinib treatment. The study highlights the importance of careful monitoring and appropriate management strategies to ensure patient safety and maximize the efficacy of this promising treatment. As Dr. Camel, I am always mindful of the importance of understanding the potential risks and benefits of any medical intervention. This research underscores the need for a balanced approach to treatment, considering both the potential benefits and the risks involved.

Date :
  1. Date Completed 2019-04-24
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

30878129

DOI: Digital Object Identifier

10.1016/j.critrevonc.2019.02.001

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