Single dose cefoxitin in treating uncomplicated gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae (PPNG) and non-PPNG strains.

Author: LeeC T, LimK B, SngE H, TanT, ThamS N, ThirumoorthyT

Paper Details 
Original Abstract of the Article :
A total of 136 patients with uncomplicated gonorrhoea were treated with intramuscular cefoxitin 2 g (25 patients) or 1 g (111 patients) and oral probenecid 1 g. Cefoxitin 1 g cured 95% (42 out of 45 men and all of 14 women) with infections caused by penicillinase producing Neisseria gonorrhoeae (PPN...See full text at original site
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引用元:
https://doi.org/10.1136/sti.62.4.224

データ提供:米国国立医学図書館(NLM)

Fighting Gonorrhea: A Single Dose of Cefoxitin Shows Promise

The world of infectious diseases is a vast and challenging desert, constantly evolving with new threats and challenges. In this particular study, researchers focused on a single-dose treatment with cefoxitin for uncomplicated gonorrhea, a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae. This study aimed to determine the effectiveness of cefoxitin in tackling both penicillinase-producing (PPNG) and non-PPNG strains of the bacteria, using a combination of intramuscular cefoxitin and oral probenecid.

Their research revealed some encouraging findings. The study participants, 136 individuals, were treated with varying doses of cefoxitin and probenecid. The results showed that a single 1-gram dose of cefoxitin cured 95% of patients infected with PPNG strains and 98% of those infected with non-PPNG strains, leading to an impressive overall cure rate of 96%. This finding is like a refreshing oasis in the desert of infectious diseases, offering a potential solution to a widespread health concern.

A Single Dose: Hopeful Outcomes for Gonorrhea

These results suggest that a single dose of cefoxitin could be a valuable tool in the fight against gonorrhea, especially in regions where PPNG strains are prevalent. It's important to remember that the study also reported a 7% failure rate in men infected with PPNG strains who received the 1-gram dose. This highlights the importance of further research and careful monitoring to ensure the most effective treatment strategies.

Navigating the Desert of Gonorrhea: A Reminder of Prevention

The study emphasizes that while a single-dose treatment with cefoxitin shows promising results, it's not a cure-all. Just as a traveler in the desert must be prepared with supplies and knowledge, individuals should prioritize preventive measures like safe sex practices and regular testing to avoid contracting gonorrhea in the first place.

Dr. Camel's Conclusion

The study's findings offer a glimmer of hope for a more effective treatment of gonorrhea. However, like a desert oasis, this solution needs to be carefully managed and nurtured to ensure its effectiveness. We must remain vigilant in the fight against gonorrhea and continue seeking ways to improve treatment strategies and emphasize the importance of prevention.

Date :
  1. Date Completed 1986-09-25
  2. Date Revised 2019-05-03
Further Info :

Pubmed ID

3089907

DOI: Digital Object Identifier

10.1136/sti.62.4.224

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PICO Info
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Languages

English

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