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Pharmacokinetic correlates of venlafaxine: associated adverse reactions.

Author: EndresKatharina, GründerGerhard, HaenEkkehard, HiemkeChristoph, PaulzenMichael, RiddersFlorian, SchoretsanitisGeorgios, VeselinovicTanja

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the correlation between plasma concentrations of venlafaxine, its active metabolite, and adverse drug reactions in a large naturalistic sample of patients. The results did not reveal a direct link between venlafaxine metabolism measures and ADRs, suggesting the need for further research to understand the factors contributing to ADRs in patients receiving venlafaxine.
Paper Details　
Original Abstract of the Article :
To address the potential correlation between plasma concentrations of venlafaxine (VEN), its active metabolite O-desmethylvenlafaxine (ODVEN) and the active moiety, AM, (ODVEN + VEN) and adverse drug reactions (ADR) in a large naturalistic sample of in- and outpatients. We compared plasma concentrat...See full text at original site
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引用元：
https://doi.org/10.1007/s00406-019-01005-0

データ提供：米国国立医学図書館（NLM）

Venlafaxine: Unveiling the Complexities of Adverse Drug Reactions

The [use of venlafaxine] is a common therapeutic strategy, but understanding its [pharmacokinetic correlates and associated adverse reactions] is essential for patient safety and optimal treatment outcomes. This research investigates the potential link between venlafaxine plasma concentrations, its active metabolite, and adverse drug reactions (ADRs) in a large naturalistic sample of patients.

A Complex Landscape: Exploring the Relationship Between Venlafaxine and ADRs

The study's findings do not demonstrate a direct link between venlafaxine metabolism measures and ADRs. This suggests that other factors, potentially beyond pharmacokinetics, may contribute to the development of ADRs in patients receiving venlafaxine. Further research is needed to unveil the intricate interplay between venlafaxine, its metabolism, and the occurrence of ADRs.

Navigating the Desert of ADRs: Understanding Venlafaxine's Complexities

The study's findings highlight the need for a more comprehensive understanding of the factors contributing to ADRs in patients receiving venlafaxine. While pharmacokinetics might play a role, other factors like individual patient characteristics and genetic variations might also influence the likelihood of ADRs. This understanding is essential for optimizing venlafaxine treatment and minimizing potential adverse effects.

Dr.Camel's Conclusion

The desert of pharmacokinetic research can be vast and complex. This study underscores the need for a deeper understanding of the factors contributing to ADRs in patients receiving venlafaxine. The intricate interplay between pharmacokinetics, individual patient characteristics, and genetic variations might be the key to unlocking the secrets of ADRs, ultimately leading to improved patient safety and treatment outcomes.

Date :
  1. Date Completed 2020-02-10
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

30923938

DOI: Digital Object Identifier

10.1007/s00406-019-01005-0

SNS
PICO Info
in preparation
Languages

English

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