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Immunogenicity and Safety of a Sabin Strain-Based Inactivated Polio Vaccine: A Phase 3 Clinical Trial.

Author: ChenLei, ChuKai, HuYuemei, JiangDeyu, LiChanggui, WangJianfeng, YinWeidong, YingZhifang, ZengGang, ZhuFengcai, ZhuFengdong

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The Sabin strain-based inactivated polio vaccine (sIPV) demonstrated an immunogenicity profile noninferior to that of the conventional IPV and had a good safety profile. Seroconversion rates were higher in the sIPV group for all three poliovirus types.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The Sabin strain-based inactivated polio vaccine (sIPV) plays a vital role in eradicating poliomyelitis in developing countries. METHODS: The study was designed as a randomized, controlled, double-blinded, noninferiority trial. A total of 1200 healthy infants aged 60-90 days were enroll...See full text at original site
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引用元：
https://doi.org/10.1093/infdis/jiy736

データ提供：米国国立医学図書館（NLM）

A New Vaccine for Polio: A Step Towards Eradication

Polio, a debilitating disease that once ravaged the world, is a constant threat, especially in developing countries. The search for effective vaccines has been a long and arduous journey, like traversing a vast desert seeking a source of clean water. This study focuses on the safety and efficacy of a Sabin strain-based inactivated polio vaccine (sIPV). The study, conducted in a double-blinded manner, compared the sIPV to the conventional IPV. The results, much like finding a hidden oasis in the desert, demonstrated that the sIPV was non-inferior to the conventional IPV in terms of immunogenicity and had a favorable safety profile. This new vaccine could be a vital tool in the fight against polio, providing a safe and effective means of protecting children and ultimately contributing to the eradication of this devastating disease.

A Promising Step Towards Polio Eradication

The findings of this study demonstrate the potential of the sIPV to play a crucial role in polio eradication efforts. The non-inferiority of the sIPV to the conventional IPV, coupled with its good safety profile, suggests that it could be a valuable tool in the fight against this debilitating disease. This is a significant milestone in the desert of polio research, bringing us closer to a world free from this devastating illness.

A Beacon of Hope in the Fight Against Polio

The development of this new polio vaccine offers a beacon of hope in the fight against this crippling disease. It represents a crucial step towards achieving polio eradication and ensuring that future generations are protected from its devastating consequences. It's a reminder that even in the face of seemingly insurmountable challenges, human ingenuity and perseverance can lead to significant advancements in public health.

Dr.Camel's Conclusion

This research is a testament to the dedication and innovation of scientists in their relentless pursuit of a polio-free world. The development of the sIPV provides a valuable tool in this fight, and it's a reminder that even in the vast desert of global health challenges, there is always hope for a brighter future.

Date :
  1. Date Completed 2020-05-20
  2. Date Revised 2020-05-20
Further Info :

Pubmed ID

30958543

DOI: Digital Object Identifier

10.1093/infdis/jiy736

Related Literature

Article Analysis
・Side Effects of polio vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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