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Clinical Predictors of Response to Baclofen in the Treatment of Alcohol use Disorder: Results from the BacALD Trial.

Author: BaillieAndrew, HaberPaul S, MorleyKirsten C, RomboutsSusan A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Baclofen, relative to placebo, was more effective in patients with alcohol use disorder (AUD) who had higher alcohol consumption at baseline. There were no predictive effects of other baseline characteristics on time to lapse or time to relapse.
Paper Details　
Original Abstract of the Article :
AIM: To examine clinical predictors of treatment response to baclofen in patients with alcohol use disorder (AUD). METHODS: Data from a randomised controlled trial (RCT) (N = 104), in which AUD patients received placebo or baclofen (30 mg/day or 75 mg/day) for 12 weeks, were analysed to determine p...See full text at original site
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引用元：
https://doi.org/10.1093/alcalc/agz026

データ提供：米国国立医学図書館（NLM）

Predicting Baclofen Response in Alcohol Use Disorder

Alcohol use disorder (AUD) is a complex and prevalent condition that can significantly impact individuals' lives. This study explores the potential of baclofen, a medication typically used to treat muscle spasms, as a treatment for AUD. The researchers conducted a randomized controlled trial (RCT) to investigate the efficacy of baclofen in reducing alcohol consumption and relapse rates in patients with AUD. They also examined clinical predictors of treatment response to baclofen.

Finding the Right Path to Recovery

The study's findings suggest that baclofen may be more effective in reducing alcohol consumption and relapse rates in patients with higher baseline alcohol consumption. The researchers observed that baclofen was more effective in increasing time to first lapse and time to first relapse in patients who consumed more alcohol before starting treatment. This suggests that baclofen may be particularly beneficial for individuals with more severe AUD.

A Personalized Approach to AUD Treatment

This research underscores the importance of individualizing treatment approaches for AUD, a condition that can vary greatly in severity and presentation. The study's findings suggest that baclofen may be a viable option for some individuals with AUD, particularly those with higher baseline alcohol consumption. This study serves as a reminder that the desert of AUD treatment is vast and complex, requiring a personalized approach to maximize treatment effectiveness.

Dr.Camel's Conclusion

This study is a compass guiding us through the desert of AUD treatment. It highlights the importance of considering individual characteristics, such as baseline alcohol consumption, when selecting a treatment approach. It also underscores the potential of baclofen as a treatment for AUD, particularly for individuals with more severe forms of the condition.

Date :
  1. Date Completed 2019-11-25
  2. Date Revised 2019-11-25
Further Info :

Pubmed ID

30977770

DOI: Digital Object Identifier

10.1093/alcalc/agz026

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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