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Dissociable effects of cannabis with and without cannabidiol on the human brain's resting-state functional connectivity.

Author: BloomfieldMichael Ap, CurranH Valerie, DemetriouLysia, FeildingAmanda, FreemanAbigail M, FreemanTom P, HindochaChandni, KowalczykOliwia S, LawnWill, MokryszClaire, NuttDavid, PopeRebecca, WallMatthew B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

THC disrupts the default mode network (DMN), and the posterior cingulate cortex (PCC) is a key brain region involved in the subjective experience of THC intoxication. CBD restores disruption of the salience network by THC.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Two major constituents of cannabis are Δ AIMS: We examined the effects of two strains of cannabis and placebo on the human brain's resting-state networks using fMRI. METHODS: Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug treatments...See full text at original site
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引用元：
https://doi.org/10.1177/0269881119841568

データ提供：米国国立医学図書館（NLM）

Cannabis and the Brain: Unveiling the Impact of THC and CBD

The impact of [cannabis] on the [human brain] is a complex and multifaceted area of [neuroscience]. This study explores the effects of [cannabis with and without cannabidiol (CBD)] on [resting-state functional connectivity] in the brain using [fMRI]. It's like taking a journey through the intricate network of the human brain, seeking to understand the influence of this widely used substance.

THC's Impact on Brain Networks: A Complex Landscape

This study found that [THC] disrupts the [default mode network (DMN)] and [salience network (SAL)], which play crucial roles in [cognition and emotional processing]. Interestingly, [CBD] appears to mitigate the disruptive effects of [THC] on the [salience network]. It's like navigating a complex desert landscape, where some paths are disrupted but others remain open.

Navigating the World of Cannabis: A Need for Understanding

This study sheds light on the potential therapeutic implications of [CBD] in mitigating the negative effects of [THC] on the brain. It underscores the importance of understanding the [neurobiological mechanisms] involved in the effects of [cannabis] and the potential for [CBD] to play a beneficial role in managing certain health conditions. It's a reminder that even in the vast and sometimes enigmatic desert of [neuroscience], there are opportunities to find new oases of understanding and healing.

Dr. Camel's Conclusion

This study offers valuable insights into the complex interplay between [cannabis, THC, and CBD] on the [human brain]. It highlights the potential for [CBD] to play a role in mitigating the negative effects of [THC]. It's a reminder that the desert of [neuroscience] is vast and full of hidden oases, where continued research and exploration can lead to new discoveries and breakthroughs.

Date :
  1. Date Completed 2020-07-28
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

31013455

DOI: Digital Object Identifier

10.1177/0269881119841568

Related Literature

Article Analysis
・Effects of cannabidiol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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