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Selective gastric antilesion properties of rioprostil, a prostaglandin E1 analog, in rats and dogs.
Author: KatzL B, RosenthaleM E, ShriverD A, TobiaA J
Original Abstract of the Article :
This paper characterizes the ability of rioprostil, a synthetic primary alcohol prostaglandin E1 analog, to inhibit gastric acid secretion and prevent experimentally induced gastric lesions in rats and dogs, and determines the selectivity (the separation in potency) for these effects. In 4-hr pyloru...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/3116199
データ提供:米国国立医学図書館(NLM)
Rioprostil: A Prostaglandin E1 Analog with Targeted Action
This study explores the [pharmacology] of rioprostil, a synthetic prostaglandin E1 analog, and its effects on gastric acid secretion and prevention of gastric lesions. Rioprostil, like a camel that can carefully navigate treacherous terrain, aims to protect the delicate lining of the stomach. The study investigated rioprostil's ability to inhibit gastric acid secretion and prevent lesions induced in rats and dogs.
The researchers found that rioprostil effectively inhibited gastric acid secretion and prevented lesions in both rats and dogs. The study also showed that rioprostil had a high degree of selectivity, meaning it was more potent in preventing lesions than in inhibiting acid secretion. This selective action is like a camel that can delicately pick its way through a thorny bush without causing damage.
Protecting the Stomach Lining
The study demonstrated that rioprostil is a promising therapeutic agent for protecting the stomach lining from damage. This is particularly significant for individuals who are at risk for gastric ulcers, such as those taking certain medications or suffering from conditions like gastritis.
A New Tool for Gastrointestinal Health
This research provides valuable insights into the potential of prostaglandin E1 analogs like rioprostil for treating gastrointestinal disorders. It's a reminder that scientific innovation can lead to new tools for protecting our health and well-being.
Dr. Camel's Conclusion
This study shows the potential of rioprostil as a valuable tool for protecting the stomach lining. It's a reminder that, just like a camel can navigate a harsh desert environment, rioprostil can provide protection in a challenging gastrointestinal landscape.
Date :
- Date Completed 1987-11-05
- Date Revised 2018-11-30
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English
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