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An update on pathogenesis of psoriatic arthritis and potential therapeutic targets.

Author: CasoFrancesco, ChimentiMaria Sole, ConigliaroPaola, CostaLuisa, De MartinoErica, FontiGiulia Lavinia, PerriconeCarlo, PerriconeRoberto, SunziniFlavia, TriggianesePaola

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review summarizes research on psoriatic arthritis (PsA), a condition that affects the joints and skin. The review highlights that PsA is influenced by multiple factors, including the immune system, bone remodeling, and genetics. It also discusses promising new treatments, including medications that target specific immune pathways, such as IL-17 inhibitors, abatacept, JAK inhibitors, and others. The review concludes that there are multiple potential treatment options for PsA, but further research is needed to understand how best to tailor treatments to individual patients.
Paper Details　
Original Abstract of the Article :
<b>Introduction</b>: Innate immune response and bone remodeling are key factors contributing to the pathogenesis of psoriatic arthritis (PsA). Moreover, the evidence of autoantibodies in patients' sera suggests an autoimmune side in PsA. Besides the immune pathways, studies strongly support the rol...See full text at original site
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引用元：
https://doi.org/10.1080/1744666X.2019.1627876

データ提供：米国国立医学図書館（NLM）

Psoriatic Arthritis: A Complex Desert Landscape

Psoriatic arthritis (PsA), an inflammatory disease that affects the joints and skin, presents a complex and multifaceted challenge for healthcare providers. This review delves into the intricate pathogenesis of PsA, exploring the interplay of innate immunity, autoimmunity, and bone remodeling. The authors meticulously examine the evidence for various therapeutic targets, providing insights into the evolving landscape of PsA treatment.

Unraveling the Mysteries: Exploring the Desert's Hidden Paths

The review offers a comprehensive overview of the intricate mechanisms underlying PsA, highlighting the critical roles of innate immunity, autoimmunity, and bone remodeling. Imagine a vast desert, where multiple paths converge and diverge, creating a complex and interconnected network. PsA, like this desert landscape, is characterized by intricate pathways that contribute to its development and progression.

A New Era of Treatment: Seeking an Oasis of Relief

The review examines the promise of several emerging therapies for PsA, including IL-17 inhibitors, abatacept, JAK inhibitors, and other novel agents. These developments offer hope for individuals with PsA, potentially providing more effective and targeted treatment options. The search for effective treatments for PsA is like seeking an oasis in the desert, a haven of relief and improved quality of life.

Dr. Camel's Conclusion

This review provides a comprehensive and insightful exploration of the pathogenesis and treatment of PsA. It highlights the complexity of this disease and the need for a multidisciplinary approach to effectively manage its diverse manifestations. As a researcher, I am constantly seeking new ways to understand and address the challenges of inflammatory diseases, and this review offers a valuable roadmap for future research and therapeutic development. The search for effective treatments for PsA is a journey through a complex and challenging desert, but with continued research and innovation, we can find pathways to better manage this debilitating condition.

Date :
  1. Date Completed 2020-06-15
  2. Date Revised 2020-06-15
Further Info :

Pubmed ID

31177868

DOI: Digital Object Identifier

10.1080/1744666X.2019.1627876

Related Literature

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・Effective treatment of psoriatic arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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