The effect of anti-emetic drugs on rat embryonic heart activity.

Author: HussIsabelle Broström, RitchieHelen E, WebsterWilliam S

Paper Details 
Original Abstract of the Article :
Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect o...See full text at original site
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引用元:
https://doi.org/10.1016/j.reprotox.2019.06.002

データ提供:米国国立医学図書館(NLM)

Navigating the Sands of Pregnancy: Anti-Emetic Drugs and Embryonic Heart Activity

As a seasoned camel traversing the vast desert, I've seen countless travelers, both human and animal, affected by the harsh conditions. In the world of medicine, we're always looking for ways to alleviate suffering, particularly during sensitive periods like pregnancy. This study, like a map guiding us through treacherous terrain, explores the effects of anti-emetic drugs, used to combat nausea and vomiting, on the developing heart of rat embryos. The study, like a camel caravan carefully navigating a sandstorm, highlights the potential risks associated with certain anti-emetics, particularly those that block the hERG potassium channel, which is crucial for maintaining a healthy heart rhythm.

A Cautionary Tale for Pregnant Travelers

The research demonstrates that all tested anti-emetics, including droperidol, domperidone, granisetron, metoclopramide, and trifluoperazine, led to a concentration-dependent slowing of the heart rate in rat embryos. This discovery, like finding a hidden oasis, raises concerns about the potential for these medications to affect heart development in human fetuses. However, the researchers emphasize the need for further research to clarify the specific risks and benefits of these medications for pregnant women.

The Importance of Responsible Travel in the Desert of Pregnancy

Navigating the desert of pregnancy can be a delicate journey. Just as a camel carefully chooses its path to avoid treacherous dunes, pregnant women need to be aware of the potential risks associated with medications. This study highlights the importance of consulting with healthcare professionals to make informed decisions about medication use during pregnancy. They can help you weigh the potential benefits against the risks and ensure the safest possible journey for both you and your developing child.

Dr. Camel's Conclusion

This study, like a well-worn trail across the desert, reminds us of the importance of careful consideration when using medications during pregnancy. The potential impact on the developing fetus needs to be carefully evaluated, and open communication between patients and healthcare providers is crucial to ensure a safe and healthy journey through the desert of pregnancy.
Date :
  1. Date Completed 2020-03-13
  2. Date Revised 2020-03-13
Further Info :

Pubmed ID

31199962

DOI: Digital Object Identifier

10.1016/j.reprotox.2019.06.002

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