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Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review.

Author: AlvesGilberto, BickerJoana, FalcãoAmílcar, FortunaAna, GonçalvesJoana, GouveiaFilipa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

New techniques are being developed to measure the levels of direct oral anticoagulants (DOACs) in the blood.
Paper Details　
Original Abstract of the Article :
Direct oral anticoagulants (DOACs) are first-line drugs used for the treatment of venous thromboembolism and prevention of stroke in patients with atrial fibrillation. These drugs do not require the regular biochemical monitoring that is mandatory for warfarin, and they exhibit shorter half-lives an...See full text at original site
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引用元：
https://doi.org/10.1016/j.aca.2019.03.061

データ提供：米国国立医学図書館（NLM）

Monitoring Direct Oral Anticoagulants: Navigating the Sands of Personalized Therapy

Direct oral anticoagulants (DOACs) have revolutionized the treatment of blood clots and stroke prevention. They are like a desert oasis offering relief from the dangers of blood clotting. However, monitoring the effectiveness of these drugs is crucial for ensuring optimal patient outcomes. This research explores the use of liquid chromatography-mass spectrometry (LC-MS) to accurately determine DOAC levels in blood samples. It's like using a sophisticated compass to navigate the sands of personalized therapy and fine-tune treatment.

LC-MS: A Precise Tool for Navigating the Desert

LC-MS has emerged as the gold standard method for precisely measuring DOAC levels in blood samples. It's like a highly accurate compass, guiding physicians towards the right dosage and ensuring the optimal therapeutic response. This is particularly important since recent studies have shown that DOACs may have a higher prevalence of side effects than initially anticipated. By precisely measuring drug levels, healthcare providers can tailor treatment to individual patient needs and minimize the risk of complications.

Personalized Therapy: A Desert Oasis of Precision

This research underscores the importance of personalized therapy, ensuring that patients receive the right dose of medication at the right time. It's like discovering a unique oasis in the desert, tailored to the specific needs of each traveler. By using precise monitoring techniques, healthcare providers can help patients navigate the landscape of blood clotting disorders and achieve optimal outcomes.

Dr.Camel's Conclusion

LC-MS is a powerful tool for navigating the desert of personalized therapy, ensuring that patients receive the right amount of medication to manage their condition. It's like having a map and compass in hand, guiding us towards a healthier and safer journey through the landscape of blood clotting disorders.

Date :
  1. Date Completed 2019-10-07
  2. Date Revised 2019-10-07
Further Info :

Pubmed ID

31203961

DOI: Digital Object Identifier

10.1016/j.aca.2019.03.061

SNS
PICO Info
in preparation
Languages

English

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