Intrinsic Replication Competences of HIV Strains After Zidovudine/Lamivudine/Nevirapine Treatment in the Philippines.

Author: Amolong HinayAlfredo, KageyamaSeiji, KanaiKyosuke, LeanoPrisca Susan Agustin, SamonteGenesis May Jopson, TelanElizabeth Freda Omengan, Tsuneki-TokunagaAkeno

Paper Details 
Original Abstract of the Article :
Although drug-resistant HIV variants are considered to be less fit than drug-susceptible viruses, replication competence of these variants harbored by patients has not yet been elucidated in detail. We herein assessed the replication competence of strains obtained from individuals receiving antiretr...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748504/

データ提供:米国国立医学図書館(NLM)

HIV Resistance: A Desert of Drug-Resistant Strains

HIV, like a relentless desert wind, can erode the body's defenses over time. While antiretroviral therapy can create a temporary oasis of hope, drug-resistant strains of HIV can emerge, posing a formidable challenge to treatment.

This research delves into the replication competence of drug-resistant HIV strains found in individuals undergoing antiretroviral therapy. The study, like a careful analysis of the desert landscape, investigated the ability of these strains to replicate in the absence of drugs, a crucial factor in determining their potential to persist and spread.

Drug-Resistant Strains: A Persistent Mirage

The researchers found that drug-resistant strains, while less fit than drug-susceptible viruses, retained a significant ability to replicate, like a desert oasis that appears to be flourishing but holds a hidden danger. This discovery emphasizes the importance of continuous monitoring and adaptation of treatment strategies to combat the emergence of these resistant strains.

Health Implications and Life Applications

The findings of this study highlight the ongoing struggle against HIV, even with effective antiretroviral therapies. The emergence of drug-resistant strains emphasizes the need for vigilant monitoring and proactive management of HIV infection, ensuring that treatment strategies are continually refined to outmaneuver the ever-evolving desert of HIV resistance.

Dr.Camel's Conclusion

The fight against HIV is a continuous battle against a formidable desert foe. This study highlights the resilience of drug-resistant strains, reminding us that the desert landscape of HIV infection is ever-changing. By understanding the adaptability of these strains, we can develop more robust strategies to create sustainable oases of health for those living with HIV.
Date :
  1. Date Completed 2020-07-15
  2. Date Revised 2020-07-15
Further Info :

Pubmed ID

31216920

DOI: Digital Object Identifier

PMC6748504

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