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Oral isotretinoin for treating mucocutaneous human papillomavirus infections: A systematic review and meta-analysis.

Author: HuangYu-Chen, LeeTsai-Hsien, YangTing-Hua

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Oral isotretinoin is superior to placebo for treating mucocutaneous human papillomavirus infections, particularly plane warts, with a low recurrence rate and risk of severe side effects.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Some viral warts are refractory to treatment, some others tend to recur. Oral isotretinoin is useful against warts to varying degrees. OBJECTIVE: To determine the efficacy of oral isotretinoin for treating mucocutaneous human papillomavirus infections. METHODS: A systematic review an...See full text at original site
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引用元：
https://doi.org/10.4103/ijdvl.IJDVL_269_18

データ提供：米国国立医学図書館（NLM）

Oral Isotretinoin: A Promising Treatment for Mucocutaneous Human Papillomavirus Infections

Human papillomavirus (HPV) infections can lead to various skin and mucosal lesions, including warts. This systematic review and meta-analysis examine the efficacy of oral isotretinoin, a retinoid drug, in treating mucocutaneous HPV infections. The authors analyzed eight studies, including randomized controlled trials and case series, focusing on the response rates and recurrence of HPV lesions.

Oral Isotretinoin Demonstrates Effectiveness Against HPV Infections

The meta-analysis revealed that oral isotretinoin was significantly more effective than placebo in treating mucocutaneous HPV infections. The pooled estimate of the complete response rate was 67.7%, indicating a substantial improvement in lesion clearance. While recurrence did occur in some patients, the overall recurrence rate was relatively low.

Considering Oral Isotretinoin for HPV Treatment

This study suggests that oral isotretinoin could be a valuable therapeutic option for patients with mucocutaneous HPV infections, particularly plane warts. However, like a wise camel navigating a desert of potential side effects, healthcare providers should carefully consider individual patient factors and weigh the benefits and risks before prescribing isotretinoin.

Dr.Camel's Conclusion

The desert of HPV infections can be a challenging one to traverse, but this research offers a glimmer of hope with the potential of oral isotretinoin. It reminds us that continued exploration and innovation are key to finding new solutions for treating this persistent and sometimes troublesome condition.

Date :
  1. Date Completed 2020-02-28
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

31274470

DOI: Digital Object Identifier

10.4103/ijdvl.IJDVL_269_18

Related Literature

Article Analysis
・Effective treatment of warts
SNS
PICO Info
in preparation
Languages

English

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