Effective treatment of warts: A Synthesis of Findings from 67 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have shown that some treatments are more effective than conventional methods. For example, 46 reports that a combination of cryotherapy and immunotherapy is more effective in treating multiple common warts than conventional cryotherapy alone. Also, 47 found that nanovesicular photodynamic therapy is an effective treatment for resistant plantar warts. Additionally, 50 reports that intralesional immunotherapy, which involves injecting medication directly into the wart, is more effective than first-line treatments such as salicylic acid or cryotherapy.

On the other hand, 29 states that there is not enough research on wart treatments. Also, 22 suggests that the effectiveness of treatments may vary depending on the type of wart. For example, plantar warts may have different natural healing rates and treatment outcomes depending on the specific HPV type.

Treatment Summary

46 reports that a combination of cryotherapy and immunotherapy is more effective than conventional cryotherapy alone. Also, 47 found that nanovesicular photodynamic therapy is an effective treatment for resistant plantar warts. Additionally, 50 reports that intralesional immunotherapy, which involves injecting medication directly into the wart, is more effective than first-line treatments such as salicylic acid or cryotherapy.

Benefits and Risks

Benefit Summary

Research has shown that several treatments have the potential to be more effective than conventional methods. These include a combination of cryotherapy and immunotherapy, nanovesicular photodynamic therapy, and intralesional immunotherapy.

Risk Summary

Some treatments carry the risk of side effects. For example, photodynamic therapy can cause skin inflammation and pigmentation. Intralesional immunotherapy may cause pain and swelling at the injection site. The effectiveness of treatment may also vary depending on the type of wart.

Comparison Between Studies

Similarities

Many studies show that there are various treatments for warts and some treatments are more effective than conventional methods.

Differences

Each study looks at different types of warts, different treatments, and different evaluation methods, making it difficult to directly compare the results.

Consistency and Contradictions in the Results

There are both consistent and contradictory findings among the research. For example, several studies have shown that a combination of cryotherapy and immunotherapy is effective, but 22 suggests that the effectiveness of treatments may vary depending on the type of wart.

Notes on Applying the Results to Real Life

There are some things to consider when applying research findings to everyday life. First, the effectiveness of treatments may vary depending on the type of wart and individual’s health. Therefore, it is important to consult a doctor before starting treatment. Also, there is a chance of the wart recurring after treatment. Therefore, it is important to follow up with your doctor regularly after treatment.

Limitations of Current Research

Current research has limitations, such as variations in the types of warts studied, treatment methods used, and evaluation methods employed, making it difficult to directly compare results. Also, many studies are relatively small, making it difficult to generalize the findings.

Future Research Directions

To make wart treatment more effective, the following research is needed in the future: * Research to identify the best treatment for different types of warts. * Research to verify the effectiveness of treatments in larger studies. * Research to develop methods to prevent recurrence after treatment.

Conclusion

There are various treatments for warts, and several treatments have been shown to be more effective than conventional methods. However, the best treatment may vary depending on the type of wart and individual’s health, so it is important to consult with a doctor before starting treatment. Also, warts can recur after treatment, so regular follow-ups with your doctor are important.

List of Treatments

• Cryotherapy • Immunotherapy • Photodynamic therapy • Intralesional immunotherapy • Salicylic acid therapy

Keywords
Benefit Keywords
Treatment for warts
1
Wart treatment
2
Improved wart clearance
4
Improved understanding of genital warts
5
Improved genital warts treatment
6
Reduced recurrence
7
Effective treatment of genital warts
8
Wart clearance
9
Wart treatment
10
Wart clearance
11
Effective wart treatment
12
Wart resolution
13
Effective treatment for warts
14
Painless treatment
Wart treatment efficacy
15
Improved genital wart treatment
16
Effective treatment
Wart treatment
17
Wart treatment
18
Improved cure rates
19
Flat wart treatment
20
Clear warts
21
Wart cure
22
Wart clearance
23
Genital wart treatment
24
Treat anogenital warts
25
Complete resolution of warts
Reduced viral load
26
AGW treatment
27
Complete resolution
Reduced number of warts
28
AGW treatment
29
Wart treatment
30
Improved QoL
Wart clearance
31
Wart treatment
32
Wart treatment
33
CWARTS tool for warts
HPV genotype predicts treatment
34
Cryotherapy for AGWs
35
Complete remission of plane warts
36
Effective treatment
Wart reduction
37
Wart treatment
38
Anogenital warts treatment
Cryotherapy
Topical agents
qHPV vaccination
39
Effective wart treatment
40
Effective wart treatment
41
HPV treatment
42
Wart clearance
43
Good cosmetic outcome
Wart clearance
44
Diphencyprone for warts
45
Wart treatment
46
Plantar wart treatment
47
Improved anogenital wart treatment
48
Few sessions
Low recurrence
More effective
49
Complete resolution of distant warts
Efficacy for warts
50
anogenital warts
intralesional immunotherapy
51
Improved plantar wart treatment
52
Genital warts treatment
53
Cryotherapy for anogenital warts
54
Wart clearance
55
Urethral wart clearance
56
Candida antigen for warts
57
Wart clearance
58
Effective treatment
Safe treatment
59
Minimal side effects
Wart treatment
60
Distant warts
High efficacy
61
Plantar wart treatment
Recurrence reduction
62
Plantar wart treatment
63
Reduced treatment sessions
Wart clearance
64
Genital wart treatment
65
Plantar wart treatment
66
Effective treatment
Increased clearance rate
67
Risk Keywords
Different response rates between men and women
8
Mucosal erosion
9
Insufficient evidence
Treatment toxicity
10
Blistering
Irritation
Pain
11
Toxic treatments
12
Variable efficacy of placebo
14
Genital warts
16
None reported
17
Blistering
Pain
Scarring
21
Cheilitis
23
Refractory warts
25
Anogenital warts
26
Hypopigmentation
Infection of donor site
Keloid formation
28
Limited data
Local AE
Pain
31
Wart treatment efficacy
32
Adverse effects
35
Cheilitis
Erythema
Scaling
36
Side effects
38
Adverse events
40
Hypopigmentation
41
Recurrence
42
Adverse effects
43
Fatigue
Injection pain
Numbness
44
Emotional distress
Variable retinoid results
54
Transient adverse effects
55
Adverse events
56
Side effects
58
Inflammation
Necrosis
Pain
Scar
59
Mild side effects
60
None reported
64
Literature analysis of 67 papers
Positive Content
65
Neutral Content
1
Negative Content
1
Article Type
48
9
18
13
67
1.

An assessment of methods of treating viral warts by comparative treatment trials based on a standard design.

Author: BunneyM H, NolanM W, WilliamsD A

Treatment for warts

A series of 11 comparative wart treatment trials involving 1802 patients found that liquid nitrogen was effective in treating hand warts, with a higher cure rate when freezings were done at 3-week intervals. A paint containing salicylic and lactic acids was effective in treating simple plantar warts.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Modern treatment of warts: cure rates at 3 and 6 months.

Author: Berth-JonesJ, HutchinsonP E

Wart treatment

A study of 400 patients with warts found that a combination of cryotherapy, keratolytic paint, and paring resulted in a 52% cure rate after 3 months. The chance of cure was lower for patients with a longer history of warts and larger warts. Paring improved the cure rate for plantar warts but not hand warts. After an additional 3 months of treatment, the cure rate dropped to 41%, and neither continued cryotherapy nor inosine pranobex significantly improved the outcome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Homeopathic treatment of plantar warts.

Author: LabrecqueM, AudetD, LatulippeL G, DrouinJ

Homeopathic treatment was no more effective than placebo in the treatment of plantar warts.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Liquid nitrogen and salicylic/lactic acid paint in the treatment of cutaneous warts in general practice.

Author: SteeleK, IrwinW G

Improved wart clearance

A study of patients with common hand warts and simple plantar warts found that combining liquid nitrogen and wart paint was more effective in treating common hand warts than either treatment alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Topical 0.3% and 0.5% podophyllotoxin cream for self-treatment of condylomata acuminata in women. A placebo-controlled, double-blind study.

Author: SyedT A, LundinS, AhmadS A

Improved understanding of genital warts

Genital warts are a common sexually transmitted infection that are different from skin warts. They are more common worldwide than previously thought. Women are more likely to be unaware of genital warts because they can be difficult to see.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The cost of treating genital warts.

Author: StraussM J, KhannaV, KoenigJ D, DownsS M, GoldbergS H, ManyakM J, PatsnerB

Improved genital warts treatment

This study compared the effectiveness, cost, and cost-effectiveness of five common treatments for genital warts. While current treatments provide temporary relief, they do not guarantee a long-term cure. The study reviewed medical literature, claims data, and consulted with experienced practitioners to assess the different treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Treatment of genital HPV infection with carbon dioxide laser and systemic interferon alpha-2b.

Author: NieminenP, AhoM, LehtinenM, VesterinenE, VaheriA, PaavonenJ

Reduced recurrence

Adjuvant systemic interferon alpha-2b treatment following carbon dioxide laser ablation of genital HPV lesions was beneficial only for patients infected with HPV DNA 16/18.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Treatment of external genital warts in men using 5% imiquimod cream applied three times a week, once daily, twice daily, or three times a day.

Author: FifeK H, FerenczyA, DouglasJ M, BrownD R, SmithM, OwensM L,

Effective treatment of genital warts
Different response rates between men and women

Current treatments for genital warts are not always successful. Imiquimod cream, which stimulates the immune system, has been shown to be effective for treating genital warts in the genital and anal areas, but women are more likely to experience complete clearance of warts compared to men. About two-thirds of women clear their warts with imiquimod cream applied three times a week for up to 16 weeks, compared to only about one-third of men.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Efficacy and tolerability of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected persons.

Author: MatteelliA, BeltrameA, GraifemberghiS, ForleoM A, GullettaM, CiravoloG, TedoldiS, CasaliniC, CarosiG

Wart clearance
Mucosal erosion

Topical 1% cidofovir cream was found to be significantly more effective than vehicle cream for the initial clearance of anogenital warts in HIV-infected patients. However, local mucosal erosion was a common side effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Local treatments for cutaneous warts.

Author: GibbsS, HarveyI, SterlingJ C, StarkR

Wart treatment
Insufficient evidence
Treatment toxicity

Simple topical treatments containing salicylic acid are clearly more effective than placebo for the treatment of cutaneous, non-genital warts. There is less evidence for the efficacy of cryotherapy and no convincing evidence that it is any more effective than simple topical treatments. Dinitrochlorobenzene appears to be effective but no more so than the safer, simpler and cheaper topical treatments containing salicylic acid.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Local treatments for cutaneous warts: systematic review.

Author: GibbsSam, HarveyIan, SterlingJane, StarkRosemary

Wart clearance
Blistering
Irritation
Pain

Topical treatments containing salicylic acid were found to be effective for cutaneous warts. Pooled data from 6 placebo controlled trials showed a cure rate of 75% in cases compared with 48% in controls.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Local treatments for cutaneous warts.

Author: GibbsS, HarveyI, SterlingJ C, StarkR

Effective wart treatment
Toxic treatments

This review found that simple topical treatments containing salicylic acid are clearly better than placebo for treating cutaneous non-genital warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Intralesional immunotherapy of warts with mumps, Candida, and Trichophyton skin test antigens: a single-blinded, randomized, and controlled trial.

Author: HornThomas D, JohnsonSandra M, HelmRicki M, RobersonPaula K

Wart resolution

Intralesional immunotherapy using Candida, mumps, or Trichophyton skin test antigens is an effective treatment for warts, with significantly higher response rates and distant response rates in subjects receiving antigen.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Topical treatments for cutaneous warts.

Author: GibbsS, HarveyI

Effective treatment for warts
Variable efficacy of placebo

Simple topical treatments containing salicylic acid are effective for treating common warts. There is less evidence for the efficacy of cryotherapy, but it may be as effective as simpler and safer treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts.

Author: KhattarJoe A, MusharrafiehUmayya M, TamimHala, HamadehGhassan N

Painless treatment
Wart treatment efficacy

Topical zinc oxide is an efficacious, painless, and safe therapeutic option for wart treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Intralesional bleomycin in the treatment of cutaneous warts: a randomized clinical trial comparing it with cryotherapy.

Author: DharS B, RashidM M, IslamAzmm, BhuiyanMsi

Effective treatment
Wart treatment
None reported

Intralesional bleomycin injection was significantly more effective than cryotherapy in treating cutaneous warts. Clearance rates were 94.9% and 97% for bleomycin, compared to 76.5% and 82% for cryotherapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine.

Author: NofalA, NofalE

Wart treatment

While many treatments for common warts are available, there is no single best approach. A newer approach involves injecting certain substances into the warts to stimulate the immune system (intralesional immunotherapy) and has been shown to be effective for various types of warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

5-FU for genital warts in non-immunocompromised individuals.

Author: BatistaClaudio S, AtallahAlvaro N, SaconatoHumberto, da SilvaEdina Mk

Improved cure rates

The study found that topical 5-Fluorouracil (5-FU) treatment for genital warts was more effective than placebo or no treatment, meta-cresol-sulfonic acid (MCSA), and Podophylin. However, 5-FU was less effective than 5-FU combined with INFalpha-2a (high dose) and 5-FU + CO2 Laser + Inf alpha-2a (high dose). Further studies are needed to determine the benefits and risks of topical 5-FU.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

The successful treatment of flat warts with auricular acupuncture.

Author: NingSuli, LiFajie, QianLijie, XuDong, HuangYi, XiaoMing, DuanGengli, LiYan

Flat wart treatment

Auricular acupuncture was explored as a treatment for flat warts in patients who were unsatisfied with conventional medical care due to potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Topical treatments for cutaneous warts.

Author: KwokChun Shing, GibbsSam, BennettCathy, HollandRichard, AbbottRachel

Clear warts
Blistering
Pain
Scarring

Salicylic acid significantly increased the chance of clearance of warts, especially for hand warts. Cryotherapy did not demonstrate a significant difference in effectiveness compared to placebo or salicylic acid.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

HPV type in plantar warts influences natural course and treatment response: secondary analysis of a randomised controlled trial.

Author: BrugginkSjoerd C, GusseklooJacobijn, de KoningMaurits N C, FeltkampMariet C W, BavinckJan Nico Bouwes, QuintWim G V, AssendelftWillem J J, EekhofJust A H

Wart cure

HPV type influenced the natural course and response to treatment for plantar warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

A double-blind, randomized, placebo-controlled trial of oral isotretinoin in the treatment of recalcitrant facial flat warts.

Author: Olguin-GarcíaMaría Guadalupe, Jurado-Santa CruzFermín, Peralta-PedreroMaría Luisa, Morales-SánchezMartha Alejandra

Wart clearance
Cheilitis

A double-blind, randomized controlled trial of isotretinoin for the treatment of recalcitrant facial flat warts showed complete clearance of all flat warts in 16 patients treated with isotretinoin, compared to no improvement in 15 patients treated with placebo. The most frequent adverse event was cheilitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men.

Author: CamargoCaio Lamunier de Abreu, Belda JuniorWalter, FagundesLuiz Jorge, RomitiRicardo

Genital wart treatment

Genital warts are caused by HPV and are a common sexually transmitted infection. While there's no treatment to eliminate HPV itself, most treatments focus on removing the warts. Potassium hydroxide, a strong alkali, has been shown to be safe and effective for genital warts. Cryotherapy is another common treatment. This study compares the effectiveness of potassium hydroxide and cryotherapy for genital warts.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

A randomized trial of efficacy of beta-sitosterol and its glucoside as adjuvant to cryotherapy in the treatment of anogenital warts.

Author: StefanakiChristina, FasoulakiXara, KourisAnargyros, CaroniChrysseis, PapagianakiKonstantina, MavrogianniPanagiota, NicolaidouElectra, GregoriouStamatis, AntoniouChristina

Treat anogenital warts
Refractory warts

The BSS-BSSG mixture gave promising results as an adjuvant to cryotherapy and may be used in patients with refractory warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Intralesional injection of Mycobacterium w vaccine vs imiquimod, 5%, cream in patients with anogenital warts: a randomized clinical trial.

Author: KumarPankaj, DarLalit, SaldiwalShashi, VarmaSangeeta, Datt UpadhyayAashish, TalwarDeepti, SharmaVinod Kumar, VermaKaushal Kumar, DwivediSada Nand, RajRama, GuptaSomesh

Complete resolution of warts
Reduced viral load
Anogenital warts

Imiquimod, 5%, and the Mw vaccine were equally effective in achieving clinical and virologic clearance for HPV-6. A significant decline in the HPV-11 viral load was achieved only with the Mw vaccine. Efficacy and safety of intralesional Mw vaccine is comparable to that of imiquimod, 5%, in treatment of AGWs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Imiquimod for anogenital warts in non-immunocompromised adults.

Author: Grillo-ArdilaCarlos F, Angel-MüllerEdith, Salazar-DíazLuis C, GaitánHernando G, Ruiz-ParraAriel I, LethabyAnne

AGW treatment

Genital warts (AGW) can disappear on their own in about 30% of people, but there's no way to predict which warts will go away. Many treatment options exist, chosen based on doctor and patient preferences. Imiquimod, a medication applied by the patient, may offer advantages over treatments given by a doctor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Safety and effectiveness of autoinoculation therapy in cutaneous warts: a double--blind, randomized, placebo--controlled study.

Author: LalNiharika Ranjan, SilAmrita, GayenTirthankar, BandyopadhyayDebabrata, DasNilay Kanti

Complete resolution
Reduced number of warts
Hypopigmentation
Infection of donor site
Keloid formation

Autoinoculation was an effective treatment for cutaneous warts, with 62.5% of patients achieving complete resolution after two sessions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Clinical effectiveness and cost-effectiveness of interventions for the treatment of anogenital warts: systematic review and economic evaluation.

Author: ThurgarElizabeth, BartonSamantha, KarnerCharlotta, EdwardsSteven J

AGW treatment

Genital warts are caused by HPV and can be physically uncomfortable and emotionally distressing. While many treatments are available, there's limited evidence on their effectiveness and cost-effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Laser Treatment of Nongenital Verrucae: A Systematic Review.

Author: NguyenJannett, KortaDorota Z, ChapmanLance W, KellyKristen M

Wart treatment

This review examined the use and efficacy of lasers in treating nongenital cutaneous warts. The lasers most studied were CO2, PDL, and Nd:YAG, with PDL showing the fewest adverse effects. Current evidence suggests that PDL may be equivalent to conventional therapies like cryotherapy and cantharidin, but further research is needed to establish optimal treatment protocols.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Self-administered interventions for anogenital warts in immunocompetent patients: a systematic review and meta-analysis.

Author: WernerRicardo Niklas, WestfechtelLukas, DresslerCorinna, NastAlexander

Improved QoL
Wart clearance
Limited data
Local AE
Pain

This systematic review and meta-analysis evaluated the available evidence from randomized controlled trials (RCTs) on topical treatments for anogenital warts (AGWs). Imiquimod 3.75% and 5% cream, podophyllotoxin 0.5% solution and gel, and polyphenon E 10% and 15% ointment were superior to placebo in terms of complete clearance (CC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

An expert system for selecting wart treatment method.

Author: KhozeimehFahime, AlizadehsaniRoohallah, RoshanzamirMohamad, KhosraviAbbas, LayeghPouran, NahavandiSaeid

Wart treatment
Wart treatment efficacy

This study developed a fuzzy logic rule-based system to predict the response of immunotherapy and cryotherapy for plantar and common warts, aiming to improve treatment selection and outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Intralesional immunotherapy compared to cryotherapy in the treatment of warts.

Author: KhozeimehFahime, Jabbari AzadFarahzad, Mahboubi OskoueiYaghoub, JafariMajid, TehranianShahrzad, AlizadehsaniRoohallah, LayeghPouran

Wart treatment

Warts, a common skin infection caused by the human papillomavirus (HPV), have no single proven treatment. This study compared the effectiveness of immunotherapy and cryotherapy (freezing) for treating warts.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Morphological characteristics and human papillomavirus genotype predict the treatment response in cutaneous warts.

Author: HogendoornG K, BrugginkS C, de KoningM N C, EekhofJ A H, HermansK E, RissmannR, BurggraafJ, WolterbeekR, QuintK D, KouwenhovenS T P, Bouwes BavinckJ N

CWARTS tool for warts
HPV genotype predicts treatment

Morphological characteristics of warts and the human papillomavirus (HPV) genotype influence treatment outcome and potentially influence future treatment decisions for common and plantar warts.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Cryotherapy to treat anogenital warts in nonimmunocompromised adults: Systematic review and meta-analysis.

Author: BertolottiAntoine, DupinNicolas, BouscaratFabrice, MilpiedBrigitte, DerancourtChristian

Cryotherapy for AGWs
Adverse effects

This study compared the efficacy and safety of cryotherapy versus other anogenital wart (AGW) treatments. Cryotherapy efficacy did not appear to differ from that of other treatments, but was associated with more immediate low-level adverse events.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Evaluation of the efficacy and safety of oral isotretinoin versus topical isotretinoin in the treatment of plane warts: a randomized open trial.

Author: KaurGagan J, BrarBalvinder K, KumarSumir, BrarSukhmani K, SinghBaltej

Complete remission of plane warts
Cheilitis
Erythema
Scaling

Oral isotretinoin is more effective than topical isotretinoin in treating plane warts. A randomized controlled trial of 29 patients found that oral isotretinoin led to complete remission in 69% of patients after 3 months of treatment, compared to 38% in the topical isotretinoin group. The most common side effect of oral isotretinoin was cheilitis, while topical isotretinoin caused severe erythema and scaling.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

The efficacy and safety of other cryotherapy compounds for the treatment of genital warts: a randomized controlled trial.

Author: FiroozA, HosseiniH, Izadi FirouzabadiL, Nassiri KashaniM, NasrollahiS A

Effective treatment
Wart reduction

The Wartner compound, a mixture of dimethyl ether and propane, was found to be as effective as liquid nitrogen in treating genital warts in male patients.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Evaluation of intralesional injection of bleomycin in the treatment of plantar warts: clinical and dermoscopic evaluation.

Author: BarkatManal T, Abdel-AzizRasha T A, MohamedMervat S

Wart treatment
Side effects

Intralesional injection of bleomycin is an effective and safe treatment of plantar warts with a cure rate of 69.3%. Dermoscope is recommended in the evaluation of treatment success.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

Human papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts (HIPvac trial).

Author: MurrayMacey L, MeadowsJade, DoréCaroline J, CopasAndrew J, HaddowLewis J, LaceyCharles, JitMark, SoldanKate, BennettKate, TetlowMichelle, NathanMayura, GilsonRichard

Anogenital warts treatment
Cryotherapy
Topical agents
qHPV vaccination

Anogenital warts are a common sexually transmitted infection. About 90% are caused by HPV types 6 and 11, and half of cases are recurrences. The best treatment for anogenital warts is unclear. Common treatments include topical medications like podophyllotoxin or imiquimod, and freezing (cryotherapy). While the HPV vaccine prevents infection, it's unclear if it can also treat existing warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

A double-blind, randomized controlled trial to compare the effectiveness and safety of purified protein derivative of tuberculin antigen with <i>Mycobacterium w</i> vaccine in the treatment of multiple viral warts.

Author: ChandraSomodyuti, SilAmrita, DattaAdrija, PalSantasmita, DasNilay Kanti

Effective wart treatment
Adverse events

Intradermal injection of Mycobacterium w (Mw) vaccine was more effective than purified protein derivative (PPD) of tuberculin antigen in treating warts. However, Mw vaccine was associated with a higher incidence of adverse effects, including ulceration, discharge, and pain-swelling-induration at the injection site.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Oral isotretinoin for treating mucocutaneous human papillomavirus infections: A systematic review and meta-analysis.

Author: YangTing-Hua, LeeTsai-Hsien, HuangYu-Chen

HPV treatment
Recurrence

Oral isotretinoin is superior to placebo for treating mucocutaneous human papillomavirus infections, particularly plane warts, with a low recurrence rate and risk of severe side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts.

Author: NofalAhmad, MareiAyman, IbrahimAl-Shimaa M, NofalEman, NabilManal

Wart clearance
Adverse effects

Intralesional injection of bivalent HPV vaccine was more effective than intramuscular injection in treating multiple recalcitrant common warts.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Successful Treatment of Multiple Common Warts With Intralesional Ozone.

Author: IbrahimAlshimaa M, ElkotReham A, KhashabaShrook A

Good cosmetic outcome
Wart clearance
Fatigue
Injection pain
Numbness

Intralesional ozone gas is an effective and safe treatment for multiple warts. In this study, 56.8% of patients treated with ozone achieved complete clearance, compared to 0% in the saline group. Mild side effects were reported, including pain, numbness, and fatigue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

The efficacy of diphencyprone immunotherapy for the treatment of cutaneous warts: a systematic review and meta-analysis.

Author: LeeyaphanCharussri, TantrapornpongPloypailin, UngprasertPatompong

Diphencyprone for warts

Diphencyprone immunotherapy has a high efficacy rate in curing warts and can be considered as an adjunctive modality for treatment failure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

'Cryo-immuno-therapy' is superior to intralesional <i>Candida antigen</i> monotherapy in the treatment of multiple common warts.

Author: AttwaEnayat, ElawadyRehab, SalahEman

Wart treatment

Treating common warts can be difficult. Freezing (cryotherapy) is often used, but results vary. Injecting a substance called Candida antigen into the wart has shown promise in treating different types of HPV infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Nanovesicular Photodynamic Clinical Treatment of Resistant Plantar Warts.

Author: FadelMaha, KassabKawser, SamyNevien, AbdelfadeelDoaa, YassinGhada, NasrMaha

Plantar wart treatment

This study investigated the efficiency of a nano-vesicular system (transfersomes) as a topical drug delivery system for the photosensitizer methylene blue (MB) in photodynamic therapy (PDT) for the treatment of plantar warts (PW). Transfersomal MB gel was found to be more effective than free MB gel, achieving a higher complete healing percentage at a lower number of treatment sessions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

A systematic review evaluating the efficacy and safety of a combination of ablative treatment and self administered treatment versus ablative treatment alone for external anogenital warts.

Author: FengCheng, LiWei, WangXiaojun, ZhangHailin, SiLoubin, ChenZhixiong, BaiMing

Improved anogenital wart treatment

This review compares the efficacy of ablative therapy alone versus the combination of ablative therapy with self-administered treatment for achieving complete clearance of external anogenital warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Intralesional cryotherapy versus cryotherapy spray for the treatment of recalcitrant plantar warts: a prospective, randomized study.

Author: AlbalatWaleed, AttwaEnayat, EbrahimHowyda Mohamed

Few sessions
Low recurrence
More effective

Intralesional cryotherapy (ILC) was found to be more effective than Cryotherapy spray (Cryo-sp) for treating recalcitrant plantar warts. In a study of 130 patients, complete clearance occurred in 80.3% of the ILC group compared to 50.8% in the Cryo-sp group. ILC also required fewer treatment sessions and had a lower recurrence rate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

50.

A review of intralesional wart therapy.

Author: MuseMikél E, StiffKatherine M, GlinesKatelyn R, ClineAbigail, FeldmanSteven R

Complete resolution of distant warts
Efficacy for warts

Intralesional wart injections are safe, affordable, and efficacious treatments for warts. They have equal or superior efficacy compared to first-line salicylic acid or cryotherapy. Physicians should consider intralesional injections for patients with refractory warts, multiple warts, or warts in sensitive areas.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Intralesional immunotherapy for the treatment of anogenital warts in pediatric population.

Author: NofalAhmad, AlakadRania

anogenital warts
intralesional immunotherapy

This study investigated the efficacy and safety of intralesional immunotherapy for treating multiple anogenital warts in children. The study found that both MMR vaccine and Candida antigen showed significantly better therapeutic response compared to saline. This suggests that intralesional immunotherapy is a promising and well-tolerated treatment option for anogenital warts in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

Efficacy and safety of intralesional injection of vitamin D<sub>3</sub> versus tuberculin PPD in the treatment of plantar warts: A comparative controlled study.

Author: Elsayed GhalyNahla, El-AshmawyAmal Ahmad, Abou ZeidMai, E ShakerEngi Seif

Improved plantar wart treatment

Intralesional tuberculin PPD and vitamin D3 injections were both effective in treating plantar warts. Vitamin D3 injections were more effective than PPD injections and showed a better response in male patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Topical and Systemic Retinoids for the Treatment of Genital Warts: A Systematic Review and Meta-Analysis.

Author: Oren-ShabtaiMeital, SnastIgor, LapidothMoshe, ShermanShany, NoymanYehonatan, MimouniDaniel, HodakEmmilia, LeviAssi

Genital warts treatment

Genital warts, caused by HPV, are a common sexually transmitted infection. They can go away on their own, but sometimes they persist. While many treatments exist, none can cure them completely, and they can come back. Retinoids, medications used for various skin problems, haven't been widely studied for treating genital warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Cryotherapy plus low-dose oral isotretinoin vs cryotherapy only for the treatment of anogenital warts: a randomized clinical trial.

Author: Reyna-RodríguezIrving Llibran, Chavez-AlvarezSonia, Garza-RodríguezVeronica, Franco-MarquezRodolfo, Gonzalez-MartinezGerardo, Ocampo-CandianiJorge, Villarreal-MartinezAlejandra

Cryotherapy for anogenital warts
Emotional distress
Variable retinoid results

This study discussed the use of retinoids (isotretinoin) as adjuvant therapy for anogenital warts, considering the effectiveness of cryotherapy as a first-line treatment and the variable results reported for retinoids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

55.

Intralesional Antigen Immunotherapy in the Treatment of Periungual Warts.

Author: NofalAhmad, AlakadRania, FoudaIbrahim, FawzyMohamed M

Wart clearance
Transient adverse effects

Intralesional antigen immunotherapy with measles, mumps, rubella (MMR) vaccine, Candida antigen, and purified protein derivative (PPD) was effective for treating periungual warts in 70-80% of patients. Adverse effects were transient and insignificant.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

The place of 5-aminolaevulinic acid-photodynamic therapy in the treatment landscape of urethral warts: A systematic review.

Author: KechichianElio, HelouElie, SarkisJulien, HayekClaude, LabakiChris, NemrElie, TombRoland

Urethral wart clearance
Adverse events

This systematic review of 26 articles found that 5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) was the most effective treatment for urethral condylomas in terms of clearance and recurrence rate, with a higher risk of adverse events compared to laser therapy or topical treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Intralesional Candida antigen versus intralesional vitamin D3 in the treatment of recalcitrant multiple common warts.

Author: Abdel RazikLamis Hosny, ObaidZakaria Mahran, FoudaIbrahim

Candida antigen for warts

Intralesional Candida antigen injection was more effective than vitamin D3 for treating multiple recalcitrant common warts, with a 76.7% clearance rate and minimal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

58.

Comparative study between intralesional injection of MMR, BCG, and candida albicans antigen in treatment of multiple recalcitrant warts.

Author: EldahshanRamadan Mohamed, AshryWalaa Mohamed Omar, ElsaieMohamed L

Wart clearance
Side effects

Intralesional injections of MMR, BCG, and candida antigens were effective in treating cutaneous warts in a randomized clinical trial of 90 patients. Complete wart clearance was observed in 73.33% of patients receiving MMR, 70% receiving BCG, and 43.33% receiving candida antigen. While side effects were rare and mild, further studies are needed to determine the ideal immunotherapeutic agent and dosage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

60.

Oral isotretinoin versus acitretin in male patients with multiple recalcitrant common warts: A randomized, double-blinded placebo-control study.

Author: NofalAhmad, FawzyMohamed M, EldeebFatma, ElhawaryEsraa Elsayed

Minimal side effects
Wart treatment
Mild side effects

Oral isotretinoin and acitretin are effective treatments for multiple recalcitrant common warts, with acitretin showing slightly greater efficacy. A randomized controlled trial found that both treatments were significantly more effective than placebo, with complete clearance rates of 60% for isotretinoin and 73.3% for acitretin. Adverse effects were mild and transient.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

61.

Intralesional Measles, Mumps, Rubella Vaccine versus Tuberculin Purified Protein Derivative Injections in the Treatment of Palmoplantar and Periungual Warts: A Double-Blind Randomized Controlled Trial.

Author: RutninSuthinee, NamasondhiAmornrut, PomsoongCherrin, KositkuljornChaninan, AnuntrangseeTanaporn, ThadaniponKunlawat

Distant warts
High efficacy

Intralesional immunotherapy with measles, mumps, rubella vaccine (MMR) and tuberculin purified protein derivative (PPD) can be effective for palmoplantar and periungual warts. Further research is needed to compare the effects of these treatments and the role of dermoscopy in predicting treatment outcomes.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

62.

Effect of 5-Aminolevulinic Acid Photodynamic Therapy with Transfer Factor Capsules in the Treatment of Multiple Plantar Warts.

Author: WuChen, QiuXiamin, HeCaifeng, CiChao

Plantar wart treatment
Recurrence reduction

Photodynamic therapy combined with immunomodulators significantly increased the cure rate (86.96%) and reduced the recurrence rate (20%) of multiple plantar warts compared with traditional cryotherapy combined with immunomodulators.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

63.

Emerging Intralesional Treatments for Plantar Warts: A Systematic Review.

Author: MartinAmylee, ThatiparthiAkshitha, NourmohammadiNiki, NguyenCristina, SungCalvin, Atanaskova MesinkovskaNatasha

Plantar wart treatment

This review investigated the effectiveness of various intralesional treatments for plantar warts over the past decade. The research found that while multiple treatment options have emerged, there is still no clear consensus on the most effective approach. This suggests that more research is needed to determine the optimal treatment strategy for plantar warts.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

65.

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts.

Author: HalimHalim Maher, AhmedSahar Fathy Abd Elshafy, EyadaMoustafa Mk

Genital wart treatment

Diphenylcyclopropenone is more effective than podophyllin in treating genital warts with a higher success rate and lower recurrence rate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

66.

Nowarta110 Topical <i>Versus</i> Placebo for the Treatment of Plantar Warts: A Phase I/II Randomized Controlled Clinical Trial.

Author: YousefpourMahkameh, ZamanianIraj, AkbarpourFerre, FangWilliam H, HanB O, HoangBa X

Plantar wart treatment

This research compares the efficacy and safety of a naturally derived topical formula (Nowarta110) with a placebo for treating plantar warts. Plantar warts are common and can be painful and uncomfortable.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

67.

Evaluation of combined treatment with Er:YAG laser and long-pulsed Nd:YAG laser for the treatment of recalcitrant warts: A prospective randomized controlled trial.

Author: JiryisB, Avitan-HershE, MirmovichO, Judith NevetM, KhamaysiZ

Effective treatment
Increased clearance rate

A combination of Er:YAG and long-pulsed Nd:YAG lasers was more effective than Er:YAG laser alone in treating recalcitrant warts after a single session.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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