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The Novel Atypical Dopamine Uptake Inhibitor <i>(S)</i>-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding.

Author: CariaFrancesca, CorreaMerce, De LucaMaria Antonietta, DragacevicVladimir, KalabaPredrag, LangerThierry, LubecGert, PistisMarco, PresbyRose E, RollerAlexander, RotoloRenee A, SalamoneJohn D, SamelsShanna, SchwartzRebecca, UrbanErnst, WackerligJudith, YangJen-Hau, ZehlMartin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes the enantioselective synthesis and initial chemical characterization of <i>(<b>S</b>)</i>-CE-123, a novel atypical DA transport blocker. <i>(<b>S</b>)</i>-CE-123 partially reversed the effort-related effects of tetrabenazine, a vesicular monoamine transport blocker, in rats. <i>(<b>S</b>)</i>-CE-123 also increased lever pressing on a progressive ratio/chow feeding choice task and increased extracellular DA in the nucleus accumbens core. These findings suggest that <i>(<b>S</b>)</i>-CE-123 may be a useful treatment for effort-related motivational dysfunction in humans.
Paper Details　
Original Abstract of the Article :
Animal studies of effort-based choice behavior are being used to model effort-related motivational dysfunctions in humans. With these procedures, animals are offered a choice between high-effort instrumental actions leading to highly valued reinforcers vs. low effort/low reward options. Several prev...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611521/

データ提供：米国国立医学図書館（NLM）

A Novel Approach to Boosting Motivation: (S)-CE-123

In the desert of human motivation, we often encounter challenging sand dunes of effort and reward. This study explores the potential of a novel atypical dopamine uptake inhibitor, (S)-CE-123, to address effort-related motivational dysfunctions. Like a skilled camel navigating the shifting sands, (S)-CE-123 partially reverses the effects of tetrabenazine, a dopamine-depleting agent, and increases progressive ratio responding in rats. This research suggests that (S)-CE-123 could be a promising treatment for effort-related motivational dysfunction in humans, potentially helping individuals overcome the obstacles that stand in the way of their goals.

(S)-CE-123: A Potential Solution to Motivational Challenges

The study found that (S)-CE-123 partially reversed the effort-related effects of tetrabenazine, a dopamine-depleting agent. This suggests that (S)-CE-123 could potentially help individuals overcome the challenges of low motivation and increase their willingness to put in effort. The ability of (S)-CE-123 to enhance progressive ratio responding is another significant finding. This suggests that (S)-CE-123 could help individuals persist in their efforts even when faced with increasing challenges, ultimately leading to greater success.

(S)-CE-123: A Potential Beacon in the Desert of Motivation

This research is like finding a hidden oasis in the desert of motivation. (S)-CE-123 holds the potential to help individuals overcome their motivational struggles, enabling them to reach their full potential. While further research is necessary, this study offers a promising glimpse into the future of treating effort-related motivational dysfunction.

Dr.Camel's Conclusion

This study highlights the potential of (S)-CE-123 to improve motivation and effort-related behaviors. As we continue to explore the vast desert of the brain, we may discover more effective ways to address motivational challenges and unlock the full potential of human cognition.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

31316379

DOI: Digital Object Identifier

PMC6611521

SNS
PICO Info
in preparation
Languages

English

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