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Subcutaneous brompheniramine for cutaneous analgesia in rats.
Author: ChenJen-Yin, ChenYu-Wen, ChiuChong-Chi, HungChing-Hsia, WangJhi-Joung
Original Abstract of the Article :
Brompheniramine as an antihistamine blocked sodium channels, and local anesthetics by blocking sodium channels produced the local anesthetic effects. The authors aimed to assess local anesthetic quality and duration of brompheniramine when compared to the local anesthetic mepivacaine. After rats wer...See full text at original site
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引用元:
https://doi.org/10.1016/j.ejphar.2019.172544
データ提供:米国国立医学図書館(NLM)
Brompheniramine: A New Hope for Cutaneous Analgesia
The pursuit of effective and safe [cutaneous analgesia] is an ongoing challenge in the field of [pain management]. This study explores the potential of [brompheniramine], a common [antihistamine], as a novel local anesthetic. Researchers compared the analgesic effects of brompheniramine with [mepivacaine], a standard local anesthetic. Their preclinical experiments in rats revealed that brompheniramine induced a dose-dependent analgesic effect and provided a longer duration of action than mepivacaine. It's like discovering a new and effective oasis in the desert, offering a solution to a common problem.
Brompheniramine: A Promising Alternative for Cutaneous Analgesia
The findings of this study suggest that brompheniramine could be a valuable alternative to traditional local anesthetics for treating cutaneous pain. Its prolonged duration of action and improved efficacy compared to mepivacaine could make it a more desirable option for certain types of pain. It's like having a camel that can travel farther and faster, reaching the desired destination more efficiently.
Further Research Needed to Confirm Clinical Applicability
While these preclinical results are encouraging, more research is needed to confirm the safety and efficacy of brompheniramine as a local anesthetic in humans. Further studies are necessary to optimize dosage regimens and to assess potential side effects. As a wise camel, I always say, it's important to test the waters before taking a full plunge into a new territory.
Dr.Camel's Conclusion
This preclinical study suggests that brompheniramine may hold promise as a novel local anesthetic for cutaneous analgesia. Further research is warranted to confirm its safety and efficacy in humans.
Date :
- Date Completed 2020-01-08
- Date Revised 2020-01-08
Further Info :
Related Literature
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