Association between zidovudine-containing antiretroviral therapy exposure in utero and leukocyte telomere length at birth.

Author: , Beilstein-WedelErin, BrummelSean S, ChadwickEllen G, ChanockStephen J, DagnallCasey L, EngelsEric A, HazraRohan, KacanekDeborah, MachielaMitchell J, MarsitCarmen J, PoirierMiriam C, SavageSharon A, WangYoujin

Paper Details 
Original Abstract of the Article :
OBJECTIVES: Zidovudine (ZDV) is a nucleoside reverse transcriptase inhibitor that could cause telomere shortening through inhibition of telomerase. We examined the association between in utero exposure to ZDV and telomere length at birth in HIV-exposed-uninfected (HEU) newborns. METHODS: We selecte...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/31335808

データ提供:米国国立医学図書館(NLM)

Zidovudine and Telomere Length: A Closer Look

Zidovudine (ZDV), a common antiretroviral therapy, has been a game-changer for people living with HIV. However, there are some concerns about its long-term effects. This research investigates the association between in utero exposure to ZDV and telomere length at birth. Telomeres are protective caps at the ends of chromosomes, and their shortening can contribute to aging and disease. The researchers found that ZDV-exposed infants had longer telomere lengths compared to unexposed infants, suggesting that ZDV may have unexpected benefits in this context.

Zidovudine and Telomere Length: A Twist in the Tale

This research is like discovering a hidden oasis in the midst of a desert, offering a surprising and welcome respite. The study found that ZDV-exposed infants had longer telomere lengths compared to unexposed infants, which challenges previous assumptions about the effects of ZDV on telomeres. This finding suggests that ZDV, while potentially beneficial for people living with HIV, may also have unexpected positive effects in other contexts.

Understanding Zidovudine: A Journey of Discovery

This study highlights the complexity of understanding the effects of medications, even those that have been used for many years. It is like exploring a vast and intricate desert, where each step reveals new and unexpected insights. We need to continue to investigate the long-term effects of ZDV, both beneficial and potentially harmful, to ensure that it is used safely and effectively. This research is a reminder that our understanding of medicine is constantly evolving, and we must remain open to new discoveries.

Dr. Camel's Conclusion

This study presents an intriguing finding: ZDV, an antiretroviral medication, may have unexpected benefits in terms of telomere length. This research is a testament to the ongoing quest to understand the complex interactions between medications and the human body. It reminds us that there is always more to learn, and we must remain open to new discoveries as we continue to explore the vast and fascinating landscape of medicine.

Date :
  1. Date Completed 2020-09-30
  2. Date Revised 2021-01-10
Further Info :

Pubmed ID

31335808

DOI: Digital Object Identifier

NIHMS1536833

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Languages

English

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