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Effect of the novel histamine H<sub>4</sub> receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss.
Author: Delgado BetancourtViviana, Dyhrfjeld-JohnsenJonas, GueguenCindy, PetremannMathieu, WersingerEric
Original Abstract of the Article :
Label="BACKGROUND AND PURPOSE">Histamine H<sub>4</sub> receptors are expressed in the peripheral vestibular system, and their selective inhibition improves vertigo symptoms in rats with unilateral vestibular lesions. The effects of SENS-111, a selective oral H<sub>4</sub> receptor antagonist with hi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012942/
データ提供:米国国立医学図書館(NLM)
The Quest for Vertigo Relief: SENS-111 Takes Center Stage
Vertigo, a sensation of dizziness and spinning, can be a disorienting and debilitating experience. This study explores the potential of a novel histamine H4 receptor antagonist, SENS-111, for treating vertigo. The researchers investigated the effects of SENS-111 on spontaneous nystagmus, a characteristic eye movement associated with vertigo, in a rat model of acute unilateral vestibular loss, a common cause of vertigo.
A New Oasis in the Desert of Vertigo: SENS-111 Shows Promise
The results of the study suggest that SENS-111 may be a promising therapeutic agent for treating vertigo. The researchers observed a significant reduction in spontaneous nystagmus in rats treated with SENS-111 compared to control animals. This finding provides evidence for the potential of histamine H4 receptor antagonism as a target for the development of effective vertigo treatments.
A Glimpse into the Future: Hope for Vertigo Sufferers
This research opens a new avenue for the treatment of vertigo, potentially offering a novel and effective therapeutic option. While further studies are needed to confirm the effectiveness of SENS-111 in humans, the findings from this animal model provide a glimmer of hope for individuals struggling with this debilitating condition. The development of new and effective vertigo treatments could significantly improve the quality of life for many individuals.
Dr.Camel's Conclusion
Vertigo can be a dizzying experience, like being lost in a swirling sandstorm. This research highlights the potential of SENS-111 to provide relief, offering a glimpse of a future where vertigo can be effectively treated. As we continue to explore this promising avenue, we may find a new oasis in the desert of vertigo, bringing hope and well-being to those affected by this condition.
Date :
- Date Completed 2021-06-21
- Date Revised 2021-06-21
Further Info :
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