The role of mifepristone in the management of meningiomas: A systematic review of literature.

Author: AgarwalDeepak, ChandraSarat P, GargKanwaljeet, KaleShashank S, KatiyarVaridh, MahapatraAshok K, SharmaRavi, SinghManmohan, SuriAshish, TandonVivek

Paper Details 
Original Abstract of the Article :
BACKGROUND: Surgery is challenging in patients with multiple or recurrent meningiomas. With the discovery of progesterone receptors (PR) on meningioma cells, there is an increased interest in the hormonal treatment using mifepristone, a PR blocker. MATERIALS AND METHODS: A systematic review of clin...See full text at original site
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引用元:
https://doi.org/10.4103/0028-3886.263232

データ提供:米国国立医学図書館(NLM)

Mifepristone's Role in Meningioma Management

Meningiomas, benign tumors that develop in the brain, can be challenging to treat, especially when they are multiple or recurrent. This study explores the potential of mifepristone, a progesterone receptor blocker, as a hormonal treatment for meningiomas. The researchers conducted a systematic review of clinical studies, evaluating the efficacy and side effects of mifepristone in managing these tumors. Their findings suggest that while mifepristone may offer some benefit, particularly for patients with diffuse meningiomatosis, further research is needed to understand its mechanisms of action and identify responsive patient subsets.

The Promise of Hormonal Therapy

This research sheds light on the potential of hormonal therapy in treating meningiomas. The study's findings, while promising, highlight the need for further research to optimize the use of mifepristone. Further investigation into the mechanisms of action and the identification of responsive patient subsets will be crucial for realizing the full potential of this approach.

Navigating the Labyrinth of Meningioma Treatment

The researchers likened the search for effective meningioma treatment to navigating a labyrinth. Just as a traveler must carefully choose their path to avoid getting lost, clinicians must carefully consider the various treatment options and select the most appropriate approach for each patient. This study provides valuable insights into the potential role of hormonal therapy, but it also highlights the need for further research to clarify its efficacy and optimize its use.

Dr.Camel's Conclusion

This systematic review offers valuable insights into the potential of mifepristone as a hormonal treatment for meningiomas. While promising, the study underscores the need for further research to understand the mechanisms of action, identify responsive patient subsets, and refine treatment strategies. This research highlights the ongoing quest for effective and safe treatments for challenging conditions such as meningiomas, emphasizing the importance of continuous exploration and refinement of treatment options.

Date :
  1. Date Completed 2020-02-06
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

31347538

DOI: Digital Object Identifier

10.4103/0028-3886.263232

Related Literature

SNS
PICO Info
in preparation
Languages

English

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