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5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.

Author: CastellaniRudy J, DeyPrasanta Kumar, MuresanuDafin Fior, SharmaAruna, SharmaHari Shanker, SmithMark A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

5-Hydroxytryptophan (5-HTP) can cause neurotoxicity by affecting the blood-brain barrier, edema formation, and regional cerebral blood flow.
Paper Details　
Original Abstract of the Article :
5-Hydroxytryptophan (5-HTP), a precursor of serotonin, is therapeutically used for several psychiatric disorders such as anxiety and depression in the clinic. However, severe side effects, including abnormal mental functions, behavioral disturbances and intolerance are associated with this treatment...See full text at original site
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引用元：
https://doi.org/10.1016/bs.irn.2019.06.005

データ提供：米国国立医学図書館（NLM）

5-Hydroxytryptophan: A Complex Journey Through the Brain

5-Hydroxytryptophan (5-HTP), a precursor of the neurotransmitter serotonin, is used to treat certain psychiatric conditions. This study investigates the potential neurotoxic effects of 5-HTP, focusing on its impact on the blood-brain barrier (BBB), cerebral blood flow, brain edema formation, and neuronal injury in rats.

Navigating the Brain's Labyrinth: Understanding 5-HTP's Effects

The study reveals that 5-HTP administration led to elevated serotonin levels in both the plasma and brain, accompanied by a breakdown of the BBB, reduced cerebral blood flow, and brain edema formation. These findings suggest that 5-HTP's neurotoxicity could be mediated through its effects on the BBB and cerebral blood flow.

A Complex Landscape: Balancing Benefits and Risks

This study highlights the complex nature of 5-HTP's effects on the brain. While it is a promising therapeutic agent for certain conditions, its potential neurotoxicity warrants careful consideration. Further research is needed to fully understand the mechanisms underlying 5-HTP's effects and to develop safer and more effective treatment strategies.

Dr.Camel's Conclusion

The study delves into the complex and sometimes paradoxical effects of 5-HTP on the brain, highlighting its potential benefits and risks. By understanding the mechanisms underlying 5-HTP's actions, researchers can develop safer and more targeted therapies for psychiatric conditions while minimizing potential adverse effects.

Date :
  1. Date Completed 2020-02-03
  2. Date Revised 2020-02-03
Further Info :

Pubmed ID

31349924

DOI: Digital Object Identifier

10.1016/bs.irn.2019.06.005

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