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Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.
Author: AlexiadesNikita G, BanuMatei, BruceJeffrey N, CanollPeter, D'AmicoRandy S, EnglanderZachary K, GuoXiaotao, KennedyBenjamin C, NeiraJustin A, RomanovAlexander, RothrockRobert J, SonabendAdam M, UngTimothy H, YunJonathan, ZhaoBinsheng
Original Abstract of the Article :
Intracerebral convection-enhanced delivery (CED) has been limited to short durations due to a reliance on externalized catheters. Preclinical studies investigating topotecan (TPT) CED for glioma have suggested that prolonged infusion improves survival. Internalized pump-catheter systems may facilita...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31374547
データ提供：米国国立医学図書館（NLM）
Chronic Convection-Enhanced Delivery: A New Frontier in Glioma Treatment
The [treatment of glioma] continues to pose significant challenges, with [prolonged drug delivery] being a key aspect of effective therapy. This study investigates the safety and efficacy of a new implantable pump-infusion system for delivering topotecan, a chemotherapy drug, via convection-enhanced delivery (CED) in a large animal model. It's like exploring a new oasis in the desert of glioma research, seeking innovative ways to deliver drugs directly to the tumor site. The researchers examined the feasibility and potential benefits of this novel approach for long-term drug delivery.
Chronic CED: A Potential Game-Changer in Glioma Treatment
This study demonstrates the feasibility and safety of using an implantable pump-infusion system for chronic CED of topotecan in a large animal model. This is a significant advancement, like finding a sustainable water source in the desert, offering a potential path to more effective and prolonged glioma treatment. The findings suggest that this innovative approach could significantly improve the delivery of chemotherapy drugs to the tumor site, potentially leading to better outcomes for patients.
The Future of Glioma Treatment: A Journey of Innovation
This study highlights the potential of chronic CED as a promising avenue for glioma treatment. It's like discovering a new desert trail, offering a more efficient and effective way to deliver treatment directly to the tumor. The findings underscore the importance of ongoing research and development in this area, paving the way for more innovative and effective therapies for glioma patients.
Dr. Camel's Conclusion
This study offers a glimpse into the future of glioma treatment, demonstrating the potential of chronic CED to improve drug delivery and potentially enhance patient outcomes. It highlights the ongoing quest for innovative and effective treatments for this challenging disease, reminding us that the desert of glioma research is constantly evolving, revealing new oases of hope and progress.
Date :
- Date Completed n.d.
- Date Revised 2021-04-30
Further Info :
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