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Eluted 25-hydroxyvitamin D<sub>3</sub> from radially aligned nanofiber scaffolds enhances cathelicidin production while reducing inflammatory response in human immune system-engrafted mice.

Author: ChenShixuan, ChengYan, GeLiangpeng, GombartAdrian F, GorantlaSanthi, PoluektovaLarisa Y, WangHongjun, XieJingwei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Vitamin D<sub>3</sub> is a nutrient that can help to strengthen the immune system. Researchers are studying the possibility of using vitamin D<sub>3</sub>-releasing materials to prevent infections and improve the success of implants.
Paper Details　
Original Abstract of the Article :
Vitamin D<sub>3</sub> modulates immune response, induces endogenous antimicrobial peptide production, and enhances innate immunity to defend against infections. These findings suggest that incorporating vitamin D<sub>3</sub> into medical devices or scaffolds could positively modulate host immune res...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31386930

データ提供：米国国立医学図書館（NLM）

Vitamin D3: A New Ally in the Fight Against Infection

Vitamin D3, a crucial nutrient for bone health, is also emerging as a powerful modulator of the immune system. This research investigates the potential of incorporating vitamin D3 into medical devices or scaffolds to enhance the immune response and prevent infections. The study focuses on 25-hydroxyvitamin D3 (25(OH)D3)-eluting radially aligned PCL nanofiber scaffolds, evaluating their impact on host responses and antimicrobial peptide production in human immune system-engrafted mice. The findings highlight the potential of vitamin D3-eluting scaffolds for modulating immune responses and promoting antimicrobial peptide production, potentially improving the success rates of implants and reducing the risk of infections.

Vitamin D3: A Double-Edged Sword in the Immune System

The study demonstrates that vitamin D3-eluting scaffolds can significantly enhance the production of cathelicidin, an antimicrobial peptide, while simultaneously reducing the inflammatory response. This finding suggests that vitamin D3 can play a dual role in promoting immune function and protecting against infections. This discovery could revolutionize the design of medical devices and scaffolds, leading to improved implant success rates and reduced risk of complications.

A New Frontier in Biomaterial Design: Harnessing the Power of Vitamin D3

The study highlights the potential of vitamin D3-eluting scaffolds for promoting immune modulation and antimicrobial peptide production. This innovative approach could significantly improve the success rates of implants and reduce the risk of infections, ultimately improving patient outcomes. The research underscores the importance of exploring the potential of natural compounds in designing novel biomaterials for medical applications.

Dr.Camel's Conclusion

Vitamin D3, a crucial nutrient for bone health, shows promise for enhancing the immune system. It's like finding a hidden spring in the desert - a source of strength and protection against infection. This research opens up exciting possibilities for developing new and more effective medical devices and scaffolds.

Date :
  1. Date Completed 2020-08-13
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

31386930

DOI: Digital Object Identifier

NIHMS1536542

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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