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Treating ischemia via recruitment of antigen-specific T cells.

Author: KweeBrian J, LiAileen W, MooneyDavid J, NajibiAlexander J, SeoBo Ri, ShihTing-Yu, WhiteDes

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the potential of antigen-releasing scaffolds in promoting vascularization of ischemic tissue. By implanting these scaffolds in previously vaccinated mice, the researchers observed a concentration of antigen-specific T<sub>H</sub>2 T cells, leading to angiogenesis and improved perfusion in ischemic limbs. This approach could offer a promising therapeutic strategy for treating ischemic diseases in individuals with prior vaccination.
Paper Details　
Original Abstract of the Article :
Ischemic diseases are a leading cause of mortality and can result in autoamputation of lower limbs. We explored the hypothesis that implantation of an antigen-releasing scaffold, in animals previously vaccinated with the same antigen, can concentrate T<sub>H</sub>2 T cells and enhance vascularizatio...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669016/

データ提供：米国国立医学図書館（NLM）

Reviving Ischemic Tissues: A Novel Approach with Antigen-Specific T Cells

Ischemic diseases, a leading cause of death, often result in limb loss due to inadequate blood flow. This research explores a novel therapeutic strategy for treating ischemia by harnessing the power of antigen-specific T cells. The study demonstrated that implanting an antigen-releasing scaffold in animals previously vaccinated with the same antigen could concentrate TH2 T cells, promoting blood vessel formation in ischemic tissue. The findings suggest that this approach may be clinically relevant, especially for individuals previously vaccinated with aluminum-containing adjuvants.

Antigen-Specific T Cells: A New Weapon Against Ischemia

This study presents an innovative approach to treating ischemic diseases by harnessing the body’s own immune system. The findings suggest that antigen-specific T cells may play a crucial role in promoting blood vessel growth and improving blood flow to ischemic tissues. Further research is needed to explore the clinical potential of this approach and assess its safety and efficacy in human patients.

Harnessing the Power of the Immune System to Treat Ischemia

This study highlights the exciting potential of manipulating the immune system to treat ischemic diseases. It’s a testament to the power of the immune system and its ability to heal and repair damaged tissues. It’s like a desert ecosystem, where even a single drop of water can revive life in seemingly barren landscapes. The study opens new avenues for exploring immune-based therapies for a range of diseases.

Dr. Camel's Conclusion

Ischemic diseases are like a relentless desert drought, leaving tissues parched and struggling to survive. This study explores an intriguing approach to fighting ischemia, harnessing the power of the immune system to bring life back to damaged tissues. The findings offer a glimmer of hope for treating ischemic diseases, much like the arrival of a life-giving rain in the desert.

Date :
  1. Date Completed 2020-04-29
  2. Date Revised 2020-05-06
Further Info :

Pubmed ID

31392268

DOI: Digital Object Identifier

PMC6669016

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Languages

English

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