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Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria.
Author: ChenWangqing, ChenXiang, LiJie, LiJuan, LiuZhaoqian, PengCong, SuJuan, ZhangWei, ZhuWu
Original Abstract of the Article :
H1 nonsedating antihistamines, such as desloratadine, are first-line treatment options for chronic spontaneous urticaria (CSU). However, desloratadine induces various degrees of sedation side effect in CSU patients, and no biomarkers currently exist for predicting the severity of such side effect. H...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1038/s41397-019-0094-0
データ提供:米国国立医学図書館(NLM)
Desloratadine and Sedation: A Genetic Connection
The world of allergy research is constantly seeking to understand the individual responses to medications. This study investigates the potential association between a genetic polymorphism in the histamine H1 receptor (HRH1) gene and the severity of sedation side effects after desloratadine treatment in patients with chronic spontaneous urticaria (CSU). The researchers [study design] to evaluate the relationship between [specific genetic variation] and [specific side effect] in a group of patients with CSU. Their findings suggest that individuals with a specific genotype may be at higher risk for experiencing sedation side effects after desloratadine treatment. This research provides valuable insights for clinicians seeking to personalize treatment strategies for patients with CSU.
HRH1 Gene Polymorphism: A Potential Predictor of Side Effects
This research highlights the potential importance of genetic factors in predicting side effects from medications. The study found that [specific result], suggesting that a specific genotype may be associated with an increased risk of sedation side effects after desloratadine treatment. This study provides valuable insights for clinicians seeking to personalize treatment strategies for patients with CSU.
Personalized Medicine: Tailoring Treatment to Individual Needs
This research underscores the importance of personalized medicine in addressing health concerns. The findings suggest that [specific recommendation] can be crucial for optimizing treatment outcomes and minimizing side effects. It's a reminder that addressing allergic conditions requires a careful assessment of individual needs and preferences.
Dr.Camel's Conclusion
This research sheds light on the potential role of genetic factors in predicting side effects from medications. The study's findings highlight the importance of personalized medicine and encourage further research to develop genetic tests that can help clinicians tailor treatment strategies to the individual needs of their patients.
Date :
- Date Completed 2021-01-04
- Date Revised 2022-04-20
Further Info :
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