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Sulfonylurea derivatives and cancer, friend or foe?

Author: BiloHenk J G, HendriksAnne M, JalvingMathilde, KleefstraNanne, LandmanGijs W D, SchrijndersDennis, de VriesElisabeth G E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Type 2 diabetes mellitus (T2DM) is associated with increased cancer risk. This review explores the influence of different sulfonylurea derivatives (SUs) on cancer development and risk. Evidence suggests that the influence of SUs on cancer risk varies depending on the specific SU used.
Paper Details　
Original Abstract of the Article :
Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at least in part, responsible for this effect. Indeed, lowering glucose and/or insulin levels pharmacologically appears to redu...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1016/j.ejphar.2019.172598

データ提供：米国国立医学図書館（NLM）

Sulfonylurea Derivatives: A Complex Relationship with Cancer Risk

This research examines [the complex relationship between sulfonylurea derivatives (SUs) and cancer risk]. The study explores [the conflicting evidence regarding the influence of SUs on cancer risk] and highlights [the importance of considering within-class differences] in [the systemic and off-target effects of SUs]. The authors provide a comprehensive review of [preclinical and clinical evidence] to assess [the potential benefits and risks] of using SUs for [the treatment of type 2 diabetes mellitus (T2DM)].

Navigating the Complexities of Sulfonylurea Derivatives

The study reveals that [the impact of SUs on cancer risk] is not straightforward and may vary depending on [the specific SU, the dose, and individual factors]. The researchers suggest that [some SUs may have anti-cancer effects] while others may [increase cancer risk]. This underscores the need for [careful consideration] when prescribing SUs for T2DM patients.

Understanding the Risks and Benefits of Sulfonylureas

Like a camel navigating a desert landscape, we must be aware of the potential risks and benefits of [different treatment options]. This research provides valuable insights into [the complex relationship between sulfonylureas and cancer risk]. It emphasizes the importance of [personalized medicine] and [tailoring treatment plans] to individual patient needs.

Dr.Camel's Conclusion

This research is like a camel caravan crossing a vast and intricate desert, revealing the complex relationship between sulfonylureas and cancer risk. It highlights the need for a nuanced understanding of these medications and emphasizes the importance of personalized medicine to ensure optimal outcomes for patients.

Date :
  1. Date Completed 2020-02-06
  2. Date Revised 2020-02-06
Further Info :

Pubmed ID

31408647

DOI: Digital Object Identifier

10.1016/j.ejphar.2019.172598

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English

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