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A randomized comparison of nonoral estradiol delivery in postmenopausal women.

Author: LoboR A, Macias-GonzalesP, NunezV, ShoupeD, StanczykF Z, VijodM A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Estradiol pellets provided a more consistent delivery of estrogen than transdermal patches in 20 postmenopausal women. The pellets also showed greater suppression of follicle-stimulating hormone and more consistent reduction in the urinary calcium/creatinine ratio.
Paper Details　
Original Abstract of the Article :
We compared the transdermal and subdermal routes of estrogen administration with respect to the constancy of estrogen delivery and metabolic effects. Twenty postmenopausal women were randomized to receive either two 25 mg estradiol pellets subdermally (n = 10) or a 0.1 mg estradiol transdermal patch...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9378(88)90591-1

データ提供：米国国立医学図書館（NLM）

Comparing Estrogen Delivery Methods

This research is like exploring different oases in a desert, each offering a unique approach to replenishing the body's resources. The study compares two methods of delivering estrogen to postmenopausal women: transdermal patches and subdermal pellets. These methods are like two different pathways through the desert, each with its own characteristics and potential benefits. The authors meticulously analyze the effects of each delivery method on estrogen levels, metabolic markers, and overall well-being.

Estrogen Delivery: Finding the Right Path

The study reveals significant differences in the delivery patterns and metabolic effects of transdermal patches and subdermal pellets, like two distinct paths through a desert, each leading to different outcomes. The research shows that subdermal pellets provide a more consistent and prolonged release of estrogen, while transdermal patches offer a more fluctuating delivery pattern. The authors also highlight the impact of each delivery method on lipid profiles and urinary calcium levels. This research suggests that choosing the most suitable estrogen delivery method depends on individual needs and preferences.

Navigating Menopause

This research provides valuable insights for women navigating the transition through menopause, like a journey through a desert landscape. The authors highlight the importance of considering different estrogen delivery methods and their impact on overall health and well-being. The study underscores the need for personalized care and a collaborative approach between patients and healthcare providers.

Dr.Camel's Conclusion

This research explores the complex world of estrogen delivery methods, highlighting the importance of finding the right path through the desert of menopause. The study compares transdermal patches and subdermal pellets, revealing key differences in their delivery patterns and metabolic effects. This research serves as a valuable guide for both doctors and patients, emphasizing the need for personalized care and a careful consideration of treatment options.
Date :
  1. Date Completed 1989-01-31
  2. Date Revised 2019-06-15
Further Info :

Pubmed ID

3144919

DOI: Digital Object Identifier

10.1016/0002-9378(88)90591-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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